Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.400 GeneticVariation BEFREE IKZF1 Gene Deletion in Pediatric Patients Diagnosed with Acute Lymphoblastic Leukemia in Mexico. 30974435

2019

Entrez Id: 4851
Gene Symbol: NOTCH1
NOTCH1
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.400 Biomarker BEFREE These results support the role of aberrant chromatin accessibility and consequent oncogenic <i>MYC</i> enhancer activation in NOTCH1-induced T-ALL.<i>This article is highlighted in the In This Issue feature, p. 1631</i>. 31519704

2019

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.400 Biomarker BEFREE Inclusion of CDKN2A/B status may further improve the risk stratification of ALL patients. 30592434

2019

Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.400 Biomarker BEFREE An 11-year-old male patient with the deletion of <i>IKZF1</i> (Ikaros family zinc finger 1) and positive Breakpoint Cluster Region-C-Abelson oncogene 1(<i>BCR-ABL1</i>) acute lymphoblastic leukemia developed mucositis, gastrointestinal toxicity, hepatotoxicity, myelosuppression, and severe dermatologic toxicity during the first and second courses of high-dose methotrexate. 31607921

2019

Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.400 GeneticVariation BEFREE IKZF1 Deletions with COBL Breakpoints Are Not Driven by RAG-Mediated Recombination Events in Acute Lymphoblastic Leukemia. 30877974

2019

Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.400 GeneticVariation BEFREE IKZF1 rs4132601 and rs10272724 could be considered significant risk contributors to childhood acute lymphoblastic leukaemia and may impact the iron profiles in these children. 30806315

2019

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.400 GeneticVariation BEFREE Our findings demonstrate a higher penetrance of the CDKN2A risk locus in DS and serve as a basis for further biological insights into DS-ALL etiology. 31350265

2019

Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.400 GeneticVariation BEFREE IKZF1 deletion and co-occurrence with other aberrations in a child with chronic myeloid leukemia progressing to acute lymphoblastic leukemia. 30511400

2019

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.400 Biomarker BEFREE Common CNAs involved CDKN2A/2B (30.3%), IKZF1 (27.3%), PAX5 (9.1%), RB1 (9.1%), BTG1 (6.7%), and ETV6 (6.7%), which regulate cell cycle, B lymphopoiesis, or act as tumor suppressors in ALL. 31112375

2019

Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.400 Biomarker BEFREE Common CNAs involved CDKN2A/2B (30.3%), IKZF1 (27.3%), PAX5 (9.1%), RB1 (9.1%), BTG1 (6.7%), and ETV6 (6.7%), which regulate cell cycle, B lymphopoiesis, or act as tumor suppressors in ALL. 31112375

2019

Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.400 AlteredExpression BEFREE CK2 inhibitor by increasing IKAROS activity significantly suppresses <i>RAG1</i> expression in ALL in an IKAROS-dependent manner. 31333801

2019

Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.400 GeneticVariation BEFREE We demonstrated the association of IKZF1 polymorphism rs4132601 T/G with increased risk of ALL among Tunisian pediatric cohort, with altered phenotypic changes among ALL patients. 31604453

2019

Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.400 Biomarker BEFREE The many faces of IKZF1 in B-cell precursor acute lymphoblastic leukemia. 29519871

2018

Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.400 GeneticVariation BEFREE Our results demonstrate that the IKAROS promotes PHF2 expression, and suggest that PHF2 <sup>low</sup> expression works with the IKAROS gene deletion to drive oncogenesis of ALL. 28994305

2018

Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.400 GeneticVariation BEFREE Prognostic impact of kinase-activating fusions and IKZF1 deletions in pediatric high-risk B-lineage acute lymphoblastic leukemia. 29507076

2018

Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.400 GeneticVariation BEFREE The multiplex ligation-dependent probe amplification (MLPA) method was used to detect the copy number alterations (CNAs) of IKAROS family zinc finger 1 (<i>IKZF1</i>), paired box 5 (<i>PAX5</i>), ETS variant 6 (<i>ETV6</i>), RB transcriptional corepressor 1 (<i>RB1</i>), BTG anti-proliferation factor 1 (<i>BTG1</i>), early B-cell factor 1 (<i>EBF1</i>), cyclin dependent kinase inhibitor 2A/2B (<i>CDKN2A/2B</i>) and cytokine receptor like factor 2 (<i>CRLF2</i>) genes in 87 adults with acute lymphoblastic leukemia (ALL) in China. 29552179

2018

Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.400 GeneticVariation BEFREE Development of a Fluorescence in Situ Hybridization Probe for Detecting IKZF1 Deletion Mutations in Patients with Acute Lymphoblastic Leukemia. 29957452

2018

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.400 Biomarker BEFREE <i>CDKN2A/2B</i> deletions were associated with poor 2-year OS (P=0.045) and RFS (P=0.071) rates in Philadelphia chromosome positive (Ph<sup>+</sup>) B-ALL patients, as well as in the high risk (HR) B-ALL group (P=0.037 and P=0.047, respectively). 29552179

2018

Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.400 Biomarker BEFREE By contrast, the MRD15 was higher in Ikaros family Zinc Finger Protein 1 (<i>IKZF1)</i>-deleted BCP-ALL patients than in BCP-ALL patients without <i>IKZF1</i> deletions [1.18% (0.06-12.0%) vs 0.33% (0.03-2.6%); p=0.003]. 29899835

2018

Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.400 GeneticVariation BEFREE Patients and Methods The analysis involved 991 patients with BCP ALL treated in the Associazione Italiana Ematologia ed Oncologia Pediatrica-Berlin-Frankfurt-Muenster (AIEOP-BFM) ALL 2000 trial with complete information for copy number alterations of IKZF1, PAX5, ETV6, RB1, BTG1, EBF1, CDKN2A, CDKN2B, Xp22.33/Yp11.31 (PAR1 region; CRLF2, CSF2RA, and IL3RA), and ERG; replication of findings involved 417 patients from the same trial. 29498923

2018

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.400 GeneticVariation BEFREE Previous studies involving CDKN2A/B gene deletions have shown mixed associations with survival outcome in childhood ALL. 29446543

2018

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.400 GeneticVariation BEFREE Association of the independent polymorphisms in CDKN2A with susceptibility of acute lymphoblastic leukemia. 29654170

2018

Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.400 Biomarker BEFREE Intensifying Treatment of Childhood B-Lymphoblastic Leukemia With IKZF1 Deletion Reduces Relapse and Improves Overall Survival: Results of Malaysia-Singapore ALL 2010 Study. 30044693

2018

Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.400 GeneticVariation BEFREE In this issue of Cancer Cell, Churchman et al. add to the list of leukemia predisposition genes with the identification and characterization of germline IKZF1 variants in childhood ALL. 29763621

2018

Entrez Id: 10320
Gene Symbol: IKZF1
IKZF1
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia
0.400 GeneticVariation BEFREE These results identify IKZF1 as a leukemia predisposition gene, and emphasize the importance of germline genetic variation in the development of both familial and sporadic ALL. 29681510

2018