Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2551
Gene Symbol: GABPA
GABPA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE CDK20 interacts with KEAP1 to activate NRF2 and promotes radiochemoresistance in lung cancer cells. 28534518

2017
Entrez Id: 2551
Gene Symbol: GABPA
GABPA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE <i>KEAP1</i> silencing by promoter methylation is widely reported in solid tumors as part of the complex regulation of the KEAP1/NRF2 axis, but its prognostic role remains to be addressed in lung cancer. 31159323

2019
Entrez Id: 2551
Gene Symbol: GABPA
GABPA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE In addition, FAM129B reduces chemosensitivity by augmenting Nrf2 antioxidative signaling and confers poor prognosis in breast and lung cancer. 31262713

2019
Entrez Id: 2551
Gene Symbol: GABPA
GABPA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE Proteasome Inhibitor-Induced IκB/NF-κB Activation is Mediated by Nrf2-Dependent Light Chain 3B Induction in Lung Cancer Cells. 30396235

2018
Entrez Id: 2551
Gene Symbol: GABPA
GABPA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE Nestin regulates cellular redox homeostasis in lung cancer through the Keap1-Nrf2 feedback loop. 31695040

2019
Entrez Id: 2551
Gene Symbol: GABPA
GABPA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE miR‑144‑3p regulates the resistance of lung cancer to cisplatin by targeting Nrf2. 30542710

2018
Entrez Id: 2551
Gene Symbol: GABPA
GABPA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE Here we summarize the recent advances in NRF2-addicted lung cancer. 31574294

2019
Entrez Id: 2551
Gene Symbol: GABPA
GABPA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer. 28504720

2017
Entrez Id: 2551
Gene Symbol: GABPA
GABPA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE The effects of NRF2 modulation on the initiation and progression of chemically and genetically induced lung cancer. 28976703

2018
Entrez Id: 2551
Gene Symbol: GABPA
GABPA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE These findings suggest that HO-1 may modulate the chemosensitivity of lung cancer A549 cells to cisplatin through the MAPK-Nrf2 pathway. 18006113

2008
Entrez Id: 2551
Gene Symbol: GABPA
GABPA
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.100 Biomarker BEFREE Finally, Nrf2 seems to be essential for the hyper proliferation of lung cancer cells in the absence of EZH2. 24928441

2014