×
Entrez Id:
2956
Gene Symbol:
MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
An Ashkenazi founder mutation in the MSH6 gene leading to HNPCC.
19851887
2010
×
Entrez Id:
2956
Gene Symbol:
MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Major contribution from recurrent alterations and MSH6 mutations in the Danish Lynch syndrome population.
18566915
2009
×
Entrez Id:
2956
Gene Symbol:
MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Two Swedish founder MSH6 mutations, one nonsense and one missense, conferring high cumulative risk of Lynch syndrome.
16283884
2005
×
Entrez Id:
2956
Gene Symbol:
MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Characterization of two Ashkenazi Jewish founder mutations in MSH6 gene causing Lynch syndrome.
21155762
2011
×
Entrez Id:
2956
Gene Symbol:
MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Patients with an unexplained microsatellite instable tumour have a low risk of familial cancer.
17453009
2007
×
Entrez Id:
2956
Gene Symbol:
MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Germline mutations in a polycytosine repeat of the hMSH6 gene in Korean hereditary nonpolyposis colorectal cancer.
9929971
1999
×
Entrez Id:
2956
Gene Symbol:
MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Prevalence of alterations in DNA mismatch repair genes in patients with young-onset colorectal cancer.
21056691
2011
×
Entrez Id:
2956
Gene Symbol:
MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
MSH6 germline mutations are rare in colorectal cancer families.
14520694
2003
×
Entrez Id:
2956
Gene Symbol:
MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
No association between MUTYH and MSH6 germline mutations in 64 HNPCC patients.
18301448
2008
×
Entrez Id:
2956
Gene Symbol:
MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database.
24362816
2014
×
Entrez Id:
2956
Gene Symbol:
MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Germ-line msh6 mutations in colorectal cancer families.
10537275
1999
×
Entrez Id:
2956
Gene Symbol:
MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
MSH6 and PMS2 mutation positive Australian Lynch syndrome families: novel mutations, cancer risk and age of diagnosis of colorectal cancer.
20487569
2010
×
Entrez Id:
2956
Gene Symbol:
MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Mismatch repair gene mutation spectrum in the Swedish Lynch syndrome population.
27601186
2016
×
Entrez Id:
2956
Gene Symbol:
MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Mutation analysis of the MLH1, MSH2 and MSH6 genes in patients with double primary cancers of the colorectum and the endometrium: a population-based study in northern Sweden.
14961575
2004
×
Entrez Id:
2956
Gene Symbol:
MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing.
22006311
2011
×
Entrez Id:
2956
Gene Symbol:
MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Identification of a Variety of Mutations in Cancer Predisposition Genes in Patients With Suspected Lynch Syndrome.
25980754
2015
×
Entrez Id:
2956
Gene Symbol:
MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mismatch repair genes to ovarian cancer in the population.
24728189
2014
×
Entrez Id:
2956
Gene Symbol:
MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Mutation spectrum in HNPCC in the Israeli population.
18389388
2008
×
Entrez Id:
2956
Gene Symbol:
MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
CoDP: predicting the impact of unclassified genetic variants in MSH6 by the combination of different properties of the protein.
23621914
2013
×
Entrez Id:
2956
Gene Symbol:
MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Risks of Lynch syndrome cancers for MSH6 mutation carriers.
20028993
2010
×
Entrez Id:
2956
Gene Symbol:
MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
MSH6 mutations are frequent in hereditary nonpolyposis colorectal cancer families with normal pMSH6 expression as detected by immunohistochemistry.
22495361
2012
×
Entrez Id:
2956
Gene Symbol:
MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
A high incidence of MSH6 mutations in Amsterdam criteria II-negative families tested in a diagnostic setting.
18625694
2008
×
Entrez Id:
2956
Gene Symbol:
MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing.
26681312
2016
×
Entrez Id:
2956
Gene Symbol:
MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Cancer risk in hereditary nonpolyposis colorectal cancer due to MSH6 mutations: impact on counseling and surveillance.
15236168
2004
×
Entrez Id:
2956
Gene Symbol:
MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Current clinical criteria for Lynch syndrome are not sensitive enough to identify MSH6 mutation carriers.
20587412
2010