Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.060 Biomarker BEFREE LDD is closely associated in occurrence and severity with occupational, environmental risk factors and susceptibility genes namely MMP-3, and VDR (ApaI). 23975061

2014

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.060 GeneticVariation BEFREE We investigated the association between vitamin-D receptor gene and estrogen receptor gene polymorphisms and lumbar disc disease in young adults. 12429765

2002

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.060 GeneticVariation BEFREE Based on our results, VDR and its gene variants are highly associated with specific degenerative LDD endophenotypes. 31768839

2020

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.060 AlteredExpression BEFREE Plasma VDR levels and VDR expression were significantly lower in patients with LDD compared with controls (all P < 0.05). 31127184

2019

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.060 GeneticVariation BEFREE There was no evidence that the VDR gene polymorphisms (TaqI, FokI, ApaI) had significant associations with LDD risk. 27613009

2017

Entrez Id: 1638
Gene Symbol: DCT
DCT
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.040 GeneticVariation BEFREE A case-control study of the Trp2/3 alleles of COL9A2/3 genes and their correlation with occurrence of Lumbar disc disease (DDD) as phenotyped by magnetic resonance imaging. 27798555

2016

Entrez Id: 1638
Gene Symbol: DCT
DCT
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.040 Biomarker BEFREE Unlike observations in the Finnish population, Trp2 was common in Japanese, and no association with LDD was apparent. 17024315

2006

Entrez Id: 7218
Gene Symbol: TRP-AGG2-6
TRP-AGG2-6
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.040 GeneticVariation BEFREE In contrast, the Trp2 mutation seems not to be a major susceptibility factor for LDD in a German population. 18080148

2008

Entrez Id: 5903
Gene Symbol: RANBP2
RANBP2
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.040 Biomarker BEFREE Unlike observations in the Finnish population, Trp2 was common in Japanese, and no association with LDD was apparent. 17024315

2006

Entrez Id: 7218
Gene Symbol: TRP-AGG2-6
TRP-AGG2-6
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.040 GeneticVariation BEFREE A case-control study of the Trp2/3 alleles of COL9A2/3 genes and their correlation with occurrence of Lumbar disc disease (DDD) as phenotyped by magnetic resonance imaging. 27798555

2016

Entrez Id: 1638
Gene Symbol: DCT
DCT
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.040 GeneticVariation BEFREE Recently associations of COL9A2 (Trp2 allele) and COL9A3 (Trp3 allele) polymorphisms with lumbar disc disease characterized by sciatica have been reported. 16133074

2006

Entrez Id: 5903
Gene Symbol: RANBP2
RANBP2
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.040 GeneticVariation BEFREE A case-control study of the Trp2/3 alleles of COL9A2/3 genes and their correlation with occurrence of Lumbar disc disease (DDD) as phenotyped by magnetic resonance imaging. 27798555

2016

Entrez Id: 5903
Gene Symbol: RANBP2
RANBP2
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.040 GeneticVariation BEFREE In contrast, the Trp2 mutation seems not to be a major susceptibility factor for LDD in a German population. 18080148

2008

Entrez Id: 1638
Gene Symbol: DCT
DCT
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.040 GeneticVariation BEFREE In contrast, the Trp2 mutation seems not to be a major susceptibility factor for LDD in a German population. 18080148

2008

Entrez Id: 5903
Gene Symbol: RANBP2
RANBP2
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.040 GeneticVariation BEFREE Recently associations of COL9A2 (Trp2 allele) and COL9A3 (Trp3 allele) polymorphisms with lumbar disc disease characterized by sciatica have been reported. 16133074

2006

Entrez Id: 7218
Gene Symbol: TRP-AGG2-6
TRP-AGG2-6
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.040 GeneticVariation BEFREE Recently associations of COL9A2 (Trp2 allele) and COL9A3 (Trp3 allele) polymorphisms with lumbar disc disease characterized by sciatica have been reported. 16133074

2006

Entrez Id: 7218
Gene Symbol: TRP-AGG2-6
TRP-AGG2-6
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.040 Biomarker BEFREE Unlike observations in the Finnish population, Trp2 was common in Japanese, and no association with LDD was apparent. 17024315

2006

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.020 GeneticVariation BEFREE These findings suggest that MMP-2 -1306C/T polymorphism may be a genetic risk factor related to LDD susceptibility in the young adult population. 17680282

2007

Entrez Id: 4314
Gene Symbol: MMP3
MMP3
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.020 GeneticVariation BEFREE We conclude that the CILP gene polymorphism (rs2073711) is associated with a lower risk of LDD, the MMP3 (rs591058) gene polymorphism is associated with LDD among women, and the TT genotype confers a lower risk of LDD. 30288688

2018

Entrez Id: 8743
Gene Symbol: TNFSF10
TNFSF10
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.020 GeneticVariation BEFREE The aim of this study was to determine whether the 1595C/T polymorphism of the TRAIL gene is associated with the increased risk and severity of LDD in the Chinese Han population. 26083528

2015

Entrez Id: 8200
Gene Symbol: GDF5
GDF5
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.020 GeneticVariation BEFREE The association between growth differentiation factor 5 (<i>GDF5</i>), single nucleotide polymorphism (SNP) rs143383 and lumbar disc degeneration (LDD) was investigated. 30186416

2018

Entrez Id: 7219
Gene Symbol: TRP-TGG3-1
TRP-TGG3-1
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.020 Biomarker BEFREE MRI Phenotyping of COL9A2/Trp2 and COL9A3/Trp3 Alleles in Lumbar Disc Disease: A Case-control Study in South-Western Iranian Population Reveals a Significant Trp3-Disease Association in Males. 27798555

2016

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.020 GeneticVariation BEFREE The -735 C/T polymorphism of MMP2 may be associated with the risk and severity of LDD in the Chinese Han population. 23852912

2013

Entrez Id: 842
Gene Symbol: CASP9
CASP9
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.020 GeneticVariation BEFREE Caspase 9 gene polymorphism and susceptibility to lumbar disc disease in the Han population in northern China. 21117896

2011

Entrez Id: 7222
Gene Symbol: TRPC3
TRPC3
CUI: C0221775
Disease: Lumbar disc disease
Lumbar disc disease
0.020 GeneticVariation BEFREE Recently associations of COL9A2 (Trp2 allele) and COL9A3 (Trp3 allele) polymorphisms with lumbar disc disease characterized by sciatica have been reported. 16133074

2006