Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE Transcriptomic profiling and quantitative high-throughput (qHTS) drug screening of CDH1 deficient hereditary diffuse gastric cancer (HDGC) cells identify treatment leads for familial gastric cancer. 28460635

2018

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 GeneticVariation BEFREE Circulating tumor DNA profiling by next generation sequencing reveals heterogeneity of crizotinib resistance mechanisms in a gastric cancer patient with MET amplification. 28460431

2018

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR. 29443099

2018

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 GeneticVariation BEFREE Up to 10% of cases of gastric cancer are familial, but so far, only mutations in CDH1 have been associated with gastric cancer risk. 28024868

2017

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE This study was conducted to investigate whether human epidermal growth factor receptor 2 (HER2) status, epidermal growth factor receptor (EGFR) status, and c-MET status are independent prognostic factors for advanced gastric cancer patients who received standard chemotherapy. 25682441

2017

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 GeneticVariation BEFREE A prospective gastric cancer database identified 41 patients with CDH1 mutation who underwent total gastrectomy during 2005 to 2015. 27759617

2017

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 AlteredExpression BEFREE Digital PCR identifies changes in CDH1 (E-cadherin) transcription pattern in intestinal-type gastric cancer. 27861150

2017

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 AlteredExpression BEFREE Finally, we observed an inverse correlation between the expression of miR-144 and MET mRNA in GC metastatic tissues. 25927670

2016

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE In this study, we focused on frequencies of EGFR, ErbB2 and MET gene amplification in gastric cancer patients to develop personalized medicine to improve the treatment. 25820598

2016

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE Identification of short-form RON as a novel intrinsic resistance mechanism for anti-MET therapy in MET-positive gastric cancer. 26528757

2016

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE The clinicopathological significance of CDH1 in gastric cancer: a meta-analysis and systematic review. 25926721

2016

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 GeneticVariation BEFREE The updated guidelines include revised CDH1 testing criteria (taking into account first-degree and second-degree relatives): (1) families with two or more patients with gastric cancer at any age, one confirmed DGC; (2) individuals with DGC before the age of 40 and (3) families with diagnoses of both DGC and LBC (one diagnosis before the age of 50). 25979631

2016

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 AlteredExpression BEFREE Epigenetic regulation of CDH1 exon 8 alternative splicing in gastric cancer. 26674321

2016

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 AlteredExpression BEFREE Targeting gastric cancers with amplified or abnormally activated MET may have therapeutic benefit based on nonclinical and emerging clinical findings. 26543351

2016

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE Human cancer cell lines and gastric cancer tissue microarrays were examined for MET amplification by fluorescence in situ hybridization (FISH). 26879245

2016

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE These findings indicate that the miR-1/MET pathway is a potential therapeutic target due to its crucial role in gastric cancer cell proliferation and migration. 25874496

2016

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE We also showed that HOTAIR recruiting and binding to PRC2 epigenetically represses miR34a, which controls the targets C-Met (HGF/C-Met/Snail pathway) and Snail, thus contributing to GC cell-EMT process and accelerating tumor metastasis. 26136075

2016

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE The frequencies of gene amplifications in advanced gastric cancers were as follows: ERBB2 (13 cases, 14%), FGFR2 (7 cases, 8%), MYC (7 cases, 8%), TOP2A (7 cases, 8%), MET (4 cases, 4%), MDM2 (4 cases, 4%), CCND1 (3 cases, 3%), FGF10 (2 cases, 3%), and EGFR (1 case, 1%). 25743022

2016

Entrez Id: 4233
Gene Symbol: MET
MET
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 Biomarker BEFREE Volitinib, a potent and highly selective c-Met inhibitor, effectively blocks c-Met signaling and growth in c-MET amplified gastric cancer patient-derived tumor xenograft models. 25248999

2016

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 AlteredExpression BEFREE CDH1 was downregulated in diffuse-type GC tissues (P=0.0007) and showed a negative relationship with HOTAIR (r(2)=0.154, P=0.0354). 26136075

2016

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 GeneticVariation BEFREE For patients with an identified germline E-cadherin-1 (CDH1) mutation, prophylactic gastrectomy is the treatment of choice to eliminate the high risk of developing diffuse gastric cancer. 26443527

2016

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 AlteredExpression BEFREE Deregulation of ARID1A, CDH1, cMET and PIK3CA and target-related microRNA expression in gastric cancer. 26334097

2016

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 PosttranslationalModification BEFREE Deregulation between miR-29b/c and DNMT3A is associated with epigenetic silencing of the CDH1 gene, affecting cell migration and invasion in gastric cancer. 25874772

2016

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 GeneticVariation BEFREE Lack of association between the CDH1 polymorphism and gastric cancer susceptibility: a meta-analysis. 25599647

2016

Entrez Id: 999
Gene Symbol: CDH1
CDH1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.700 GeneticVariation BEFREE Early-onset diffuse gastric cancer associated with a de novo large genomic deletion of CDH1 gene. 23812922

2015