Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 GeneticVariation BEFREE The contribution of the IL-18 promoter polymorphisms at positions -607 (C/A) and -137 (G/C) to cancer development has been reported. 19263242

2009
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 AlteredExpression BEFREE Increased serum levels of both IL-18 and transferrin in cancer patients are correlated with its malignancy. 19535202

2009
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 AlteredExpression BEFREE These data indicated that oncolytic adenovirus expressing IL-18 could exert potential antitumor activity via inhibition of angiogenesis and offer a novel approach to cancer therapy. 19305163

2009
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 GeneticVariation BEFREE Interleukin-18 [IL-18] gene promoter polymorphism is reported to be a genetic risk factor for several types of cancer. 19152241

2009
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker BEFREE These results indicate that a vaccination therapy using DC co-transduced with the TAA gene and IL-18 genes is effective strategy for immunotherapy in terms of the activation of DCs, CD4+ T, cells and CD8+ T cells, and may be useful in the clinical application of a cancer vaccine therapy. 17462500

2007
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker BEFREE The effects of gpIL-12 and gpIL-18 on the tumors implanted in guinea pigs will encourage us to use IL-12- and IL-18-inducible adjuvants for immunotherapy in human patients with solid cancer. 17888032

2007
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 AlteredExpression BEFREE Next, we studied mRNA expressions of IL-18 receptor (IL-18R) and IFN-gamma in PBMCs in cancer patients and healthy volunteers by RT-PCR assay. 11848485

2002
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker BEFREE In view of the proposed use of IL-18 in cancer immuno/gene therapy, we have studied the expression of IL-18 in tumor cells. 11948465

2002
Entrez Id: 3606
Gene Symbol: IL18
IL18
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 Biomarker BEFREE Local concentrations of these two players may determine biological functions of IL-18 in the context of inflammation, infection, and cancer. 11739524

2001