Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker GENOMICS_ENGLAND Germline PIK3CA and AKT1 mutations in Cowden and Cowden-like syndromes. 23246288

2013

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker CTD_human We measured AKT1 and GSK-3β proteins and phosphorylation in human peripheral blood mononuclear cells, functional MRI cingulate response during attentional control, behavioral accuracy during sustained attention, and response to 8 wk of treatment with olanzapine in a total of 190 healthy subjects and 66 patients with schizophrenia. 21187413

2011

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker CTD_human Our study suggests that AKT1 is a susceptibility gene for schizophrenia in the Chinese population and that the AKT1 gene may play no major role in the therapeutic response to antipsychotics or in chlorpromazine-induced extrapyramidal syndrome. 17915974

2007

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker CTD_human For schizophrenia, positive associations of SNPs and AKT1 haplotypes were reported in US and Japanese samples. 15982448

2006

Entrez Id: 207
Gene Symbol: AKT1
AKT1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.900 Biomarker CTD_human Consistent with this proposal, we also show that haloperidol induces a stepwise increase in regulatory phosphorylation of AKT1 in the brains of treated mice that could compensate for an impaired function of this signaling pathway in schizophrenia. 14745448

2004

Entrez Id: 9863
Gene Symbol: MAGI2
MAGI2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.850 Biomarker CTD_human One of the rare CNVs found in SZ cohorts is the duplication of Synaptic Scaffolding Molecule (S-SCAM, also called MAGI-2), which encodes a postsynaptic scaffolding protein controlling synaptic AMPA receptor levels, and thus the strength of excitatory synaptic transmission. 25653350

2015

Entrez Id: 9863
Gene Symbol: MAGI2
MAGI2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.850 Biomarker PSYGENET One of the rare CNVs found in SZ cohorts is the duplication of Synaptic Scaffolding Molecule (S-SCAM, also called MAGI-2), which encodes a postsynaptic scaffolding protein controlling synaptic AMPA receptor levels, and thus the strength of excitatory synaptic transmission. 25653350

2015

Entrez Id: 9863
Gene Symbol: MAGI2
MAGI2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.850 Biomarker PSYGENET In conclusion, although we could not detect strong genetic evidence for association of common variants in MAGI2 and increased schizophrenia risk in a Japanese population, these SNPs may increase risk of cognitive impairment in schizophrenic patients. 22649501

2012

Entrez Id: 9863
Gene Symbol: MAGI2
MAGI2
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.850 Biomarker PSYGENET Because earlier work had identified a CNV in the close relative MAGI2 in SZ, the study was extended to include MAGI2. 22381734

2012

Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET These results underline the relevance of the risk "A" allele to neurocognitive functioning and suggest that its detrimental effects on cognition, may be part of the mechanism by which the CSMD1 mediates risk for schizophrenia. 24630139

2014

Entrez Id: 1139
Gene Symbol: CHRNA7
CHRNA7
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET The α7 nicotinic acetylcholine receptor gene (CHRNA7) is linked to schizophrenia. 25056953

2014

Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET A post hoc analysis of loci significantly associated with psychiatric disorders suggested that genetic variation at CSMD1, a schizophrenia susceptibility locus, plays a role in the ratio between dopamine and serotonin metabolites in CSF. 23319000

2014

Entrez Id: 6925
Gene Symbol: TCF4
TCF4
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET The analyses on the 28 individual SNPs previously associated with schizophrenia found that two SNPs in TCF4 returned a significant association with the SPEQ Paranoia dimension, rs17512836 (p-value = 2.57×10⁻⁴) and rs9960767 (p-value = 6.23×10⁻⁴). 24718684

2014

Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET In particular, our two-stage strategy found association in both our combined case/control analysis and the family-based analysis on 1q21.2 (closest gene: sphingosine-1-phosphate receptor 1 gene, S1PR1) and on 1q24.1 near the gene TMCO1, and at CSMD1 on 8p23.2, supporting several previous GWAS reports for BD and for schizophrenia. 24387768

2014

Entrez Id: 6925
Gene Symbol: TCF4
TCF4
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET No effect of schizophrenia risk genes MIR137, TCF4, and ZNF804A on macroscopic brain structure. 25217366

2014

Entrez Id: 6925
Gene Symbol: TCF4
TCF4
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET Single nucleotide polymorphisms in TCF4 gene have been consistently associated with schizophrenia in genome wide association studies, including the C allele of rs9960767. 24275585

2014

Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET In accordance with previous evidence, these data suggest that CSMD1 may mediate brain function related to cognitive processes (i.e., executive function); with the relatively deleterious effects of the identified "A" risk allele on brain activity possibly constituting part of the mechanism by which CSMD1 increases schizophrenia risk. 23839771

2013

Entrez Id: 64478
Gene Symbol: CSMD1
CSMD1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET Neuropsychological deficits in mice depleted of the schizophrenia susceptibility gene CSMD1. 24244513

2013

Entrez Id: 6925
Gene Symbol: TCF4
TCF4
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET Genome-wide association studies have also found that common variants in TCF4 are associated with an increased risk of schizophrenia. 24058414

2013

Entrez Id: 1139
Gene Symbol: CHRNA7
CHRNA7
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET The purpose of the current study was to explore the association of auditory P50 sensory gating (P50) and prepulse inhibition (PPI) of schizophrenia with polymorphisms in the CHRNA7 and COMT genes. 23598060

2013

Entrez Id: 63826
Gene Symbol: SRR
SRR
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion. 22801410

2013

Entrez Id: 1139
Gene Symbol: CHRNA7
CHRNA7
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET Two SNPs in CHRNA7 were associated with schizophrenia in African-Americans, and a second SNP in CHRNA7 was significant for an association with smoking and smoking in schizophrenia in Caucasians. 21970977

2012

Entrez Id: 1139
Gene Symbol: CHRNA7
CHRNA7
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker PSYGENET The CHRNA7 gene, which encodes the α7 nicotinic acetylcholine receptor (α7*nAChR), has been implicated as a candidate gene in schizophrenia. 21979958

2011

Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker CTD_human Our findings link NRXN2 disruption to the pathogenesis of ASD for the first time and further strengthen the involvement of NRXN1 in SCZ, supporting the notion of a common genetic mechanism in these disorders. 21424692

2011

Entrez Id: 9378
Gene Symbol: NRXN1
NRXN1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker CTD_human At a gene level, CAM genes associated in all three samples (NRXN1 and CNTNAP2), which were previously implicated in specific language disorder, autism and schizophrenia. 20157312

2011