Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.700 Biomarker BEFREE IL-10 knockout (IL-10 KO) mice were used as the human CD models in this study. 31677991

2020

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.700 Biomarker BEFREE The interleukin-10 knockout (IL-10 KO) mouse is a well-known animal model of IBD that develops spontaneous intestinal inflammation resembling Crohns disease. 31158947

2020

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 Biomarker BEFREE These results suggest that IL-10 production by ManLAM-treated B cells contributes to keeping the balance between CD4<sup>+</sup> T cell subsets and protect mice from DSS-induced IBD. 31657484

2020

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 GeneticVariation BEFREE The data suggest that endogenous T cell-derived opioids might reduce inflammation-induced abdominal pain in inflammatory bowel diseases associated with homozygous "loss of function mutations" in interleukin-10. 31588671

2020

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 Biomarker BEFREE The interleukin-10 knockout (IL-10 KO) mouse is a well-known animal model of IBD that develops spontaneous intestinal inflammation resembling Crohns disease. 31158947

2020

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 GeneticVariation BEFREE SNPs rs1800896, rs3024505 (IL-10); rs11209026 (IL23R); rs2066844, rs2066845 (NOD-2), and rs2241880 (ATG16L1) were assessed in 93 patients with IBD and 200 healthy controls by hybridization probes and quantitative PCR. 31651650

2020

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 Biomarker BEFREE These results identify a regulatory interaction between IL-10 and PGE2, dysregulation of which may drive aberrant Mφ activation and impaired host defense contributing to IBD pathogenesis. 31819956

2020

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 AlteredExpression BEFREE Furthermore, a positive correlation was observed between IL-10 serum levels and ocular manifestations in BD patients, in contrast to those of IL-17, showing no correlation with the different clinical manifestations. 31122907

2019

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 GeneticVariation BEFREE This meta-analysis showed that the IL-10 - 819 C/T and - 592 C/A polymorphisms are associated with BD susceptibility, especially in Asian population. 31721090

2019

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 Biomarker BEFREE Treg and Th17 cell frequencies and Th17 RORγt expression were significantly elevated, and IL-10 concentration in Treg cell supernatants was significantly lower in BD patients than in controls. 30601931

2019

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0004943
Disease: Behcet Syndrome
Behcet Syndrome
0.700 Biomarker BEFREE HBV: hepatitis B virus; HCC hepatocellular carcinoma; TNFSF10: tumor necrosis factor superfamily member 10; ATG5: autophagy-related protein 5; DNA: deoxyribonucleic acid; LDR-PCR: ligase detection reactions-polymerase chain reaction; PCR: polymerase chain reaction; SLE: systemic lupus erythematosus; BD: Behçet's disease; IL-10: interlukin-10; LPS: lipopolysaccharide; PBMC: peripheral blood mononuclear cells; CWP: coal workers' pneumoconiosis; TNF-α: tumor necrosis factor-α. 30907204

2019

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.700 Biomarker BEFREE Actual Anti-TNF Trough Levels Relate to Serum IL-10 in Drug-Responding Patients With Crohn's Disease. 30776076

2019

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.700 Biomarker BEFREE One of the most common murine models for studying CD is IL-10-/- mouse. 31509557

2019

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.700 AlteredExpression BEFREE In addition, the levels of IgG x TNF, IgA x IL-10 and IgG x IL-10 were also correlated in CD, indicating that ASCA production may be influenced by the inflammatory response. 30884988

2019

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.700 Biomarker BEFREE Furthermore, in CD, circRNA_103516 correlated positively with CDAI (<i>P</i> < 0.001), CRP (<i>P</i> < 0.001), ESR (<i>P</i> < 0.001), TNF-α (<i>P</i> < 0.001), and IFN-γ (<i>P</i> < 0.001) and negatively correlated with IL-10 (<i>P</i> = 0.006). 31749597

2019

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0010346
Disease: Crohn Disease
Crohn Disease
0.700 AlteredExpression BEFREE Additionally, lncRNA ANRIL expression was negatively associated with Crohn's disease activity index (P = 0.002), C-reactive protein (P < 0.001) and erythrocyte sedimentation rate (P = 0.001), and associated with tumor necrosis factor-α (P < 0.001), IL-17 (P < 0.001) and interferon gamma messenger RNA levels (P = 0.004) but positively associated with IL-10 messenger RNA level (P = 0.002). 30665494

2019

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 Biomarker BEFREE Here, we show that in a murine inflammatory bowel disease (IBD) model based on macrophage-restricted interleukin-10 (IL-10) receptor deficiency (<i>Cx3cr1<sup>Cre</sup>:Il10ra<sup>fl/fl</sup></i> mice), proinflammatory mutant gut macrophages cause severe spontaneous colitis resembling the condition observed in children carrying IL-10R mutations. 31201258

2019

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 Biomarker BEFREE However, little is known regarding the role of PI3Kδ on IL-10-producing B cells that help regulate mucosal inflammation in IBD. 31546615

2019

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 AlteredExpression BEFREE Consistent with the PBMC data, both <i>L. fermentum</i> KBL374- and KBL375-treated DSS mice demonstrated decreased Th1-, Th2-, and Th17-related cytokine levels and increased IL-10 in the colon compared with the DSS control mice.Administration of <i>L. fermentum</i> KBL374 or KBL375 to mice increased the CD4+CD25+Foxp3+Treg cell population in mesenteric lymph nodes.Additionally, <i>L. fermentum</i> KBL374 or KBL375 administration reshaped and increased the diversity of the gut microbiota.In particular, <i>L. fermentum</i> KBL375 increased the abundance of beneficial microorganisms, such as <i>Lactobacillus</i> spp. and <i>Akkermansia</i> spp.Both <i>L. fermentum</i> KBL374 and KBL375 may alleviate inflammatory diseases, such as inflammatory bowel disease, in the gut by regulating immune responses and altering the composition of gut microbiota. 30939976

2019

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 Biomarker BEFREE Loss of IL-10 promotes the development of inflammatory bowel disease (IBD) as a consequence of an excessive immune response to the gut microbiota. 31727465

2019

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 Biomarker BEFREE Ascl2 facilitates IL-10 production in Th17 cells to restrain their pathogenicity in inflammatory bowel disease. 30722992

2019

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 Biomarker BEFREE We observed that C3H ASF and 129 ASF IL-10 are more sensitive towardB7 600 μg/mL vitamin B<sub>3</sub> and 1,200 μg/mL vitamin C. The lowest growth rate and viability for all types of organoids was with 1,200 μg/mL vitamin C. From quantitative polymerase chain reaction analysis (qPCR analysis), MUC2 was upregulated for 129 ASF and C3H Conv when exposed to 600 μg/mL and 1,200 μg/mL vitamin C. It suggests that large amounts of glycoprotein may be produced after adding high concentrations of vitamin C. Since inflammatory bowel disease has low level of MUC2, this finding may be helpful in restoring mucosal health by upregulating the MUC2 gene while altering patient's microbiota (Sibila et al., Annals of the American Thoracic Society, 2016). 31071241

2019

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 GeneticVariation BEFREE Mutations in interleukin-10 and its receptors cause infantile inflammatory bowel disease (IBD), a hyperinflammatory disorder characterized by severe, treatment-refractory colitis, multiple abscesses, and enterocutaneous fistulas. 29683948

2019

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 Biomarker BEFREE IL10 is an anti-inflammatory cytokine, so Tr1 cells might be used in the treatment of inflammatory bowel diseases. 31513797

2019

Entrez Id: 3586
Gene Symbol: IL10
IL10
CUI: C0021390
Disease: Inflammatory Bowel Diseases
Inflammatory Bowel Diseases
0.700 Biomarker BEFREE We investigated two main types of Tregs, the CD4+FOXP3+ and IL-10+ Tr1, in pediatric subjects with inflammatory bowel disease (IBD) both at diagnosis and after the clinical remission. 31715619

2019