Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 Biomarker CTD_human 4-Hydroxy-2(E)-nonenal metabolism differs in Apc(+/+) cells and in Apc(Min/+) cells: it may explain colon cancer promotion by heme iron. 21967605

2011

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 Biomarker CTD_human Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations. 21531761

2011

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 Biomarker CTD_human Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. 21291235

2011

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 Biomarker CTD_human The association of methylation in the promoter of APC and MGMT and the prognosis of Taiwanese CRC patients. 19309276

2009

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 Biomarker CTD_human Epigenetic regulation of WNT signaling pathway genes in inflammatory bowel disease (IBD) associated neoplasia. 18716850

2008

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 Biomarker CTD_human Dietary folate and APC mutations in sporadic colorectal cancer. 17116713

2006

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 Biomarker CTD_human Proteomic analysis of intestinal epithelial cells expressing stabilized beta-catenin. 12907644

2003

Entrez Id: 324
Gene Symbol: APC
APC
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.900 GeneticVariation UNIPROT

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker CTD_human Resveratrol prevents tumorigenesis in mouse model of Kras activated sporadic colorectal cancer by suppressing oncogenic Kras expression. 25280562

2014

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker CTD_human Fluorinated N,N-dialkylaminostilbenes for Wnt pathway inhibition and colon cancer repression. 21291235

2011

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker CTD_human Genomic and epigenomic integration identifies a prognostic signature in colon cancer. 21278247

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker CTD_human A germline variant in the TP53 polyadenylation signal confers cancer susceptibility. 21946351

2011

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker CTD_human The predictive value of p53 and p33(ING1b) in patients with Dukes'C colorectal cancer. 17949449

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker CTD_human K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy. 18676755

2008

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker CTD_human Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis. 18507500

2008

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker CTD_human Functional categories of TP53 mutation in colorectal cancer: results of an International Collaborative Study. 16524972

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker CTD_human Variance in the expression of 5-Fluorouracil pathway genes in colorectal cancer. 15814641

2005

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker CTD_human Determination of TP53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients. 16110022

2005

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker CTD_human p53 is an independent pre-treatment markers for long-term survival in stage II and III colorectal cancers: an analysis of interaction between genetic markers and fluorouracil-based adjuvant therapy. 15172127

2004

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker CTD_human Correlation of Ki-67, p53, and Adnab-9 immunohistochemical staining and ploidy with clinical and histopathologic features of severely dysplastic colorectal adenomas. 12645814

2003

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker CTD_human Proteomic analysis of intestinal epithelial cells expressing stabilized beta-catenin. 12907644

2003

Entrez Id: 1499
Gene Symbol: CTNNB1
CTNNB1
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.700 Biomarker CTD_human More frequent beta-catenin gene mutations in adenomas than in aberrant crypt foci or adenocarcinomas in the large intestines of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-treated rats. 10965019

2000

Entrez Id: 7298
Gene Symbol: TYMS
TYMS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.600 Biomarker CTD_human Highly Expressed Genes in Rapidly Proliferating Tumor Cells as New Targets for Colorectal Cancer Treatment. 25944804

2015

Entrez Id: 7298
Gene Symbol: TYMS
TYMS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.600 Biomarker CTD_human Prognostic significance of numeric aberrations of genes for thymidylate synthase, thymidine phosphorylase and dihydrofolate reductase in colorectal cancer. 18607850

2008

Entrez Id: 7298
Gene Symbol: TYMS
TYMS
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.600 Biomarker CTD_human K-Ras mutations and treatment outcome in colorectal cancer patients receiving exclusive fluoropyrimidine therapy. 18676755

2008