Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 25828
Gene Symbol: TXN2
TXN2
CUI: C0740279
Disease: Cerebellar atrophy
Cerebellar atrophy 		0.100 Biomarker HPO

Entrez Id: 25828
Gene Symbol: TXN2
TXN2
CUI: C0852413
Disease: Abnormal muscle tone
Abnormal muscle tone 		0.100 Biomarker HPO

Entrez Id: 25828
Gene Symbol: TXN2
TXN2
CUI: C1167918
Disease: Increased CSF lactate
Increased CSF lactate 		0.100 Biomarker HPO

Entrez Id: 25828
Gene Symbol: TXN2
TXN2
CUI: C1277241
Disease: Delayed myelination
Delayed myelination 		0.100 Biomarker HPO

Entrez Id: 25828
Gene Symbol: TXN2
TXN2
CUI: C1806780
Disease: Increased CSF protein
Increased CSF protein 		0.100 Biomarker HPO

Entrez Id: 25828
Gene Symbol: TXN2
TXN2
CUI: C1833431
Disease: Subependymal cysts
Subependymal cysts 		0.100 Biomarker HPO

Entrez Id: 25828
Gene Symbol: TXN2
TXN2
CUI: C1836440
Disease: Increased serum lactate
Increased serum lactate 		0.100 Biomarker HPO

Entrez Id: 25828
Gene Symbol: TXN2
TXN2
CUI: C1836923
Disease: Gastrointestinal dysmotility
Gastrointestinal dysmotility 		0.100 Biomarker HPO

Entrez Id: 25828
Gene Symbol: TXN2
TXN2
CUI: C1837397
Disease: Severe global developmental delay
Severe global developmental delay 		0.100 Biomarker HPO

Entrez Id: 25828
Gene Symbol: TXN2
TXN2
CUI: C1837496
Disease: Axonal degeneration
Axonal degeneration 		0.100 Biomarker HPO

Entrez Id: 25828
Gene Symbol: TXN2
TXN2
CUI: C1854699
Disease: Diffuse cerebellar atrophy
Diffuse cerebellar atrophy 		0.100 Biomarker HPO

Entrez Id: 25828
Gene Symbol: TXN2
TXN2
CUI: C1858120
Disease: Generalized hypotonia
Generalized hypotonia 		0.100 Biomarker HPO

Entrez Id: 25828
Gene Symbol: TXN2
TXN2
CUI: C1962966
Disease: Retinopathy, CTCAE
Retinopathy, CTCAE 		0.100 Biomarker HPO

Entrez Id: 25828
Gene Symbol: TXN2
TXN2
CUI: C2677180
Disease: Congenital microcephaly
Congenital microcephaly 		0.100 Biomarker HPO

Entrez Id: 25828
Gene Symbol: TXN2
TXN2
CUI: C2677650
Disease: Decreased activity of mitochondrial complex I
Decreased activity of mitochondrial complex I 		0.100 Biomarker HPO

Entrez Id: 25828
Gene Symbol: TXN2
TXN2
CUI: C3149083
Disease: Decreased activity of mitochondrial complex III
Decreased activity of mitochondrial complex III 		0.100 Biomarker HPO

Entrez Id: 25828
Gene Symbol: TXN2
TXN2
CUI: C3806442
Disease: Myoclonic spasms
Myoclonic spasms 		0.100 Biomarker HPO

Entrez Id: 25828
Gene Symbol: TXN2
TXN2
CUI: C4021758
Disease: Delayed CNS myelination
Delayed CNS myelination 		0.100 Biomarker HPO

Entrez Id: 25828
Gene Symbol: TXN2
TXN2
CUI: C4280681
Disease: Gastrojejunal tube feeding in infancy
Gastrojejunal tube feeding in infancy 		0.100 Biomarker HPO

Entrez Id: 25828
Gene Symbol: TXN2
TXN2
CUI: C4553743
Disease: Spasticity, CTCAE
Spasticity, CTCAE 		0.100 Biomarker HPO

Entrez Id: 25828
Gene Symbol: TXN2
TXN2
CUI: C4721453
Disease: Peripheral Nervous System Diseases
Peripheral Nervous System Diseases 		0.100 Biomarker HPO

Entrez Id: 25828
Gene Symbol: TXN2
TXN2
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.020 Biomarker BEFREE Human liver carcinoma HepG2 cells were exposed to hypoxia/reoxygenation and transfected with TRX2 siRNA. 29569721

2018
Entrez Id: 25828
Gene Symbol: TXN2
TXN2
CUI: C0011847
Disease: Diabetes
Diabetes 		0.020 Biomarker BEFREE Some of the deregulated proteins such as thioredoxin 2, glutathione S transferase, T complex protein 1 subunit β (tcbp1), heat shock protein 90 and E3 ubiquitin ligase were previously reported to be associated with either diabetes or insulin resistance. 28926063

2017
Entrez Id: 25828
Gene Symbol: TXN2
TXN2
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.020 Biomarker BEFREE Some of the deregulated proteins such as thioredoxin 2, glutathione S transferase, T complex protein 1 subunit β (tcbp1), heat shock protein 90 and E3 ubiquitin ligase were previously reported to be associated with either diabetes or insulin resistance. 28926063

2017
Entrez Id: 25828
Gene Symbol: TXN2
TXN2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.020 AlteredExpression BEFREE Hypoxia inhibits expression and function of mitochondrial thioredoxin 2 to promote pulmonary hypertension. 28130258

2017