Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE Here, we assessed whether TGF-β1 affects the ability of HASM cells to relax in response to β<sub>2</sub>-agonists, a mainstay treatment for airway hyperresponsiveness in asthma. 30742476

2019

Entrez Id: 3567
Gene Symbol: IL5
IL5
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE The IL-5 in sputum supernatant was significantly decreased in stable COPD patients with positive BD tests as compared with the patients with asthma (12.5±7.8 vs. 48.2±26.0 ng/mL;.P<0.01). 31346991

2019

Entrez Id: 3567
Gene Symbol: IL5
IL5
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE Eosinophilic COPD may represent an overlap with asthma but the mechanism of eosinophilia is uncertain as, although an increase in sputum IL-5 has been detected, anti-IL-5 therapies are not effective in preventing exacerbations. 30834543

2019

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE Combined administration of anti-IL-13 and anti-IL-17A at individually sub-therapeutic doses limits asthma-like symptoms in a mouse model of Th2/Th17 high asthma. 30353972

2019

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE With the evolution of novel biological therapies, patients, who do not-respond to conventional asthma therapy require novel biologic medications, such as anti-IgE, anti-IL-5 and anti-IL4/IL13 to control asthma symptoms. 31703832

2019

Entrez Id: 3567
Gene Symbol: IL5
IL5
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE In EGPA, although maintenance treatment with the interleukin-5 antagonist mepolizumab is effective in decreasing glucocorticoid requirements and in alleviating asthma and sinonasal symptoms, its efficacy on the vasculitis remains somewhat unclear. 30201478

2019

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE Dupilumab (a monoclonal antibody blocking the shared receptor component for IL-4 and IL-13) is approved for inadequately controlled moderate-to-severe AD and for moderate-to-severe eosinophilic or oral corticosteroid-dependent asthma. 31066001

2019

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression BEFREE EBC and serum ezrin levels correlated with lung function in patients with asthma and serum ezrin levels were negatively correlated with serum IL-13 and periostin. 30290132

2019

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE Asthma is a chronic inflammatory airway disease associated with type 2 cytokines interleukin-4 (IL-4), IL-5, and IL-13, which promote airway eosinophilia, mucus overproduction, bronchial hyperresponsiveness (BHR), and immunogloubulin E (IgE) synthesis. 30995510

2019

Entrez Id: 3567
Gene Symbol: IL5
IL5
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression BEFREE ST2<sup>+</sup> memory CD4<sup>+</sup> T cells have the capacity to produce high levels of IL-5 and Amphiregulin and are involved in the pathology of asthma. 30972065

2019

Entrez Id: 3567
Gene Symbol: IL5
IL5
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE Although these pathognomonic features are mainly mediated by antigen-specific Th2 cells and their cytokines, such as IL-4, IL-5, and IL-13, recent studies have revealed that other inflammatory cells, including Th17 cells and innate lymphoid cells (ILCs), also play a critical role in the pathogenesis of asthma. 30424940

2019

Entrez Id: 3567
Gene Symbol: IL5
IL5
CUI: C0004096
Disease: Asthma
Asthma
0.700 GeneticVariation GWASCAT Moderate-to-severe asthma in individuals of European ancestry: a genome-wide association study. 30552067

2019

Entrez Id: 3567
Gene Symbol: IL5
IL5
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE The administration of anti-IL-5 or anti-IL-5 receptor (IL-5R) antibodies has been shown to reduce eosinophil counts and ameliorate asthmatic symptoms in studies on animal models of allergy as well as in human clinical trials. 29269115

2019

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE Finally, the most potent compounds were found to be metabolically labile, which makes them ideal scaffolds for further development as topical agents for IL-13 mediated diseases of the lungs and skin (for example asthma and atopic dermatitis, respectively). 30981576

2019

Entrez Id: 3567
Gene Symbol: IL5
IL5
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE In addition to anti-IgE therapy that has improved outcomes in allergic asthma for more than a decade, three anti-IL-5 biologics and one anti-IL-4R biologic have recently emerged as promising treatments for T2 asthma. 30525902

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression BEFREE Among elderly asthmatics, subjects with severe asthma had lower FEV1 (% predicted) value, but showed significantly higher serum levels of eotaxin-2 and TGF-β1, than those with non-severe asthma (<i>P</i> < 0.05 for each). 30479079

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE Taken together, the present results have revealed that PCA inhibits asthma airway remodeling by suppressing proliferation and extracellular matrix (ECM) protein deposition in TGF-β1-mediated ASMCs via the inactivation of Smad2/3 signaling pathway. 30472056

2019

Entrez Id: 3567
Gene Symbol: IL5
IL5
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE Anti-IL-5 in Mild Asthma Alters Rhinovirus-induced Macrophage, B-Cell, and Neutrophil Responses (MATERIAL). A Placebo-controlled, Double-Blind Study. 30192638

2019

Entrez Id: 6356
Gene Symbol: CCL11
CCL11
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression BEFREE Eosinophil chemokines eotaxin-1 and eotaxin-2 were significantly upregulated (false discovery rate [FDR] < 0.05) by approximately 2.1- and 1.4-fold in the asthma study and by 2.3- and 1.7-fold in the COPD study following benralizumab treatment. 30658649

2019

Entrez Id: 3567
Gene Symbol: IL5
IL5
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression BEFREE We assessed the effect of placenta-derived MSCs on T cell immune responses and cytokine IL-5 levels according to cultures in children with and without asthma. 31673233

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE MicroRNA-744 Inhibits Proliferation of Bronchial Epithelial Cells by Regulating Smad3 Pathway via Targeting Transforming Growth Factor-β1 (TGF-β1) in Severe Asthma. 30903795

2019

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression BEFREE Our data suggest that hsa_circ_0005519 may induce IL-13 and IL-6 expression by regulating hsa-let-7a-5p in CD4<sup>+</sup> T cells to affect asthma. 31148290

2019

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE <b>Aim:</b> IL-13 is a biomarker of type 2 inflammation that plays a critical role in asthma. 31251105

2019

Entrez Id: 3567
Gene Symbol: IL5
IL5
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE In an ovalbumin (OVA)-induced asthmatic model, inhaled MHF showed significant suppression of airway hyperresponsiveness; a decrease in eosinophil and neutrophil counts, IL-4, IL-5 and leukotriene D<sub>4</sub> in bronchoalveolar lavage fluid; a reduction in total IgE and OVA-specific IgE levels in serum; and suppression of eosinophil infiltration in lung tissue after antigen challenge. 30707957

2019

Entrez Id: 3596
Gene Symbol: IL13
IL13
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE Ovalbumin induces natural killer cells to secrete Th2 cytokines IL‑5 and IL‑13 in a mouse model of asthma. 30816463

2019