×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
A Phase II Study of FOLFOXIRI Plus Panitumumab Followed by Evaluation for Resection in Patients With Metastatic KRAS Wild-Type Colorectal Cancer With Liver Metastases Only.
26911408 2016
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
The intent of this study, has been to evaluate the associations between KRAS gene mutations and clinicopathological features and survival times in Turkish colorectal cancer patients.
27072218 2016
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
We investigated the occurrence of exon 15 BRAF and KRAS codon 12 mutations among Greek patients with colorectal cancer .
17393356 2007
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
MicroRNA‑337 inhibits colorectal cancer progression by directly targeting KRAS and suppressing the AKT and ERK pathways.
29048669 2017
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
This study assessed the prognostic impact of specific KRAS mutations on survival for patients with colorectal cancer .
28208157 2017
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
An electrochemical biosensor based on functional composite nanofibers for hybridization detection of specific K-ras gene that is highly associated with colorectal cancer via multiple signal amplification strategy has been developed.
25173509 2014
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
Mutations within the KRAS proto-oncogene have predictive value but are of uncertain prognostic value in the treatment of advanced colorectal cancer .
20008640 2010
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
KRAS allel-specific activity of sunitinib in an isogenic disease model of colorectal cancer .23455880 2013
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
The mutation rates of EGFR in non-small cell lung cancer and KRAS in colorectal cancer of Chinese patients as detected by pyrosequencing using a novel dispensation order.
26081767 2015
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
K-ras gene mutations contribute to the pathogenesis of colorectal cancer .24675495 2014
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
Vitamin D receptor expression is associated with PIK3CA and KRAS mutations in colorectal cancer .
19789368 2009
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of colon and/or rectum
0.100
AlteredExpression
BEFREE
Herein, we demonstrate that the presence of an oncogenic KRAS allele results in elevated levels of GTP-bound N-RAS (N-RAS.GTP) in two human colorectal cancer cell lines, HCT 116 and DLD-1, compared to their isogenic counterparts in which the mutant KRAS allele has been disrupted by homologous recombination.
17130841 2007
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
KRAS mutation detection and prognostic potential in sporadic colorectal cancer using high-resolution melting analysis.20959826 2010
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
The relationship between KRAS and NF-κB in colorectal cancer is not clear.
22327383 2012
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
Predicting cetuximab accumulation in KRAS wild-type and KRAS mutant colorectal cancer using 64Cu-labeled cetuximab positron emission tomography.
22126621 2012
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
One-carbon metabolism biomarkers and genetic variants in relation to colorectal cancer risk by KRAS and BRAF mutation status.
29694444 2018
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
KRAS testing and its importance in colorectal cancer .20425075 2010
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
Anti-EGFR targeted therapy is of increasing importance in advanced colorectal cancer and prior KRAS mutation testing is mandatory for therapy.
27064574 2016
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
Association between KRAS G13D mutations and anastomotic recurrence in colorectal cancer : Two case reports.
30896620 2019
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
Toll like receptor 3 as an immunotherapeutic target for KRAS mutated colorectal cancer .
28422714 2017
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of colon and/or rectum
0.100
Biomarker
BEFREE
These data suggest DEK overexpression as a crucial event for the emergence of an aggressive phenotype in colorectal cancer and its potential role as biomarker for irinotecan response in those patients with KRAS wild-type status.
25515240 2014
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
Although the overall frequency of KRAS mutations (36.6%) seemed to be similar to those reported for other populations, the rate of point mutations at codon 13 was significantly lower (12%) in Greek patients with colorectal cancer and associated with male gender (P < 0.05).
26681025 2015
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
Combination of trametinib and palbociclib was well tolerated and highly efficacious in all three KRAS -mutant colorectal cancer PDX models tested.
26369631 2016
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
Comparison of KRAS mutation tests in colorectal cancer patients.
21699410 2011
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Malignant neoplasm of colon and/or rectum
0.100
GeneticVariation
BEFREE
This study included the results of KRAS mutation tests for colorectal cancer in 401 specimens.
30846412 2019