Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2571
Gene Symbol: GAD1
GAD1
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.110 GeneticVariation BEFREE A novel amino acid mis-sense mutation in GAD67 was detected, which segregated with CP in affected individuals. 15571623

2004

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.110 CausalMutation CLINVAR [Intraoperative echocardiographic assessment of left ventricular muscle volume changes after intracardiac operation under cardiopulmonary bypass]. 2614104

1989

Entrez Id: 5160
Gene Symbol: PDHA1
PDHA1
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.110 GeneticVariation CLINVAR

Entrez Id: 120
Gene Symbol: ADD3
ADD3
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.110 CausalMutation CLINVAR

Entrez Id: 6697
Gene Symbol: SPR
SPR
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.110 Biomarker HPO

Entrez Id: 2571
Gene Symbol: GAD1
GAD1
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.110 Biomarker HPO

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.100 Biomarker BEFREE DAS treatment before CP significantly decreased serum urea, creatinine, sodium, potassium, calcium, blood urea nitrogen (BUN), C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-1β (IL-1ß) and tumor necrosis factor-alpha (TNF-α) compared with CP-treated rats. 31779506

2020

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.100 Biomarker BEFREE DAS treatment before CP significantly decreased serum urea, creatinine, sodium, potassium, calcium, blood urea nitrogen (BUN), C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-1β (IL-1ß) and tumor necrosis factor-alpha (TNF-α) compared with CP-treated rats. 31779506

2020

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.100 AlteredExpression BEFREE Periodontal treatment performed in individuals with CP and gingivitis reduces the levels of TNF-α, IL-1β, IL-6 and IL-8. 31269113

2019

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.100 AlteredExpression BEFREE In addition, in CP-treated rats, PGE treatment induced the recovery of white blood cell, neutrophil, and lymphocyte counts, along with mid-range absolute counts, and increased the serum levels of inflammatory cytokines (TNF-α, IFN-γ, IL-2, and IL-12) and immunoglobulins (IgG and IgA). 31752816

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.100 GeneticVariation BEFREE Fever and increased maternal interleukin-6 (IL-6) plasma levels in labor are associated with an increased risk of adverse events in offspring, including neonatal seizures, cerebral palsy, and low intelligence scores at school age. 31094787

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.100 Biomarker BEFREE <i>Results.</i> Between healthy controls and CP patients (moderate and severe disease), a statistically significant difference was observed in the concentrations of IL-6 and IL-17. 29670909

2018

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.100 Biomarker BEFREE Our results showed that incubation with CP significantly increases the percent of cell death, activities of caspase-3 and -9, level of TNF-α and also promotes the levels of biomarkers which play important role in oxidative stress. 30127816

2018

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.100 GeneticVariation BEFREE Also, a significant increase in the risk of CP was observed to be associated with the interactions of TNF-α rs1799724 and MTHFR rs9651118 (OR 2.75, 95 % CI 1.23-6.13). 26646537

2016

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.100 Biomarker BEFREE The purpose of this study was to analyze IL-6 gene polymorphisms and protein expression and to explore the role of IL-6 in the Chinese CP population. 24903966

2014

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.100 GeneticVariation BEFREE To explore the genetic association between the polymorphisms of the IL6 gene and CP in the Chinese population. 23415255

2013

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.100 GeneticVariation BEFREE A risk haplotype at the IL6 gene likely confers risk to CP, and perhaps other diseases, via a multi-factorial mechanism. 24314052

2013

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.100 GeneticVariation BEFREE Statistically significant association was also found in patients with cPVL between TNFα TC, CC, GG, GG -1031/-857/-308/-238 genotypes combination (OR, 4.107; p=0.024), as well as IL1β TT, CC -511/+3954 genotypes combination (OR, 7.333; p=0.005) and risk of CP. 22266275

2012

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.100 GeneticVariation BEFREE The aim of our study was to evaluate the possible association of four TNFα promoter single nucleotide polymorphisms (SNPs) (-1031 T/C, -857 C/T, -308 G/A and -238 G/A), two IL1β SNPs (-511 C/T and +3954 C/T) and one IL6 (-174 C/G) polymorphism with susceptibility to CP in very preterm infants. 22266275

2012

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.100 GeneticVariation BEFREE We found a significant association between CP and IL-6 (rs1800795) [C vs G: odds ratio (OR) 1.79, 95% confidence interval (CI) 1.44-2.22, p<0.001; CC+GC vs GG: OR 1.72, 95% CI 1.29-2.29, p=0.002; CC vs GG+GC: OR 2.17, 95% CI 1.52-3.09, p<0.001], but no other genetic polymorphisms. 21291465

2011

Entrez Id: 4204
Gene Symbol: MECP2
MECP2
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.100 GeneticVariation CLINVAR Identification and characterization of novel sequence variations in MECP2 gene in Rett syndrome patients. 20031356

2010

Entrez Id: 4204
Gene Symbol: MECP2
MECP2
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.100 GeneticVariation CLINVAR Genotype-phenotype correlation in Brazillian Rett syndrome patients. 19722030

2009

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.100 GeneticVariation BEFREE Polymorphisms in IL-6 or IL-4 may act as susceptibility genes, in the presence of viral exposure, for the development of hemiplegic and quadriplegic CP. 19566553

2009

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.100 GeneticVariation BEFREE We studied whether the IL-6 -174 G/C polymorphism confers increased risk for CP in term infants. 19938160

2009

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0007789
Disease: Cerebral Palsy
Cerebral Palsy
0.100 Biomarker BEFREE There is evidence that the amount of EPO in CP children is lower than in normal children, but the levels of proinflammatory cytokines, such as interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha, are higher in the CP children. 18715729

2009