Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 AlteredExpression BEFREE Here, we report that VTRNA2-1-5p directly targeted p53 expression and functioned as an oncomir in cervical cancer. 26318295

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE Several factors may contribute to cervical cancer (CC) development, including genetic variants such as TP53 and MDM2 gene polymorphisms. 25181402

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE To investigate the effect of recombinant human p53 adenovirus injection combined with paclitaxel on human cervical cancer HeLa cell proliferation, apoptosis and expression of vascular endothelial growth factor (VEGF). 25855930

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE These data suggest that there are significant associations between the miR-502-binding site SNP in the 3'-UTR of SET8 and the TP53 codon 72 polymorphism with cervical cancer in Chinese, and there is a gene-gene interaction. 25169478

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE The p53 target gene WIG-1 (ZMAT3) is located in chromosomal region 3q26, that is frequently amplified in human tumors, including cervical cancer. 25379706

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE Association of TP53 codon 72 and intron 3 16-bp Ins/Del polymorphisms with cervical cancer risk. 24782034

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE The results indicated that the polymorphism in TP53 (rs1042522) might be associated with risk of cervical cancer development in HPV16 infected women. 23534750

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 AlteredExpression BEFREE Plasmid-based E6-specific siRNA and co-expression of wild-type p53 suppresses the growth of cervical cancer in vitro and in vivo. 23435374

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 AlteredExpression BEFREE 1) To analyze the expression of Ki-67, p53 and p16(INK4a) in cervical cancer, 2) to correlate the relative expression of these proteins as well as clinical parameters with the stage of disease, and 3) to determine the HPV DNA prevalence and subtype distribution. 23505442

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE In conclusion, Arginine at codon72 of p53 and GG genotype at 309 in P2 of MDM2 together reveal a direct proportionality with the tumor grade of cervical cancer along with HPV infection in postmenopausal women. 23210739

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE Among the six hot-spot codons of TP53 gene, three codons (175, 248 and 273) were the most commonly mutated in both types of cervical cancer, one codon (249) mainly in squamous cell carcinoma and one codon (282) only in adenocarcinoma. 23168175

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE Results from the current meta-analysis suggests that p53 codon 72 polymorphism might be associated with increased risk of cervical cancer, especially among Indians. 23244080

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE Here we report that differential regulation of pro- and anti-p53 setups not only upregulates p53 transcription but also stabilizes and activates p53 protein to ensure p53-induced apoptosis in HPV-18-infected cervical cancer. 21765464

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE Although the p53 arginine allele is itself an important risk factor for cervical cancer, the combined risk with LOH of Rb, which appears to be greater, might indicate a possible epistatic effect of the two genes/polymorphisms. 22692183

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE Crucial role of TSC-22 in preventing the proteasomal degradation of p53 in cervical cancer. 22870275

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 PosttranslationalModification BEFREE This is also the first report on significant p53 hypermethylation in cervical cancer in any population. 22729911

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE This association was not seen in HPV-negative individuals. p53 Arg72Pro was not associated with the risk of cervical cancer or initiation of SIL in either HPV-positive or HPV-negative patient subsets. 23065429

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE In the present work, the exon 4 sequence of TP53 gene in CC and healthy Mexican-mestizo women were analyzed. 20661667

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE Cervical cancer is caused by human papilloma virus (HPV) expressing E6 and E7 oncoproteins, which are known to inactivate tumor suppressor proteins p53 and pRb, respectively. 21859835

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 AlteredExpression BEFREE In conclusion, this study provides evidence for elevated LAP2α expression in cervical cancer and suggests that E2F and p53 activities associate with the positive and negative regulation of LAP2α expression, respectively. 21990273

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE These results suggest that a heterozygous TP53 Arg72Pro genotype may contribute to cervical cancer susceptibility. 21665181

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE In additional, interaction between these p53 and p21 polymorphisms increased the risk of cervical cancer in a multiplicative manner, with the OR being 3.96 (95% CI, 1.51-10.41) for subjects carrying both p53 Arg/Arg and p21 Ser/Ser genotypes. 20732856

2010

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 AlteredExpression BEFREE The intratumoral delivery of exogenous E1A carried by SDION increases p53 expression but inhibits HER-2/neu expression, and enhances the radiosensitivity of human cervical cancer in xenograft mice. 20587666

2010

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE Thus, polymorphism of the p53 itself as well as in combination with HPV infection may not be a genetic risk for cervical cancer and therefore much attention should be paid to other risk factors such as sexual behavior and smoking. 19771536

2010

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE We show here that depleting cyclin B1 stabilizes and reactivates p53 in papillomavirus-infected cervical cancer cell lines HeLa and CaSki. 20661218

2010