Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3664
Gene Symbol: IRF6
IRF6
CUI: C0000846
Disease: Agenesis
Agenesis
0.040 Biomarker BEFREE Since tooth agenesis is commonly found in individuals with cleft lip/palate (CL/P), we used four large cohorts to evaluate if IRF6 and TGFA interaction contributes to CL/P. 23029012

2012

Entrez Id: 3664
Gene Symbol: IRF6
IRF6
CUI: C0000846
Disease: Agenesis
Agenesis
0.040 GeneticVariation BEFREE Here we report the first study to investigate whether IRF6 variation is associated with palatine rugae patterns in a population with sporadic tooth agenesis. 20032603

2009

Entrez Id: 3664
Gene Symbol: IRF6
IRF6
CUI: C0000846
Disease: Agenesis
Agenesis
0.040 GeneticVariation BEFREE A haplotype involving the most 5'IRF6 markers was associated with sporadic tooth agenesis (p=0.006). 18452891

2008

Entrez Id: 3664
Gene Symbol: IRF6
IRF6
CUI: C0000846
Disease: Agenesis
Agenesis
0.040 GeneticVariation BEFREE The same variants in the IRF6 gene that are associated with isolated orofacial clefts are also associated with human tooth agenesis (rs861019, P = 0.058; rs17015215-V274I, P = 0.0006; rs7802, P = 0.004). 17318851

2007