Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 978
Gene Symbol: CDA
CDA
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.310 Therapeutic CTD_human Combined chemotherapy of murine mammary tumors by local activation of the prodrugs ifosfamide and 5-fluorocytosine. 10811482

2000

Entrez Id: 978
Gene Symbol: CDA
CDA
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.310 Biomarker CTD_human Combined chemotherapy of murine mammary tumors by local activation of the prodrugs ifosfamide and 5-fluorocytosine. 10811482

2000

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 Therapeutic CTD_human HER-2/neu is expressed in human renal cell carcinoma at heterogeneous levels independently of tumor grading and staging and can be recognized by HLA-A2.1-restricted cytotoxic T lymphocytes. 10897039

2000

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 Biomarker CTD_human HER-2/neu is expressed in human renal cell carcinoma at heterogeneous levels independently of tumor grading and staging and can be recognized by HLA-A2.1-restricted cytotoxic T lymphocytes. 10897039

2000

Entrez Id: 9429
Gene Symbol: ABCG2
ABCG2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker CTD_human BCRP/MXR/ABCP expression in topotecan-resistant human breast carcinoma cells. 10930538

2000

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 Therapeutic CTD_human Increased ErbB-2 tyrosine kinase activity, MAPK phosphorylation, and cell proliferation in the prostate cancer cell line LNCaP following treatment by select pesticides. 11222871

2001

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 Biomarker CTD_human Increased ErbB-2 tyrosine kinase activity, MAPK phosphorylation, and cell proliferation in the prostate cancer cell line LNCaP following treatment by select pesticides. 11222871

2001

Entrez Id: 374
Gene Symbol: AREG
AREG
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.340 Therapeutic CTD_human Amphiregulin is a vitamin D3 target gene in squamous cell and breast carcinoma. 11237771

2001

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 Biomarker CTD_human Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. 11248153

2001

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 Therapeutic CTD_human Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. 11248153

2001

Entrez Id: 1437
Gene Symbol: CSF2
CSF2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.350 Therapeutic CTD_human Cyclophosphamide, doxorubicin, and paclitaxel enhance the antitumor immune response of granulocyte/macrophage-colony stimulating factor-secreting whole-cell vaccines in HER-2/neu tolerized mice. 11325840

2001

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 Therapeutic CTD_human HER-2 and topo-isomerase IIalpha as predictive markers in a population of node-positive breast cancer patients randomly treated with adjuvant CMF or epirubicin plus cyclophosphamide. 11583189

2001

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 Biomarker CTD_human HER-2 and topo-isomerase IIalpha as predictive markers in a population of node-positive breast cancer patients randomly treated with adjuvant CMF or epirubicin plus cyclophosphamide. 11583189

2001

Entrez Id: 7153
Gene Symbol: TOP2A
TOP2A
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker CTD_human HER-2 and topo-isomerase IIalpha as predictive markers in a population of node-positive breast cancer patients randomly treated with adjuvant CMF or epirubicin plus cyclophosphamide. 11583189

2001

Entrez Id: 540
Gene Symbol: ATP7B
ATP7B
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.300 Biomarker CTD_human Copper-transporting P-type adenosine triphosphatase (ATP7B) is expressed in human breast carcinoma. 11802810

2002

Entrez Id: 1588
Gene Symbol: CYP19A1
CYP19A1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.400 Biomarker CTD_human The major promoter usage for aromatase expression in breast tumors (i.e. cAMP-stimulated promoters I.3 and II) is different from that in normal breast tissue (i.e. glucocorticoid-stimulated promoter I.4). 11850205

2001

Entrez Id: 6591
Gene Symbol: SNAI2
SNAI2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.380 Biomarker CTD_human Modulation of aromatase expression in human breast tissue. 11850205

2001

Entrez Id: 6615
Gene Symbol: SNAI1
SNAI1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.370 Biomarker CTD_human Modulation of aromatase expression in human breast tissue. 11850205

2001

Entrez Id: 7025
Gene Symbol: NR2F1
NR2F1
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.320 Biomarker CTD_human Modulation of aromatase expression in human breast tissue. 11850205

2001

Entrez Id: 2063
Gene Symbol: NR2F6
NR2F6
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.300 Biomarker CTD_human Modulation of aromatase expression in human breast tissue. 11850205

2001

Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 Biomarker CTD_human Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations. 11967536

2002

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 Therapeutic CTD_human Combining the anti-HER2 antibody trastuzumab with taxanes in breast cancer: results and trial considerations. 11970740

2001

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 Biomarker CTD_human Combining the anti-HER2 antibody trastuzumab with taxanes in breast cancer: results and trial considerations. 11970740

2001

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 Biomarker CTD_human HER-2 amplification and topoisomerase IIalpha gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracycline-based therapy or with cyclophosphamide, methotrexate, and 5-fluorouracil. 12006526

2002

Entrez Id: 2064
Gene Symbol: ERBB2
ERBB2
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.500 Therapeutic CTD_human HER-2 amplification and topoisomerase IIalpha gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracycline-based therapy or with cyclophosphamide, methotrexate, and 5-fluorouracil. 12006526

2002