Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2690
Gene Symbol: GHR
GHR
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 AlteredExpression BEFREE The delineation of the role of this repressosome complex in regulating tissue-specific expression of GHR in diabetes mellitus provides a molecular model for the role of GH in the genesis of certain microvascular complications of diabetes mellitus. 12529387

2003

Entrez Id: 2688
Gene Symbol: GH1
GH1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 Biomarker BEFREE The delineation of the role of this repressosome complex in regulating tissue-specific expression of GHR in diabetes mellitus provides a molecular model for the role of GH in the genesis of certain microvascular complications of diabetes mellitus. 12529387

2003

Entrez Id: 7045
Gene Symbol: TGFBI
TGFBI
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 Biomarker BEFREE Because TGF-beta plays an important role in diabetic complications and beta ig-h3 serves as a cell substrate, we hypothesized that diabetic conditions might increase beta ig-h3 synthesis in vascular smooth muscle cells (VSMCs), which may subsequently contribute to the pathogenesis of diabetic angiopathy. 12577311

2003

Entrez Id: 4846
Gene Symbol: NOS3
NOS3
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.030 GeneticVariation BEFREE To study putative associations of the ecNOS 4 a/b polymorphism with carotid artery intima-media thickness (IMT) and diabetic complications in young type-1 diabetic patients. 12605344

2003

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.070 GeneticVariation LHGDN Our results suggested that though TNF-alpha G-238A and G-308A polymorphisms were not involved in the pathogenesis of type 2 DM, type 2 diabetic patients carrying TNFA-A or TNF-308*2 genotype might be more susceptible to diabetic complications such as atherosclerosis. 12753658

2003

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.070 GeneticVariation BEFREE Our results suggested that though TNF-alpha G-238A and G-308A polymorphisms were not involved in the pathogenesis of type 2 DM, type 2 diabetic patients carrying TNFA-A or TNF-308*2 genotype might be more susceptible to diabetic complications such as atherosclerosis. 12753658

2003

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Together, these genetic studies strongly indicate that AR is an important target for the prevention of diabetic complications in human. 12871135

2003

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE The newly discovered RSOR has certain structural and functional similarities to AKR1B and seems to be relevant to the renal complications of diabetes mellitus. 12871137

2003

Entrez Id: 51738
Gene Symbol: GHRL
GHRL
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 GeneticVariation BEFREE The association between the Leu72Met polymorphism of the preproghrelin gene and diabetic complications was examined in patients with type 2 diabetes mellitus. 12974878

2003

Entrez Id: 4086
Gene Symbol: SMAD1
SMAD1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 AlteredExpression BEFREE These results suggest that the modulation of Smad1 expression is responsible for the initiation and progression of diabetic nephropathy and that blocking Smad1 signaling may be beneficial in preventing diabetic nephropathy and other various diabetic complications. 14732718

2004

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.370 Biomarker BEFREE Vascular endothelial growth factor (VEGF) is a potent angiogenic and vascular permeability factor and is implicated in both of these diabetes complications. 14988276

2004

Entrez Id: 1906
Gene Symbol: EDN1
EDN1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.020 Biomarker BEFREE Endothelin-1 (ET-1) is both a potent vasoconstrictor and mitogenic factor that has been implicated as a cause of the micro- and macrovascular complications of diabetes mellitus. 15010576

2004

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Aldose reductase catalyzes the first step in the polyol pathway and is thought to be involved in the pathogenesis of diabetic complications. 15094999

2004

Entrez Id: 7422
Gene Symbol: VEGFA
VEGFA
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.370 Biomarker BEFREE Thus, VEGF therapy may be useful in the treatment of diabetic complications characterized by impaired neovascularization. 15161630

2004

Entrez Id: 217
Gene Symbol: ALDH2
ALDH2
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.320 GeneticVariation BEFREE The first study (study 1) was to determine the association of ALDH2/AHD2 polymorphism with diabetic complications. 15318096

2004

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.040 GeneticVariation BEFREE A single-nucleotide polymorphism (SNP) G276T in the adiponectin gene has been associated with lower plasma adiponectin levels and insulin resistance, which are related to the prevalence of type 2 diabetes or diabetic complications of macroangiopathy. 15334388

2004

Entrez Id: 5972
Gene Symbol: REN
REN
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.050 Biomarker BEFREE Genes of the renin angiotensin system are potential candidate genes for diabetic complications. 15365253

2004

Entrez Id: 64122
Gene Symbol: FN3K
FN3K
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.030 AlteredExpression BEFREE The genes were expressed in all human tissues examined, with FN3K showing significantly higher levels in organs susceptible to nonenzymatic glycation and diabetic complications. 15381090

2004

Entrez Id: 4353
Gene Symbol: MPO
MPO
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 Biomarker LHGDN Leukocyte-derived myeloperoxidase amplifies high-glucose--induced endothelial dysfunction through interaction with high-glucose--stimulated, vascular non--leukocyte-derived reactive oxygen species. 15504976

2004

Entrez Id: 6464
Gene Symbol: SHC1
SHC1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.010 AlteredExpression BEFREE In conclusion, diabetes induces p66(shc) gene expression in circulating PBM; this up-regulation in expression is significantly associated with markers of oxidative stress. p66(shc) gene expression in PBM may represent a useful tool to investigate the oxidative stress involved in the pathogenesis of long-term diabetic complications. 15562031

2005

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.020 GeneticVariation BEFREE Subgrouping of the patients with respect to MTHFR genotype revealed similar metabolic variables and frequency of chronic complications of diabetes mellitus in groups. 15836661

2005

Entrez Id: 231
Gene Symbol: AKR1B1
AKR1B1
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.400 Biomarker BEFREE Discovery of 3-[(4,5,7-trifluorobenzothiazol-2-yl)methyl]indole-N-acetic acid (lidorestat) and congeners as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications. 15857120

2005

Entrez Id: 177
Gene Symbol: AGER
AGER
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.100 GeneticVariation BEFREE Genetic variability in the RAGE gene: possible implications for nutrigenetics, nutrigenomics, and understanding the susceptibility to diabetic complications. 15937999

2005

Entrez Id: 5891
Gene Symbol: MOK
MOK
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.030 GeneticVariation BEFREE Genetic variability in the RAGE gene: possible implications for nutrigenetics, nutrigenomics, and understanding the susceptibility to diabetic complications. 15937999

2005

Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
CUI: C0342257
Disease: Complications of Diabetes Mellitus
Complications of Diabetes Mellitus
0.040 GeneticVariation BEFREE No association of the 94T/G polymorphism in the adiponectin gene with diabetic complications. 15955133

2005