|
HLA-DRB1
|
Acute Inflammatory Demyelinating Polyneuropathy
|
0.010 |
Biomarker |
BEFREE |
In AMAN patients, alleles DRB1*1301-03 and DRB1*1312, taken collectively, were increased (19% vs. 0%, P = .009), but by itself, the DRB1*1301 allele was not increased, as in AIDP patients.
|
9396707 |
1997 |
|
HLA-DRB1
|
Acute intermittent porphyria
|
0.030 |
GeneticVariation |
BEFREE |
Although the HLA DRB1*0405-DQB1*0401 haplotype and Fc receptor-like 3 polymorphisms have been associated with AIP, the role of other genetic factors is largely unknown.
|
18341485 |
2008 |
|
HLA-DRB1
|
Acute intermittent porphyria
|
0.030 |
Biomarker |
BEFREE |
The two critical HLA regions for susceptibility to AIP are limited to the HLA-DRB1*0405-DQB1*0401 in the class II and the ABCF1 proximal to C3-2-11, telomeric of HLA-E, in the class I regions.
|
17119950 |
2007 |
|
HLA-DRB1
|
Acute intermittent porphyria
|
0.030 |
GeneticVariation |
BEFREE |
Because HLA-DR*0405 expression fails to protect mice from AIP, the HLA-DRB1*0405 allele appears to be an important risk factor for AIP on the HLA-DRB1*0405/DQB1*0401 haplotype.
|
20303356 |
2010 |
|
HLA-DRB1
|
Acute interstitial pneumonia
|
0.030 |
GeneticVariation |
BEFREE |
Although the HLA DRB1*0405-DQB1*0401 haplotype and Fc receptor-like 3 polymorphisms have been associated with AIP, the role of other genetic factors is largely unknown.
|
18341485 |
2008 |
|
HLA-DRB1
|
Acute interstitial pneumonia
|
0.030 |
Biomarker |
BEFREE |
The two critical HLA regions for susceptibility to AIP are limited to the HLA-DRB1*0405-DQB1*0401 in the class II and the ABCF1 proximal to C3-2-11, telomeric of HLA-E, in the class I regions.
|
17119950 |
2007 |
|
HLA-DRB1
|
Acute interstitial pneumonia
|
0.030 |
GeneticVariation |
BEFREE |
Because HLA-DR*0405 expression fails to protect mice from AIP, the HLA-DRB1*0405 allele appears to be an important risk factor for AIP on the HLA-DRB1*0405/DQB1*0401 haplotype.
|
20303356 |
2010 |
|
HLA-DRB1
|
Acute leukemia
|
0.040 |
AlteredExpression |
BEFREE |
Molecular identification of the HLA-DRB1-DQB1 for diagnosis and follow-up of acute leukemias.
|
20051322 |
2010 |
|
HLA-DRB1
|
Acute leukemia
|
0.040 |
GeneticVariation |
BEFREE |
However, the frequencies of HLA class I (A, B) and class II (DRB1) alleles and haplotypes has not already been determined in Turkish patients with acute leukemia.
|
21820609 |
2011 |
|
HLA-DRB1
|
Acute leukemia
|
0.040 |
GeneticVariation |
BEFREE |
We evaluated the impact of donor-recipient antigenic and allelic HLA-A, -B, -C, and -DRB1 mismatches on mismatched haplotype on outcomes of 509 unmanipulated haplo-HSCTs performed for acute leukemia under a PTCy (N = 313) or ATG (N = 196) regimen.
|
29296709 |
2017 |
|
HLA-DRB1
|
Acute leukemia
|
0.040 |
GeneticVariation |
BEFREE |
We performed the same analysis in a more homogeneous subset of cohort 1 (cohort 2, n = 305) of patients who received transplants for acute leukemia, all given a myeloablative conditioning regimen, and with available allele HLA typing (HLA-A, -B, -C, and -DRB1).
|
27811020 |
2017 |
|
HLA-DRB1
|
Acute lyme disease
|
0.010 |
Biomarker |
BEFREE |
In a comparison of 95 patients with systemic symptoms that persisted after antibiotic treatment for acute Lyme disease (posttreatment chronic Lyme disease) and 104 control subjects without such symptoms after antibiotic treatment, we sought associations between human leukocyte antigen class II (DRB1 and DQB1) markers and posttreatment chronic Lyme disease.
|
16107953 |
2005 |
|
HLA-DRB1
|
Acute lymphocytic leukemia
|
0.070 |
GeneticVariation |
BEFREE |
The frequency of the HLA-DRB1*04 allele was also significantly higher in male patients with ALL and AML, whereas the HLA-DRB1*13 allele was found significantly less frequently in male AML and female ALL patients than in controls.
|
21309500 |
2011 |
|
HLA-DRB1
|
Acute lymphocytic leukemia
|
0.070 |
GeneticVariation |
BEFREE |
We analyzed 3866 recipients in the Japan national registry who underwent their first allogeneic HSCT for acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL) from HLA-A, -B, and -DRB1 allele-genomatched unrelated donors.
|
26456260 |
2016 |
|
HLA-DRB1
|
Acute lymphocytic leukemia
|
0.070 |
Biomarker |
BEFREE |
We report two children with relapsed ALL after HSCT from related donors with HLA-DRB1 and -DQB1 mismatches in the graft versus host direction.
|
26544669 |
2016 |
|
HLA-DRB1
|
Acute lymphocytic leukemia
|
0.070 |
Biomarker |
BEFREE |
HLA-DRB1*07:01-HLA-DQA1*02:01-HLA-DQB1*02:02 haplotype is associated with a high risk of asparaginase hypersensitivity in acute lymphoblastic leukemia.
|
28596278 |
2017 |
|
HLA-DRB1
|
Acute lymphocytic leukemia
|
0.070 |
Biomarker |
BEFREE |
Results showed that the difference between the frequencies of DRB1*13 in patients and normal individuals was significant (p=0.04), but there was a moderate difference among the frequencies of DRB1*04, *07, and *09 in childhood (0-15 years) ALL.
|
18164964 |
2008 |
|
HLA-DRB1
|
Acute lymphocytic leukemia
|
0.070 |
Biomarker |
BEFREE |
We noted a female-specific risk association in childhood ALL (pooled odds ratio (OR) = 2.6, 95% confidence interval (CI) = 1.5-4.5, Mantel-Haenszel P = 0.0009) similar to the stronger association of DRB1*1501 in females with MS.
|
21067287 |
2010 |
|
HLA-DRB1
|
Acute lymphocytic leukemia
|
0.070 |
Biomarker |
BEFREE |
We found A*02 B*39 DRB1*16 haplotype negatively associated with AML, whereas A*02 B*35 DRB1*13 was in ALL (p = 0.015, and p = 0.017; respectively).
|
21820609 |
2011 |
|
HLA-DRB1
|
Acute myocardial infarction
|
0.010 |
GeneticVariation |
BEFREE |
The HLA-DRB1*0101 allele, as well as the HLA-DRB1*0101-DQA1*01-DQB1*05 haplotype, was found to be associated with increased risk for AMI (OR 1.24; 95% CI 1.00-1.54 for both).
|
20141563 |
2010 |
|
HLA-DRB1
|
Acute periodontitis
|
0.010 |
Biomarker |
BEFREE |
Among others, the known positive associations for HLA-A*68/69 (A28) and HLA-DRB1*04 were confirmed by the haplotypes HLA-A*68/69 : Cw*07 : B*18 in aggressive periodontitis (p < 0.05) and HLA-Cw*08 : B*14 : DRB1*04 in chronic periodontitis (p < 0.05).
|
12941076 |
2003 |
|
HLA-DRB1
|
Acute Promyelocytic Leukemia
|
0.010 |
GeneticVariation |
BEFREE |
On the other hand, others are more disease specific (HLA-DRB1*11 for systemic sclerosis and HLA-DRB1 alleles encoding the "shared epitope" in RA) as well as non MHC genes, such as FcyRIIa and IIIa in SLE, the beta2 glycoprotein I gene in the aPL syndrome, and the TSHR gene in Graves' disease).
|
16890892 |
2006 |
|
HLA-DRB1
|
Acute-On-Chronic Liver Failure
|
0.010 |
GeneticVariation |
BEFREE |
Analysis identified <i>HLA-DRB1*12:02</i> as the top susceptible HLA allele associated with ACLF (p=3.94×10<sup>-6</sup>, OR=2.05).
|
28130311 |
2018 |
|
HLA-DRB1
|
Addison Disease
|
0.100 |
Biomarker |
BEFREE |
Genetic factors including HLA-DRB1*0404 and MICA have been associated with AD in populations with and without T1D.
|
19820007 |
2009 |
|
HLA-DRB1
|
Addison Disease
|
0.100 |
GeneticVariation |
BEFREE |
Particularly strong susceptibility for AD was found for the DR3-DQ2/ DRB1*0404-DQ8 genotype (odds ratio, 32; P = 4 x 10(-17)), which predicted early onset.
|
19858318 |
2009 |