Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7298
Gene Symbol: TYMS
TYMS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.600 Biomarker CTD_human Thymidylate synthase and microsatellite instability in colorectal cancer: implications for disease free survival, treatment response and survival with metastases. 17943475

2008

Entrez Id: 7298
Gene Symbol: TYMS
TYMS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.600 Biomarker CTD_human Thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis. 19020767

2008

Entrez Id: 1806
Gene Symbol: DPYD
DPYD
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.600 Biomarker CTD_human Thymidylate synthase, dihydropyrimidine dehydrogenase, orotate phosphoribosyltransferase mRNA and protein expression levels in solid tumors in large scale population analysis. 19020767

2008

Entrez Id: 1806
Gene Symbol: DPYD
DPYD
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.600 Biomarker CTD_human DPD is a molecular determinant of capecitabine efficacy in colorectal cancer. 17611699

2007

Entrez Id: 7298
Gene Symbol: TYMS
TYMS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.600 Biomarker CTD_human Lymph node status and TS gene expression are prognostic markers in stage II/III rectal cancer after neoadjuvant fluorouracil-based chemoradiotherapy. 16943523

2006

Entrez Id: 1806
Gene Symbol: DPYD
DPYD
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.600 Biomarker CTD_human Thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer and normal mucosa in patients. 17047489

2006

Entrez Id: 7298
Gene Symbol: TYMS
TYMS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.600 Biomarker CTD_human Thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase expression in colorectal cancer and normal mucosa in patients. 17047489

2006

Entrez Id: 7298
Gene Symbol: TYMS
TYMS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.600 Biomarker CTD_human Influence of thymidylate synthase gene polymorphisms on the survival of colorectal cancer patients receiving adjuvant 5-fluorouracil. 16141798

2005

Entrez Id: 1806
Gene Symbol: DPYD
DPYD
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.600 Biomarker CTD_human Variance in the expression of 5-Fluorouracil pathway genes in colorectal cancer. 15814641

2005

Entrez Id: 1806
Gene Symbol: DPYD
DPYD
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.600 Biomarker CTD_human [Thymidylate synthase and dihydropyrimidine dehydrogenase gene expressions in colorectal cancer using the Danenberg tumor profile method]. 15222106

2004

Entrez Id: 7298
Gene Symbol: TYMS
TYMS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.600 Biomarker CTD_human [Relationship between expression of thymidylate synthase and colorectal carcinoma]. 15500737

2004

Entrez Id: 7298
Gene Symbol: TYMS
TYMS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.600 Biomarker CTD_human [Thymidylate synthase and dihydropyrimidine dehydrogenase gene expressions in colorectal cancer using the Danenberg tumor profile method]. 15222106

2004

Entrez Id: 7298
Gene Symbol: TYMS
TYMS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.600 Biomarker CTD_human Single nucleotide polymorphism in the 5' tandem repeat sequences of thymidylate synthase gene predicts for response to fluorouracil-based chemotherapy in advanced colorectal cancer patients. 15386371

2004

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 Biomarker CTD_human Paradoxical activation of MEK/ERK signaling induced by B-Raf inhibition enhances DR5 expression and DR5 activation-induced apoptosis in Ras-mutant cancer cells. 27222248

2016

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 Biomarker CTD_human Microsatellite instability: an update. 25701956

2015

Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 Biomarker CTD_human Highly Expressed Genes in Rapidly Proliferating Tumor Cells as New Targets for Colorectal Cancer Treatment. 25944804

2015

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 Biomarker CTD_human Resveratrol prevents tumorigenesis in mouse model of Kras activated sporadic colorectal cancer by suppressing oncogenic Kras expression. 25280562

2014

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 Biomarker CTD_human Resveratrol prevents tumorigenesis in mouse model of Kras activated sporadic colorectal cancer by suppressing oncogenic Kras expression. 25280562

2014

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 Biomarker CTD_human Disseminated colorectal tumor cells in organs prone to metastasis detected by new double enriched nested-PCR in comparison with recognized assays. 21369707

2011

Entrez Id: 4089
Gene Symbol: SMAD4
SMAD4
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 Biomarker CTD_human SMAD4--molecular gladiator of the TGF-beta signaling is trampled upon by mutational insufficiency in colorectal carcinoma of Kashmiri population: an analysis with relation to KRAS proto-oncogene. 20565773

2010

Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 Biomarker CTD_human SMAD4--molecular gladiator of the TGF-beta signaling is trampled upon by mutational insufficiency in colorectal carcinoma of Kashmiri population: an analysis with relation to KRAS proto-oncogene. 20565773

2010

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 Biomarker CTD_human Panitumumab: in metastatic colorectal cancer with wild-type KRAS. 18998757

2008

Entrez Id: 673
Gene Symbol: BRAF
BRAF
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 Biomarker CTD_human Impact of BRAF, MLH1 on the incidence of microsatellite instability high colorectal cancer in populations based study. 18718023

2008

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 Biomarker CTD_human Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. 19011631

2008

Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.500 Biomarker CTD_human Epidermal growth factor receptor R497K polymorphism is a favorable prognostic factor for patients with colorectal carcinoma. 17575224

2007