Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.400 AlteredExpression BEFREE TRAIL can stimulate the expression of uPA, IL-8, MMP-7 and MMP-9 in pancreatic cancer cell lines, especially in Colo357wt. 18397859

2008
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.400 Biomarker BEFREE Furthermore, we observed increased sensitivity of G1-arrested pancreatic cancer cells towards TRAIL-induced apoptosis. 17304504

2007
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.400 AlteredExpression BEFREE Thus, our findings for the first time indicate that targeting XIAP represents a promising strategy to enhance the antitumor activity of TRAIL in pancreatic cancer, which has important clinical implications. 16832350

2007
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.400 Biomarker BEFREE Our results suggest that TRAIL gene therapy in combination with gemcitabine might be a useful therapeutic approach for treating metastatic pancreatic cancers. 15486557

2005
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.400 Biomarker BEFREE Geldanamycin, PS-341, and TRAIL triple combination may be a novel therapeutic strategy for pancreatic cancer. 15781649

2005
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.400 Biomarker BEFREE These findings give new insight into the resistance mechanisms of pancreatic cancer towards TRAIL-mediated apoptosis. 11848467

2002
Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.400 Biomarker BEFREE These findings show that pancreatic cancers are insensitive towards TRAIL-mediated apoptosis despite expression of TRAIL and its receptors, suggesting the presence of mediators which inhibit the TRAIL cell-death-inducing pathway in pancreatic cancer cells. 11163110

2001