Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE There appears to be evidence for interaction between amount of smoking, the GSTP1 exon 5 polymorphism, and risk of lung cancer in whites. 19240225

2009

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE Lung cancer risk associated with individual SNPs was seen for GSTP1 [A allele; odds ratio (OR) = 1.85; 95% confidence interval (CI), 1.04-3.27] and XRCC1 (A/A genotype; OR = 1.68; 95% CI, 1.01-2.79) in white women and CYP1B1 (G allele; OR = 11.1; 95% CI, 1.18-104) in black women smokers. 19174490

2009

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE There was a marginally significant association between LC and GSTT1 null genotype (OR = 1.3; 95% CI: 1.0-1.7) while no significant risk association was found between GSTP1 polymorphism and LC. 19009239

2009

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE The study has been extended to investigate the potential role of polymorphism in GSTP1 alone or in combination with the status of GSTM1 and GSTT1 genes in the likelihood of development of lung cancer. 18415801

2008

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE The aim of our study was to measure the frequency of GSTM1, GSTT1, GSTP1*B and p53 gene polymorphisms in a Brazilian population and determine the possible contribution of these genetic variations to LC risk. 18280004

2008

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE However, only four of the previously reported associations with polymorphisms in the GSTP1 (Ala14Val), SOD2 (Val16Ala), EPHX1 (His139Arg) genes and the NAT1 fast acetylator phenotype remained significantly associated with lung cancer. 18258609

2008

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE The polymorphisms of GSTP1 Ile105Val and MPO G-463A showed no significant association with lung cancer. 17980933

2008

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE The GSTT1 null genotype was also associated with an increased lung cancer risk (OR, 1.49; 95% CI, 1.17-1.89; p=0.001), but no association was observed for the GSTP1 105Val allele. 17428724

2008

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE After combination study of the three gene-polymorphism, the subjects who were most different with the reference, i.e. had the mutant allele of the GSTP1 and CYP1A1 and homozygous wild type of the MPO, showed approximately 5-fold-higher risk for lung cancer than the reference (95% CI, 2.05-12.05). 17428572

2007

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE Interactions between GSTM1, GSTT1 and GSTP1 polymorphisms and smoking and intake of fruit and vegetables in relation to lung cancer. 17123660

2007

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE The GSTP1 GG genotype was not associated with an overall increased risk of lung cancer (adjusted odds ratio, 1.02; 95% confidence interval [95% CI], 0.78-1.34) compared with the GSTP1 AA genotype. 16933328

2006

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE Furthermore, individuals possessing combined genotypes of N-acetyltransferase 2 (NAT2) rapid acetylator, GSTP1 mutant and both GSTT1(-) and GSTM1(-) have a remarkably higher lung cancer risk than those carrying combined NAT2 slow acetylator genotype, GSTP1 wild genotype and both GSTT1(+) and GSTM1(+) genotypes. 16788248

2006

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE The risk of lung cancer is not strongly associated with the I105V and A114V polymorphisms in the GSTP1 gene or with GSTM3 intron 6 polymorphism. 16509765

2006

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE The interaction between GSTP1 105Val mutation and smoking in the development of lung cancer were not detected, nor was hOGG1 326Cys mutation. 15896461

2005

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE No significant single gene associations between GSTM1, GSTT1 or GSTP1 and early-onset lung cancer were identified in Caucasians, after adjusting for age, sex, pack years and family history of lung cancer. 15661806

2005

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE Individuals in this high ETS exposure category carrying the GSTM1 null and the GSTP1 Val allele were at over 4-fold increased risk of developing lung cancer (OR = 4.56, 95% CI: 1.21-17.21). 15528218

2005

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE GSTM1 null genotype, combined GSTT1 and GSTM1 null genotype and GSTP1 Val105/Val105 genotype did not confer any increase risk for lung cancer. 15246186

2004

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE In the current German study we investigated the role of GSTM1, GSTT1 and GSTP1 polymorphisms as a genetic modifier of risk for individuals with lung cancer as susceptible genotypes especially in relation to tobacco smoking. 15105047

2004

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE The results showed a 2.4-fold (CI = 1.31-4.41) increased risk of lung cancer in GSTT1 null-genotype carriers but no significant effects of the polymorphisms in GSTM1, GSTM3, GSTP1-105 or GSTP1-114. 15069685

2004

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE The estimated lung cancer risk for GSTM1 null, GSTP1 Ile/Val and GSTP1 Val/Val combined genotype was 1.44 (95% CI: 0.73-2.83), suggesting the absence of modifying effect of defective GSTM1 and GSTP1 alleles on lung cancer predisposition. 14628089

2003

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE The GSTP1 GG genotype approximately doubled the lung cancer risk associated with pack-years. 14501269

2003

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE Recent investigations have shown that the GSTM1-null genotype combined with CYP1A1, NAT2, or GSTP1 polymorphisms confers a greater risk of lung cancer than the GSTM1-null genotype alone. 12894585

2003

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE GSTT1 was not associated with lung cancer risk and GSTP1 val was non-significantly associated with a modest reduction in risk, particularly among heavy smokers. 12781423

2003

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 Biomarker BEFREE We assessed the association of three genetic polymorphisms, NAD(P)H quinone oxidoreductase (NQO1), Glutathione-S-transferase P1 (GSTP1), and manganese superoxide dismutase (MnSOD), with lung cancer risk in 198 cases and 332 controls in Taiwan. 12711112

2003

Entrez Id: 2950
Gene Symbol: GSTP1
GSTP1
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.600 GeneticVariation BEFREE Utilizing a hospital-based case-control study, we investigated the association between GSTP1 polymorphisms at exons 5 and 6 with lung cancer risk. 12660004

2003