Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 AlteredExpression BEFREE The combined determination of Ebp1 and p53 expression levels in cervical cancer patients could support the effective prediction of metastatic potential and patient prognosis. 26436510

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 Biomarker BEFREE To investigate the effect of recombinant human p53 adenovirus injection combined with paclitaxel on human cervical cancer HeLa cell proliferation, apoptosis and expression of vascular endothelial growth factor (VEGF). 25855930

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE Several factors may contribute to cervical cancer (CC) development, including genetic variants such as TP53 and MDM2 gene polymorphisms. 25181402

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE This study aims to investigate whether the genotype distribution of p53 codon 72 may be a risk factor for cervical cancer among Gabonese women. 25502079

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 Biomarker BEFREE Expression of the p53 target Wig-1 is associated with HPV status and patient survival in cervical carcinoma. 25379706

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE These data suggest that there are significant associations between the miR-502-binding site SNP in the 3'-UTR of SET8 and the TP53 codon 72 polymorphism with cervical cancer in Chinese, and there is a gene-gene interaction. 25169478

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE Association of TP53 codon 72 and intron 3 16-bp Ins/Del polymorphisms with cervical cancer risk. 24782034

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE Among the six hot-spot codons of TP53 gene, three codons (175, 248 and 273) were the most commonly mutated in both types of cervical cancer, one codon (249) mainly in squamous cell carcinoma and one codon (282) only in adenocarcinoma. 23168175

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 AlteredExpression BEFREE 1) To analyze the expression of Ki-67, p53 and p16(INK4a) in cervical cancer, 2) to correlate the relative expression of these proteins as well as clinical parameters with the stage of disease, and 3) to determine the HPV DNA prevalence and subtype distribution. 23505442

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE The results indicated that the polymorphism in TP53 (rs1042522) might be associated with risk of cervical cancer development in HPV16 infected women. 23534750

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE The aim of this study was to investigate a role of the TP53 codon 72 polymorphism in cervical carcinoma development in Serbian women. 23483183

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 AlteredExpression BEFREE Plasmid-based E6-specific siRNA and co-expression of wild-type p53 suppresses the growth of cervical cancer in vitro and in vivo. 23435374

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE In conclusion, Arginine at codon72 of p53 and GG genotype at 309 in P2 of MDM2 together reveal a direct proportionality with the tumor grade of cervical cancer along with HPV infection in postmenopausal women. 23210739

2013

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE Although the p53 arginine allele is itself an important risk factor for cervical cancer, the combined risk with LOH of Rb, which appears to be greater, might indicate a possible epistatic effect of the two genes/polymorphisms. 22692183

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 Biomarker BEFREE Here we report that differential regulation of pro- and anti-p53 setups not only upregulates p53 transcription but also stabilizes and activates p53 protein to ensure p53-induced apoptosis in HPV-18-infected cervical cancer. 21765464

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 PosttranslationalModification BEFREE This is also the first report on significant p53 hypermethylation in cervical cancer in any population. 22729911

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 AlteredExpression BEFREE The present results show that PAI-1 overexpression is associated with nonhomologous end-joining DNA repair down-regulation (low Ku70/80 expression) and with increased p53 and cyclin D1 expression, and they suggest that PAI-1 plays a role in the tumor behavior in cervical carcinoma. 23111469

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE This association was not seen in HPV-negative individuals. p53 Arg72Pro was not associated with the risk of cervical cancer or initiation of SIL in either HPV-positive or HPV-negative patient subsets. 23065429

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE Results from the current meta-analysis suggests that p53 codon 72 polymorphism might be associated with increased risk of cervical cancer, especially among Indians. 23244080

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 Biomarker BEFREE Crucial role of TSC-22 in preventing the proteasomal degradation of p53 in cervical cancer. 22870275

2012

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 AlteredExpression BEFREE Accordingly, these data demonstrate that the anticancer activity of B1 is associated with the activation of p53 and the release of cytochrome c, which suggest that B1 might have therapeutic potential against cervix carcinoma as an effective lead compound. 20179988

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE In the present work, the exon 4 sequence of TP53 gene in CC and healthy Mexican-mestizo women were analyzed. 20661667

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 Biomarker BEFREE Cervical cancer is caused by human papilloma virus (HPV) expressing E6 and E7 oncoproteins, which are known to inactivate tumor suppressor proteins p53 and pRb, respectively. 21859835

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 GeneticVariation BEFREE These results suggest that a heterozygous TP53 Arg72Pro genotype may contribute to cervical cancer susceptibility. 21665181

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma
0.500 Biomarker BEFREE The E6 oncogene degrades p53 thereby modulating a large set of p53 target genes as shown previously in the cervical carcinoma cell line HeLa. 21980285

2011