×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Hereditary Diffuse Gastric Cancer
0.360
Biomarker
CTD_human
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer.
24816253 2014
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Hereditary Diffuse Gastric Cancer
0.360
Biomarker
CTD_human
Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes.
22484628 2012
×
Entrez Id: 1495
Gene Symbol: CTNNA1
CTNNA1
Hereditary Diffuse Gastric Cancer
0.340
GeneticVariation
ORPHANET
In HDGC families lacking CDH1 mutations, testing of CTNNA1 and other tumor suppressor genes should be considered.
26182300 2015
×
Entrez Id: 1495
Gene Symbol: CTNNA1
CTNNA1
Hereditary Diffuse Gastric Cancer
0.340
GeneticVariation
ORPHANET
Recognition of and recent issues in hereditary diffuse gastric cancer.
26049741 2015
×
Entrez Id: 1495
Gene Symbol: CTNNA1
CTNNA1
Hereditary Diffuse Gastric Cancer
0.340
GeneticVariation
ORPHANET
An α-E-catenin (CTNNA1 ) mutation in hereditary diffuse gastric cancer .
23208944 2013
×
Entrez Id: 4595
Gene Symbol: MUTYH
MUTYH
Hereditary Diffuse Gastric Cancer
0.320
Biomarker
CTD_human
×
Entrez Id: 324
Gene Symbol: APC
APC
Hereditary Diffuse Gastric Cancer
0.320
Biomarker
CTD_human
×
Entrez Id: 9064
Gene Symbol: MAP3K6
MAP3K6
Hereditary Diffuse Gastric Cancer
0.310
GermlineCausalMutation
ORPHANET
These findings, together with previous evidence from mouse models that MAP3K6 acts as a tumor suppressor, and studies showing the presence of somatic mutations in MAP3K6 in non-hereditary gastric cancers and gastric cancer cell lines, point towards MAP3K6 variants as a predisposing factor for FGC .
25340522 2014
×
Entrez Id: 4609
Gene Symbol: MYC
MYC
Hereditary Diffuse Gastric Cancer
0.310
Biomarker
CTD_human
Three-gene predictor of clinical outcome for gastric cancer patients treated with chemotherapy.
21173787 2012
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Hereditary Diffuse Gastric Cancer
0.310
Biomarker
CTD_human
Three-gene predictor of clinical outcome for gastric cancer patients treated with chemotherapy.
21173787 2012
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Hereditary Diffuse Gastric Cancer
0.310
Therapeutic
CTD_human
Three-gene predictor of clinical outcome for gastric cancer patients treated with chemotherapy.
21173787 2012
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Hereditary Diffuse Gastric Cancer
0.310
Biomarker
CTD_human
A gene expression signature of acquired chemoresistance to cisplatin and fluorouracil combination chemotherapy in gastric cancer patients.
21364753 2011
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Hereditary Diffuse Gastric Cancer
0.310
Biomarker
CTD_human
MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib.
22042947 2011
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Hereditary Diffuse Gastric Cancer
0.310
Therapeutic
CTD_human
MET amplification identifies a small and aggressive subgroup of esophagogastric adenocarcinoma with evidence of responsiveness to crizotinib.
22042947 2011
×
Entrez Id: 4609
Gene Symbol: MYC
MYC
Hereditary Diffuse Gastric Cancer
0.310
Biomarker
CTD_human
Folate levels in mucosal tissue but not methylenetetrahydrofolate reductase polymorphisms are associated with gastric carcinogenesis.
17171786 2006
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Hereditary Diffuse Gastric Cancer
0.310
Therapeutic
CTD_human
"Gefitinib (""Iressa"", ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells."
15723263 2005
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Hereditary Diffuse Gastric Cancer
0.310
Biomarker
CTD_human
"Gefitinib (""Iressa"", ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells."
15723263 2005
×
Entrez Id: 1893
Gene Symbol: ECM1
ECM1
Hereditary Diffuse Gastric Cancer
0.300
Biomarker
CTD_human
MiR-92a antagonized the facilitation effect of extracellular matrix protein 1 in GC metastasis through targeting its 3'UTR region.
31472228 2019
×
Entrez Id: 4853
Gene Symbol: NOTCH2
NOTCH2
Hereditary Diffuse Gastric Cancer
0.300
Biomarker
CTD_human
Long Noncoding RNA (lncRNA) MIR22HG Suppresses Gastric Cancer Progression through Attenuating NOTCH2 Signaling.
30670679 2019
×
Entrez Id: 84981
Gene Symbol: MIR22HG
MIR22HG
Hereditary Diffuse Gastric Cancer
0.300
Biomarker
CTD_human
Long Noncoding RNA (lncRNA) MIR22HG Suppresses Gastric Cancer Progression through Attenuating NOTCH2 Signaling.
30670679 2019
ZNF667-AS1
Hereditary Diffuse Gastric Cancer
0.300
Biomarker
CTD_human
Epigenetic silencing of lncRNA MORT in 16 TCGA cancer types.
29707199 2018
×
Entrez Id: 9123
Gene Symbol: SLC16A3
SLC16A3
Hereditary Diffuse Gastric Cancer
0.300
Biomarker
CTD_human
MCT4 as a potential therapeutic target for metastatic gastric cancer with peritoneal carcinomatosis.
27224918 2016
×
Entrez Id: 8314
Gene Symbol: BAP1
BAP1
Hereditary Diffuse Gastric Cancer
0.300
Biomarker
CTD_human
Germline BAP1 Mutational Landscape of Asbestos-Exposed Malignant Mesothelioma Patients with Family History of Cancer.
26719535 2016
×
Entrez Id: 100507056
Gene Symbol: CCAT1
CCAT1
Hereditary Diffuse Gastric Cancer
0.300
Biomarker
CTD_human
CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer.
26752646 2016
×
Entrez Id: 472
Gene Symbol: ATM
ATM
Hereditary Diffuse Gastric Cancer
0.300
Biomarker
CTD_human
Loss-of-function variants in ATM confer risk of gastric cancer.
26098866 2015