×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of ovary
0.100
Biomarker
BEFREE
IGF/PI3K /AKT signaling pathway also plays certain roles in the program and regulation of human breast cancer and ovary cancer .
22094188 2012
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of ovary
0.100
Biomarker
BEFREE
We assayed a number of food phytochemicals with reported PI3K inhibitory ability to identify candidates that can influence CDDP treatment outcomes in chemoresistant OVCA cell lines.
24247248 2014
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of ovary
0.100
Biomarker
BEFREE
The PI3K /AKT/mTOR pathway as a therapeutic target in ovarian cancer .
25677064 2015
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of ovary
0.100
Biomarker
BEFREE
The Potential of PI3K /AKT/mTOR Signaling as a Druggable Target for Endometrial and Ovarian Carcinomas .
31752654 2019
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of ovary
0.100
Biomarker
BEFREE
This review focuses on recent research on the PI3K /AKT/mTOR pathway and its role in the progression and tumorigensis of ovarian cancer .
23591839 2013
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of ovary
0.100
Biomarker
BEFREE
Estrogen receptor modulators genistein, daidzein and ERB-041 inhibit cell migration, invasion, proliferation and sphere formation via modulation of FAK and PI3K /AKT signaling in ovarian cancer .
29743815 2018
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of ovary
0.100
Biomarker
BEFREE
The phosphatidylinositol 3-kinase (PI3K ) pathway is one of the critical signaling cascades playing important roles in the chemoresistance of human cancer cells, including ovarian cancer .
23371322 2013
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of ovary
0.100
Biomarker
BEFREE
Aberrations within the phosphoinositide-3-kinase (PI3K ) pathway occur in greater than 45% of ovarian carcinomas .
21970855 2011
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of ovary
0.100
Biomarker
BEFREE
Activation of the FOXM1 signaling pathway and the PI3K /AKT/mTOR signaling pathway is associated with poor prognosis in ovarian cancer .
30129654 2018
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of ovary
0.100
AlteredExpression
BEFREE
Conditional suppression of functional p53 increased p110alpha transcripts, protein levels and PI3K activity in immortalized, non-tumorigenic ovarian surface epithelial (OSE) cells, the precursors of ovarian carcinoma .
18270270 2008
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of ovary
0.100
Biomarker
BEFREE
Overexpression of SOX2 is involved in paclitaxel resistance of ovarian cancer via the PI3K /Akt pathway.
26159849 2015
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of ovary
0.100
Biomarker
BEFREE
Effect of combined inhibition of p110 alpha PI3K isoform and STAT3 pathway in ovarian cancer platinum-based resistance.
29930760 2018
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of ovary
0.100
Biomarker
BEFREE
Consequently, the addition of a PI3K inhibitor to CDDP-based chemotherapy may have a more beneficial application for ovarian cancer therapy.
23970345 2013
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of ovary
0.100
Biomarker
BEFREE
CEMIP promotes ovarian cancer development and progression via the PI3K /AKT signaling pathway.
30925458 2019
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of ovary
0.100
Biomarker
BEFREE
miR-214 targets the PTEN-mediated PI3K /Akt signaling pathway and regulates cell proliferation and apoptosis in ovarian cancer .
29113199 2017
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of ovary
0.100
Biomarker
BEFREE
Inhibiting the PI3K /AKT pathway may be a useful treatment for ovarian carcinoma .
25216292 2014
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of ovary
0.100
Biomarker
BEFREE
We propose that dual PI3K and mTOR inhibition using NVP-BEZ235 may be an effective novel therapeutic approach in patients with ovarian cancer .
21372221 2011
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of ovary
0.100
Biomarker
BEFREE
Targeting EGFR and PI3K pathways in ovarian cancer .
24022196 2013
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of ovary
0.100
Biomarker
BEFREE
This study aimed to identify secreted proteins regulated by the PI3K pathway in ovarian cancer cell lines.
16452192 2006
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of ovary
0.100
GeneticVariation
BEFREE
Although many tumors presented a single lesion (28/93, of which 23 overexpressed PIK3CA, 1 overexpressed AKT and 4 had lost PTEN), many OC (35/93) presented multiple alterations within the PI3K pathway.
23408974 2013
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of ovary
0.100
Biomarker
BEFREE
PI3K -AKT-mTOR and NFκB Pathways in Ovarian Cancer : Implications for Targeted Therapeutics.31284467 2019
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of ovary
0.100
Biomarker
BEFREE
Oncogenic changes of genes of the PI3K pathway are one of the potential genetic determinants of ovarian carcinomas .
31731647 2019
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of ovary
0.100
AlteredExpression
BEFREE
Notably, peptide 17, a YAP inhibitor, exerted a significant attenuating effect on OC progression by diminishing the activation of the PI3K /Akt/mTOR pathway in vitro as well as in vivo.
31638241 2019
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of ovary
0.100
Biomarker
BEFREE
In this study, we have investigated the expression profile of 22 genes involved in the PI3K -AKT pathway in 26 high-grade ovarian carcinomas (19 serous and 7 clear cell carcinomas).
21317880 2011
×
Entrez Id: 5294
Gene Symbol: PIK3CG
PIK3CG
Malignant neoplasm of ovary
0.100
Biomarker
BEFREE
CAF: cancer-associated fibroblasts; COG: Cluster of Orthologous Groups; DEA: disease enrichment analysis; EOC: epithelial ovarian carcinoma; ESCC: oesophageal squamous cell carcinoma; GSI: gamma secretase inhibitor; GO: Gene Ontology; GSEA: gene set enrichment analyzes; HAS: Hungarian Academy of Sciences; lncRNAs: long non-coding RNAs; MAPK/ERK: mitogen-activated protein kinase/extracellular signal-regulated kinases; NGS: next-generation sequencing; ncRNAs: non-coding RNAs; OvC: ovarian cancer ; PI3K /Akt/mTOR: phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin; RT-PCR: real-time polymerase chain reaction; SNP: single nucleotide polymorphism; TF: transcription factor; TGF-β: transforming growth factor-β.
28574782 2017