Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0010200
Disease: Coughing
Coughing 		0.400 Biomarker BEFREE The candesartan group included 5 subjects with a history of ACE inhibitor-induced cough. 11457745

2001
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0010200
Disease: Coughing
Coughing 		0.400 Biomarker BEFREE The observation that cough challenge is dependent on ACE genotype in normal subjects is evidence of a link between ACE activity and the cough reflex. 9059468

1997
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0010200
Disease: Coughing
Coughing 		0.400 Biomarker BEFREE Pharmacogenetic predictors of angiotensin-converting enzyme inhibitor-induced cough: the role of ACE, ABO, and BDKRB2 genes. 21832968

2011
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0010200
Disease: Coughing
Coughing 		0.400 Biomarker BEFREE Cough and ACE Inhibitors: The Truth Beyond Placebo. 29468656

2019
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0010200
Disease: Coughing
Coughing 		0.400 Biomarker BEFREE However, ACE inhibitors remain associated with cough and a very low risk of angioedema and fatalities. 29598869

2018
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0010200
Disease: Coughing
Coughing 		0.400 Biomarker BEFREE Angiotensin-converting enzyme inhibitor-induced cough is potentially associated with genes that are independent of bradykinin pathways. 28084903

2017
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0010200
Disease: Coughing
Coughing 		0.400 Biomarker BEFREE ABO genetic polymorphisms have recently been associated with angiotensin-converting enzyme (ACE) activity and inflammation, which play a critical role in the pathogenic mechanism of ACE inhibitor-induced cough. 24743543

2014
Entrez Id: 1636
Gene Symbol: ACE
ACE
CUI: C0010200
Disease: Coughing
Coughing 		0.400 Biomarker BEFREE A genome-wide association study identifies variants in KCNIP4 associated with ACE inhibitor-induced cough. 26169577

2016