×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Neoplastic Syndromes, Hereditary
0.170
CausalMutation
CLINVAR
Penetrance of adrenocortical tumours associated with the germline TP53 R337H mutation.
16033918 2006
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Neoplastic Syndromes, Hereditary
0.170
CausalMutation
CLINVAR
A constitutional de novo mutation in exon 8 of the p53 gene in a patient with multiple primary malignancies.
8688334 1996
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Neoplastic Syndromes, Hereditary
0.170
CausalMutation
CLINVAR
Characterization of the p53 mutants ability to inhibit p73 beta transactivation using a yeast-based functional assay.
12917626 2003
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Neoplastic Syndromes, Hereditary
0.170
GeneticVariation
CLINVAR
A novel TP53 germline inframe deletion identified in a Spanish series of Li-fraumeni syndrome suspected families.
28573494 2017
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Neoplastic Syndromes, Hereditary
0.170
GeneticVariation
CLINVAR
Targeted sequencing of refractory myeloma reveals a high incidence of mutations in CRBN and Ras pathway genes.
27458004 2016
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Neoplastic Syndromes, Hereditary
0.170
CausalMutation
CLINVAR
Transcriptional functionality of germ line p53 mutants influences cancer phenotype.
17606709 2007
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Neoplastic Syndromes, Hereditary
0.170
CausalMutation
CLINVAR
Germ-line splicing mutation of the p53 gene in a cancer-prone family.
1467311 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Neoplastic Syndromes, Hereditary
0.170
GeneticVariation
CLINVAR
The frequency of cancer predisposition gene mutations in hereditary breast and ovarian cancer patients in Taiwan: From BRCA1/2 to multi-gene panels.
28961279 2017
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Neoplastic Syndromes, Hereditary
0.170
CausalMutation
CLINVAR
Germline mutations in BRCA1, BRCA2, CHEK2 and TP53 in patients at high-risk for HBOC: characterizing a Northeast Brazilian Population.
27081505 2014
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Neoplastic Syndromes, Hereditary
0.170
GeneticVariation
CLINVAR
Excessive genomic DNA copy number variation in the Li-Fraumeni cancer predisposition syndrome.
18685109 2008
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Neoplastic Syndromes, Hereditary
0.170
GeneticVariation
CLINVAR
Joint effects of germ-line TP53 mutation, MDM2 SNP309, and gender on cancer risk in family studies of Li-Fraumeni syndrome.
21305319 2011
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Neoplastic Syndromes, Hereditary
0.170
GeneticVariation
CLINVAR
DNA binding cooperativity of p53 modulates the decision between cell-cycle arrest and apoptosis.
20471942 2010
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Neoplastic Syndromes, Hereditary
0.170
CausalMutation
CLINVAR
Germline mutations of p53 but not p16/CDKN2 or PTEN/MMAC1 tumor suppressor genes predispose to gliomas. The ANOCEF Group. Association des NeuroOncologues d'Expression Française.
10589545 1999
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Neoplastic Syndromes, Hereditary
0.170
GeneticVariation
CLINVAR
Germline TP53 variants and susceptibility to osteosarcoma.
25896519 2015
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Neoplastic Syndromes, Hereditary
0.170
GeneticVariation
CLINVAR
Multiple malignancies in a child with de novo TP53 mutation.
21345075 2011
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Neoplastic Syndromes, Hereditary
0.170
GeneticVariation
CLINVAR
Two cases of osteosarcoma occurring as second malignancy of childhood cancer.
10697617 2000
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Neoplastic Syndromes, Hereditary
0.170
CausalMutation
CLINVAR
Heterogeneity in the clinical phenotype of TP53 mutations in breast cancer patients.
11051239 2000
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Neoplastic Syndromes, Hereditary
0.170
CausalMutation
CLINVAR
Characterization of germline TP53 splicing mutations and their genetic and functional analysis.
11420676 2001
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Neoplastic Syndromes, Hereditary
0.170
CausalMutation
CLINVAR
Absence of germline p16(INK4a) alterations in p53 wild type Li-Fraumeni syndrome families.
10922393 2000
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Neoplastic Syndromes, Hereditary
0.170
GeneticVariation
CLINVAR
Identification of a novel germ line variant hotspot mutant p53-R175L in pediatric adrenal cortical carcinoma.
16707427 2006
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Neoplastic Syndromes, Hereditary
0.170
GeneticVariation
CLINVAR
Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy.
10713666 2000
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Neoplastic Syndromes, Hereditary
0.170
GeneticVariation
CLINVAR
Detection of minimal residual cancer to investigate why oral tumors recur despite seemingly adequate treatment.
10914716 2000
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Neoplastic Syndromes, Hereditary
0.170
CausalMutation
CLINVAR
Gastric cancer in individuals with Li-Fraumeni syndrome.
21552135 2011
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Neoplastic Syndromes, Hereditary
0.170
GeneticVariation
CLINVAR
The TP53 mutation, R337H, is associated with Li-Fraumeni and Li-Fraumeni-like syndromes in Brazilian families.
16494995 2007
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
Neoplastic Syndromes, Hereditary
0.170
CausalMutation
CLINVAR
A novel TP53 germline mutation in a family with a history of multiple malignancies: case report and review of the literature.
19127094 2008