Source: BEFREE

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia
0.900 Biomarker BEFREE Interferon-γ (IFNγ) has been identified as a common cause of various hematopoietic abnormalities, such as aplastic anemia. 31668371

2020

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia
0.900 Biomarker BEFREE As a negative effector cytokine, interferon gamma (IFNγ) takes part in aplastic anemia through its inhibitory effect on hematopoiesis. 31141802

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia
0.900 Biomarker BEFREE The concentration of interferon-γ and interleukin-17 in the AA group were higher (<i>p</i> = 0.004; <i>p</i> = 0.003), whereas the concentration of <i>TGF-β</i> decreased (<i>p</i> = 0.044). 31287345

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia
0.900 Biomarker BEFREE Interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) have been implicated historically in the immune pathophysiology of aplastic anemia (AA) and other bone marrow (BM) failure syndromes. 30361263

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia
0.900 GeneticVariation BEFREE IFN-γ +874 A/T gene polymorphism is associated with the etiology of AA in Egyptian patients. 26214243

2016

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia
0.900 GeneticVariation BEFREE Polymorphisms in TNF and IFNG are associated with clinical characteristics of aplastic anemia in Argentinean population. 25248876

2015

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia
0.900 Biomarker BEFREE The data suggest that AA occurs when IFN-γ inhibits the generation of myeloid progenitors and prevents lineage differentiation, as opposed to infiltration of activated T cells. 25342713

2014

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia
0.900 AlteredExpression BEFREE Plasma IL-18, IFN-γ and IL-4 levels were measured in patients with newly diagnosed AA (n = 29), AA in remission (n = 22) and healthy subjects (n = 30) via enzyme-linked immunosorbent assay (ELISA). 23334427

2013

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia
0.900 Biomarker BEFREE Eight SNP loci in five cytokine genes, including tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), transforming growth factor-beta (TGF-β), interleukin-6 (IL-6), and IL-10, and aplastic anemia (AA) were assessed. 22800824

2012

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia
0.900 Biomarker BEFREE Interleukin-27 enhances the production of tumour necrosis factor-α and interferon-γ by bone marrow T lymphocytes in aplastic anaemia. 21506940

2011

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia
0.900 GeneticVariation BEFREE Our findings suggest that alterations in KIR/KIR-L matching, such as increased 3DL2 and decreased 2DS1 mismatch, and in the polymorphisms of TGFβ1, IFN-γ, TNF- α and IL-10 may account for the propensity to immunemediated killing of hematopoietic stem cells and/or ineffective hematopoiesis characteristic of AA and MDS. 21561401

2011

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia
0.900 GeneticVariation BEFREE This exploratory study concurred with prior studies indicating that polymorphisms in IFNG are related to AA susceptibility. 20953611

2011

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia
0.900 GeneticVariation BEFREE The results showed that the frequency of IFN-γ +874 TT genotype in patients with aplastic anemia was significantly higher than the corresponding frequency in the healthy adults (42.6% vs. 17.6%, χ(2)=13.78, p=0.01). 20934357

2010

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia
0.900 GeneticVariation BEFREE Blocking the transcription of the IFN-gamma gene with kinase inhibitors might lead to the development of novel therapeutic agents for patients with aplastic anemia and other autoimmune diseases. 16434488

2006

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia
0.900 Biomarker BEFREE Comparison between the IFN-gamma transcriptome in normal CD34 cells and changes previously detected in CD34 cells from AA and PNH patients reveals the presence of many similarities that may reflect molecular signature of in vivo IFN-gamma exposure. 16131564

2006

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia
0.900 GeneticVariation BEFREE Homozygosis for (12) CA repeats in the first intron of the human IFN-gamma gene is significantly associated with the risk of aplastic anaemia in Caucasian population. 15327519

2004

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia
0.900 Biomarker BEFREE T cells from aplastic anemia (AA) patients secrete IFN-gamma in vitro, activated cytotoxic lymphocytes infiltrate aplastic bone marrow (BM), and IFN-gamma mRNA, not detected in normal BM, is present in BM from most AA patients. 8639773

1996

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia
0.900 AlteredExpression BEFREE In contrast, IFN-gamma mRNA was only demonstrable in BMMC from some patients with aplastic anemia, irrespective of a history of transfusions. 1586705

1992

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 AlteredExpression BEFREE These findings suggest that the increased peripheral B:9-23rPep-specific IFN-γ immunoreactivity reflects decreased functional β-cell mass and greater disease activity of type 1 diabetes. 31525445

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 AlteredExpression BEFREE The serum levels of IL-2 and IFN-γ were lower in both groups with T1D compared to controls, whilst the level of IL-4 did not differ. 31560963

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker BEFREE Interferon γ plays a critical role in the pathogenesis of type 1 diabetes. 30827273

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 AlteredExpression BEFREE Similarly, Interferon γ (IFN-γ), and intracellular free Calcium Ion (ifCa2+) levels were increased in T1D MOs than in control MOs, but the difference did not reach a significant level. 31322069

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker BEFREE Through functional analysis of the encoding genes coexpressed by the three lncRNAs, we found these genes were mainly enriched in type 1 diabetes and autoimmune thyroid disease pathways, whereas in Gene Ontology (GO) function classification, they were also mainly enriched in the immune response, type I interferon signaling pathways, interferon-γ mediated signaling pathways, and so forth. 30317603

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker BEFREE The messenger RNA (mRNA) levels and contents of interleukin (IL)-10, IL-4, transforming growth factor (TGF)-β, IL-2, IL-17, and IFN-γ in patients with T1D, healthy volunteers, streptozotocin (STZ)-induced T1D rat model, the control rat, and Treg infusion rats were determined by reverse transcription polymerase chain reaction and the enzyme-linked immunosorbent assay, respectively. 31535398

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
Diabetes Mellitus, Insulin-Dependent
0.600 Biomarker BEFREE Moreover, the ratio of CCR6-CXCR3+ and CCR6+CXCR3- memory Tregs was altered and the frequency of proliferating Ki67-positive and IFN-γ producing memory Tregs was decreased in children with T1D. 30723474

2019