Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE RLIP (Ral-interacting protein)-76/RalBP11 (Ral-binding protein-1), a multifunctional protein and stress-inducible non-ABC transporter, have been proven to serve as a critical role in cancer development and progression; however, little is known about the pathological role of RLIP76 in breast cancer patients. 26125275

2015

Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE Here, we investigated the effect of the ABCG2 substrate topotecan on the MCF-7 breast cancer cell line and analyzed CD24, CD44, EpCAM, and HER2 expression by flow cytometry. 25892097

2015

Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE Our results support the hypothesis that the presence of ABCG2(+) cells in breast carcinomas is a marker of resistance to chemotherapy, and based on in vitro assays and the genetic profile, we show, for the first time, that ABCG2 protein can be used as an independent marker for TIC identification in breast cancer. 26091795

2015

Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 GeneticVariation BEFREE These results suggested that the ABCG2 polymorphisms might be a candidate pharmacogenomic factor to assess susceptibility and prognosis for breast carcinoma patients. 26634205

2015

Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE Inhibition or upregulation of HIF-1α affects breast cancer cell expression of BCRP; AI responsiveness; and expression of cancer stem cell characteristics, partially through BCRP. 24472707

2014

Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE Transcriptional targeting of human liver carboxylesterase (hCE1m6) and simultaneous expression of anti-BCRP shRNA enhances sensitivity of breast cancer cells to CPT-11. 25368234

2014

Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE Among the membrane efflux transporters of MTX, the human breast cancer resistant protein is the second member of the G subfamily of ATP-binding cassette (ABC) efflux pump (ABCG2). 24718721

2014

Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE CD147 mediates chemoresistance in breast cancer via ABCG2 by affecting its cellular localization and dimerization. 23623923

2013

Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE We have shown, for the first time, that ABCC1, ABCC11, and ABCG2 are highly expressed in aggressive breast cancer subtypes, and that tumor ABCC11 expression is associated with poor prognosis. 23288347

2013

Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE These results suggest that PROG reverses BCRP-mediated MDR by down-regulating BCRP expression in breast cancer cells by affecting transcription from the PRE-containing BCRP promoter. 23988382

2013

Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE Fulvestrant resistance was associated with repression of GPER and the overexpression of CDK6, whereas ERBB2, ABCG2, ER and ER-related genes (GREB1, RERG) or genes expressed in resistant breast cancer (BCAR1, BCAR3) did not contribute to resistance. 24169358

2013

Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE PRL dose-dependently induced ABCG2 expression in T-47D human breast cancer cells. 23150485

2013

Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE Microarray analysis was performed to determine the differential expression patterns of miRNAs that target BCRP between the MX-resistant breast cancer cell line MCF-7/MX and its parental MX-sensitive cell line MCF-7. 23780685

2013

Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE Discovering a novel compound that can suppress ABCG2 expression and restore drug sensitivity could be the key to improving breast cancer therapeutics. 22360613

2012

Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE Our results demonstrated that active PR inactived BCRP expression via progesterone-PR complexes binding to PRE in BCRP promoter in breast cancer cells. 22348324

2012

Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE In conclusion, IL-1β and TNF-α induced ABCG2 and PXR expression and NF-κB activity in some breast cancer and normal cell lines. 22750628

2012

Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE Using the MTT assay, we found that zafirlukast enhanced the cytotoxicity of several anticancer drugs that are substrates of breast cancer resistance proteins (BCRP/ABCG2), including mitoxantrone and SN-38. 22614107

2012

Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE The delivery concept of multiple siRNAs against ABC transporter genes is highly promising for preclinical and clinical investigation in reversing the multidrug resistance phenotype of breast cancer. 22701315

2012

Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE In this study, we aimed to evaluate any positive correlation between COX-2 and ABCG2 gene expression using the COX-2 inducer 12-O-tetradecanoylphorbol-13-acetate (TPA) in human breast cancer cell lines. 22938493

2012

Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE In in vitro selected doxorubicin resistant MCF-7 cells (MCF-7/doxoR) overexpressing the multidrug resistance (MDR) related ABCG2 transporter, we observed a significant HuR downregulation that was paralleled by a corresponding downregulation of HuR targets and by loss of rottlerin toxicity. 22436134

2012

Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE Adenovirus adenine nucleotide translocator-2 shRNA effectively induces apoptosis and enhances chemosensitivity by the down-regulation of ABCG2 in breast cancer stem-like cells. 22198296

2012

Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE Correlation between PXR and ABCG2 patterns of mRNA expression in a MCF7 breast carcinoma cell derivative upon induction by proinflammatory cytokines. 20846001

2011

Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 Biomarker BEFREE Dicer-overexpressing breast cancer cells enriched for cells with enhanced BCRP function. 21878538

2011

Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 AlteredExpression BEFREE For example, the expression of breast cancer-resistant protein (BCRP/ABCG2) has been shown to confer acquired resistance of wild-type EGFR (wtEGFR)-expressing cancer cells to gefitinib. 21487020

2011

Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.400 GeneticVariation BEFREE Genetic polymorphisms of human ABC-transporter genes have been suggested to modulate breast cancer risk in the general population. 21655989

2011