Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.350 Therapeutic CTD_human Intralymphatic interleukin-2 in combination with zidovudine for the therapy of patients with AIDS. 9861562

1999

Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.350 Biomarker BEFREE In view of its similarity to IL-2 in its effects on immune cells, we sought to determine whether IL-15 can induce the expansion of AIDS virus-specific pre-CTL to mature CTL. 8871670

1996

Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.350 AlteredExpression BEFREE Functionally, the IL-2R+ monocytes were capable of depleting IL-2 from culture supernatants, suggesting a mechanism for the reduced IL-2 levels commonly seen in AIDS patients. 2295695

1990

Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.350 Biomarker BEFREE Events in the human interleukin 2-dependent helper T-cell line WE17/10 are similar in several respects to the clinical progression in acquired immunodeficiency syndrome. 2144349

1990

Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.350 GeneticVariation BEFREE Acquired immune deficiency syndrome in childhood: impaired production of interleukin-2 by HIV (LAV/HTLV III) infected patients. 2954915

1987

Entrez Id: 3558
Gene Symbol: IL2
IL2
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.350 Biomarker BEFREE It was possible that T-cell depletion in acquired immune deficiency syndrome could be due to an impairment of TCGF synthesis and that adult T-cell leukemia could be due to unregulated production of TCGF. 3001715

1985

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.320 Biomarker BEFREE Furthermore, IFN-γ is an important pathogenetic factor in some immune-mediated bone diseases including rheumatoid arthritis, postmenopausal osteoporosis, and acquired immunodeficiency syndrome. 30008722

2018

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.320 Biomarker CTD_human Effect of zidovudine therapy in patients with HIV infection on endogenous interferon plasma levels and the hepatic cytochrome P450 enzyme system. 9612607

1998

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.320 Biomarker BEFREE Interferon gamma receptor knockout mice developed a chronic infection when inoculated with spores of Encephalitozoon intestinalis which is a cause of intestinal microsporidiosis in AIDS patients. 9229392

1996

Entrez Id: 3439
Gene Symbol: IFNA1
IFNA1
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.300 Biomarker CTD_human Effect of zidovudine therapy in patients with HIV infection on endogenous interferon plasma levels and the hepatic cytochrome P450 enzyme system. 9612607

1998

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.200 AlteredExpression BEFREE The intestinal microbiota of AIDS/HIV patients were disordered, and there was a correlation between the amount of intestinal flora and the number of CD4+ T lymphocytes and the levels of TNF-α and IL-6. 31489799

2020

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.200 AlteredExpression BEFREE Compared to healthy HIV-negative controls, the colon of AIDS patients was highly inflamed with increased infiltration of inflammatory cells and increased mRNA expression of proinflammatory cytokine (tumour necrosis factor (TNF)-α, interleukin (IL)-1β, IFN-γ, and IL-18), chemokines (chemokine (C-C motif) ligand (CCL)2 and chemokine (C-X-C) motif ligand (CXCL)10) and transcription factors (TNF receptor-associated factor (TRAF)6 and T-box (TXB)21). 26475133

2015

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.200 GeneticVariation GWASDB Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02). 19115949

2009

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.200 GeneticVariation BEFREE This study highlights that polymorphic sites spanning the region nearby the TNF locus are associated with AIDS per se and with cytomegalovirus retinitis in AIDS patients. 19542865

2009

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.200 Biomarker BEFREE The simian M. avium isolate grew significantly better than did an isolate from an AIDS patient or a chicken isolate (P = .001); it induced significantly more TNF-alpha production in Mphis from SIV-positive and SIV-negative monkeys than did the isolate from an AIDS patient (P = .013). 10194069

1999

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.200 Biomarker BEFREE Indeed, elevated expression of cytokines such as interleukin (IL)-1 and tumor necrosis factor-alpha (TNF-alpha), thought to be neurotoxic, has been found in AIDS patients. 8740230

1996

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.200 Biomarker BEFREE For example, concentration of TNF-alpha is increased in brain tissue of individuals who died with AIDS and correlates with the severity of AIDS Dementia Complex (ADC). 8903854

1995

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.200 Biomarker BEFREE Thus, TNF-alpha inhibitors may alleviate some of the neurological manifestations of acquired immunodeficiency syndrome. 7695238

1995

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.200 AlteredExpression BEFREE Increased levels of tumor necrosis factor-alpha messenger RNA were not associated with increased levels of IL-1 beta messenger RNA, suggesting differential regulation of these monokines in acquired immunodeficiency syndrome dementia.(ABSTRACT TRUNCATED AT 250 WORDS) 8498837

1993

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.200 AlteredExpression BEFREE This study demonstrates the safety of pentoxifylline in AIDS patients and its ability to decrease triglycerides and TNF mRNA levels. 8099612

1993

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.200 AlteredExpression BEFREE In in situ hybridization experiments, TNF-alpha mRNA was shown to be abundantly present in colonic mucosa from AIDS patients with CMV colitis but not in colonic mucosa from control (AIDS and normal) subjects. 1331170

1992

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.140 GeneticVariation GWASDB Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02). 19115949

2009

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.140 GeneticVariation GWASCAT Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02). 19115949

2009

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.140 GeneticVariation BEFREE The HLA-B*5703 allele confers susceptibility to the development of spondylarthropathies in Zambian human immunodeficiency virus-infected patients with slow progression to acquired immunodeficiency syndrome. 15641063

2005

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0001175
Disease: Acquired Immunodeficiency Syndrome
Acquired Immunodeficiency Syndrome
0.140 Biomarker LHGDN Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. 12134147

2002