Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.100 CausalMutation CLINVAR Genetic testing for RAD51C mutations: in the clinic and community. 25470109

2015

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.100 CausalMutation CLINVAR Contribution of Germline Mutations in the RAD51B, RAD51C, and RAD51D Genes to Ovarian Cancer in the Population. 26261251

2015

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.100 GeneticVariation CLINVAR Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart. 26354865

2015

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.100 CausalMutation CLINVAR Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer. 25452441

2015

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.100 GeneticVariation CLINVAR Enhanced non-homologous end joining contributes toward synthetic lethality of pathological RAD51C mutants with poly (ADP-ribose) polymerase. 25292178

2015

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.100 GeneticVariation CLINVAR Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair. 24141787

2014

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.100 CausalMutation CLINVAR Next-generation sequencing for the diagnosis of hereditary breast and ovarian cancer using genomic capture targeting multiple candidate genes. 24549055

2014

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.100 GeneticVariation CLINVAR Pathological features of breast and ovarian cancers in RAD51C germline mutation carriers. 24993905

2014

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.100 CausalMutation CLINVAR RAD51C--a new human cancer susceptibility gene for sporadic squamous cell carcinoma of the head and neck (HNSCC). 24315737

2014

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.100 CausalMutation CLINVAR Pathological features of breast and ovarian cancers in RAD51C germline mutation carriers. 24993905

2014

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.100 CausalMutation CLINVAR Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas. 24240112

2014

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.100 CausalMutation CLINVAR Deleterious RAD51C germline mutations rarely predispose to breast and ovarian cancer in Pakistan. 24800917

2014

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.100 CausalMutation CLINVAR RAD51C germline mutations found in Spanish site-specific breast cancer and breast-ovarian cancer families. 25086635

2014

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.100 GeneticVariation CLINVAR Germline mutation in the RAD51B gene confers predisposition to breast cancer. 24139550

2013

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.100 GeneticVariation CLINVAR Regulation of nonsense-mediated mRNA decay: implications for physiology and disease. 23500037

2013

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.100 GeneticVariation CLINVAR Germline RAD51C mutations in ovarian cancer susceptibility. 22725699

2013

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.100 CausalMutation CLINVAR Germline RAD51C mutations in ovarian cancer susceptibility. 22725699

2013

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.100 GeneticVariation CLINVAR ATM- and ATR-mediated phosphorylation of XRCC3 regulates DNA double-strand break-induced checkpoint activation and repair. 23438602

2013

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.100 CausalMutation CLINVAR Germline mutation in the RAD51B gene confers predisposition to breast cancer. 24139550

2013

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.100 CausalMutation CLINVAR Germline mutations in RAD51C in Jewish high cancer risk families. 23117857

2012

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.100 CausalMutation CLINVAR Germline RAD51C mutations confer susceptibility to ovarian cancer. 22538716

2012

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.100 GeneticVariation CLINVAR Germline RAD51C mutations confer susceptibility to ovarian cancer. 22538716

2012

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.100 GeneticVariation CLINVAR Distinct roles of FANCO/RAD51C protein in DNA damage signaling and repair: implications for Fanconi anemia and breast cancer susceptibility. 22167183

2012

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.100 CausalMutation CLINVAR Screening of Finnish RAD51C founder mutations in prostate and colorectal cancer patients. 23176254

2012

Entrez Id: 5889
Gene Symbol: RAD51C
RAD51C
CUI: C0027672
Disease: Neoplastic Syndromes, Hereditary
Neoplastic Syndromes, Hereditary
0.100 GeneticVariation CLINVAR Germline mutations in RAD51C in Jewish high cancer risk families. 23117857

2012