×
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
Breast Carcinoma
0.700
Biomarker
CTD_human
Structural and thermodynamic consequences of the replacement of zinc with environmental metals on estrogen receptor α-DNA interactions.
22038807 2012
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Breast Carcinoma
0.700
Biomarker
CTD_human
To investigate the predictive value of breast cancer susceptibility gene 1 (BRCA1 ) and class IIIβ-tubulin protein expression in tumor tissue for the efficacy of taxol and cisplatin combined chemotherapy (TP) in stage IIIB/IV non-small cell lung cancer (NSCLC) patients.
21781528 2011
×
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
Breast Carcinoma
0.700
Biomarker
CTD_human
ESR-1 gene overexpression happens frequently in breast cancer , but only a subset of them are high amplified cases correlated to increased response rates in hormonal therapy (tamoxifen).20458558 2011
×
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
Breast Carcinoma
0.700
Biomarker
CTD_human
ESR1 amplification as detected by MLPA is rare in breast cancer , and seems to be associated with high ERα expression, high age, high grade and high proliferation.21541733 2011
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Breast Carcinoma
0.700
Biomarker
CTD_human
Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies.
21633166 2011
×
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
Breast Carcinoma
0.700
Biomarker
CTD_human
Correlation of microarray-based breast cancer molecular subtypes and clinical outcomes: implications for treatment optimization.
21501481 2011
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Breast Carcinoma
0.700
Biomarker
CTD_human
Immunophenotypic predictive profiling of BRCA1 -associated breast cancer .
20941507 2011
×
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
Breast Carcinoma
0.700
Biomarker
CTD_human
The Possible Impact of Obesity on Androgen, Progesterone and Estrogen Receptors (ERα and ERβ) Gene Expression in Breast Cancer Patients.
22174584 2011
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Breast Carcinoma
0.700
Biomarker
CTD_human
PI3K pathway activation in breast cancer is associated with the basal-like phenotype and cancer-specific mortality.
19685490 2010
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Breast Carcinoma
0.700
Biomarker
CTD_human
In univariate analysis, PI3K pathway aberrations were associated with death from breast cancer ; however, this relationship was not maintained in multivariate analysis.
19685490 2010
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Breast Carcinoma
0.700
Biomarker
CTD_human
These findings could have important implications for the treatment of PIK3CA -mutant BC s and the development of PI3K /mTOR inhibitors.
20479250 2010
×
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
Breast Carcinoma
0.700
Biomarker
CTD_human
The novel estrogen receptor -alpha (ER-alpha) variant ER-alpha36 is reported to be functional in the estrogen signaling pathway and is related to tamoxifen resistance in breast cancer .
20104649 2010
×
Entrez Id: 675
Gene Symbol: BRCA2
BRCA2
Breast Carcinoma
0.700
Biomarker
CTD_human
Adjuvant systemic therapy for breast cancer in BRCA1/BRCA2 mutation carriers in a population-based study of risk of contralateral breast cancer .
20135344 2010
×
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
Breast Carcinoma
0.700
Biomarker
CTD_human
ESR1 amplification as detected by MLPA is rare in breast cancer , and seems to be associated with high ERα expression, high age, high grade and high proliferation.20966540 2010
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Breast Carcinoma
0.700
Biomarker
CTD_human
Subtle variations in Pten dose determine cancer susceptibility.
20400965 2010
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Breast Carcinoma
0.700
Biomarker
CTD_human
Synchronous bilateral breast carcinoma in a patient with cowden syndrome: a case report with morphologic, immunohistochemical and genetic analysis.
19968660 2010
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Breast Carcinoma
0.700
Biomarker
CTD_human
Adjuvant systemic therapy for breast cancer in BRCA1 /BRCA2 mutation carriers in a population-based study of risk of contralateral breast cancer .
20135344 2010
×
Entrez Id: 207
Gene Symbol: AKT1
AKT1
Breast Carcinoma
0.700
Biomarker
CTD_human
These results suggest that subcellular localization of activated AKT plays a significant role in determining its function in breast cancer , which in part is dependent on TCL1B expression.
20228224 2010
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Breast Carcinoma
0.700
Biomarker
CTD_human
Knockin of mutant PIK3CA activates multiple oncogenic pathways.
19196980 2009
×
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
Breast Carcinoma
0.700
Biomarker
CTD_human
Here, we have sequenced 38 breast cancer cell lines for mutations in the CHEK2 gene and identified two cell lines with deleterious CHEK2 mutations.
18297428 2009
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
Breast Carcinoma
0.700
Biomarker
CTD_human
Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.
18066063 2008
×
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
Breast Carcinoma
0.700
Biomarker
CTD_human
Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.
18066063 2008
×
Entrez Id: 841
Gene Symbol: CASP8
CASP8
Breast Carcinoma
0.700
Biomarker
CTD_human
A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers.
17450141 2007
×
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
Breast Carcinoma
0.700
Biomarker
CTD_human
A subsequent tissue microarray analysis of more than 2,000 clinical breast cancer samples showed ESR1 amplification in 20.6% of breast cancers.
17417639 2007
×
Entrez Id: 841
Gene Symbol: CASP8
CASP8
Breast Carcinoma
0.700
Biomarker
CTD_human
We found evidence of an association with breast cancer for CASP8 D302H (with odds ratios (OR) of 0.89 (95% confidence interval (c.i.): 0.85-0.94) and 0.74 (95% c.i.
17293864 2007