Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1378
Gene Symbol: CR1
CR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation GWASCAT Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project. 31473137

2019

Entrez Id: 1378
Gene Symbol: CR1
CR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 Biomarker BEFREE Our main findings were i) we were able to build generalizable models with clinically relevant accuracy (~93%) for identifying MCI individuals who progress to AD within 3 years; ii) markers of AD pathophysiology (amyloid, tau, neuronal injury) accounted for large shares of the variance in predicting progression; iii) our methodology allowed us to discover that expression of CR1 (complement receptor 1), an AD susceptibility gene involved in immune pathways, uniquely added independent predictive value. 30783207

2019

Entrez Id: 1378
Gene Symbol: CR1
CR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation GWASCAT Shared genetic architecture between metabolic traits and Alzheimer's disease: a large-scale genome-wide cross-trait analysis. 30805717

2019

Entrez Id: 1378
Gene Symbol: CR1
CR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation GWASCAT Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. 30617256

2019

Entrez Id: 1378
Gene Symbol: CR1
CR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 Biomarker BEFREE The involvement of CR1 in the pathogenesis of AD might be linked to insufficient clearance of amyloid deposits. 30044434

2018

Entrez Id: 1378
Gene Symbol: CR1
CR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation GWASCAT GWAS on family history of Alzheimer's disease. 29777097

2018

Entrez Id: 1378
Gene Symbol: CR1
CR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 Biomarker BEFREE Genetic polymorphisms in several genes, including APOE (Apolipoprotein E), PSEN1 (Presenilin 1), CR1 (Complement receptor 1), and PICALM (Phosphatidylinositol binding clathrin assembly protein), have been associated to an increased AD risk. 30040717

2018

Entrez Id: 1378
Gene Symbol: CR1
CR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE SNP effects on erythrocyte CR1 likely underlie the association of CR1 polymorphisms with AD risk. 29792870

2018

Entrez Id: 1378
Gene Symbol: CR1
CR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE The AD susceptibility genes apolipoprotein E (<i>APOE</i>), phosphatidylinositol binding clathrin assembly protein (<i>PICALM</i>), complement receptor 1 (<i>CR1</i>) and clusterin (<i>CLU</i>) are involved in the HSV lifecycle. 29559905

2018

Entrez Id: 1378
Gene Symbol: CR1
CR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 AlteredExpression BEFREE ADE levels of complement regulatory proteins CD59, CD46, decay-accelerating factor (DAF), and complement receptor type 1, but not factor I, were significantly lower for AD patients than controls (p < 0.0001 for CD59 and DAF), were diminished by the AD1 stage, and were further decreased at the AD2 stage. 29406582

2018

Entrez Id: 1378
Gene Symbol: CR1
CR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE Complement receptor 1 gene (CR1) intragenic duplication and risk of Alzheimer's disease. 29675612

2018

Entrez Id: 1378
Gene Symbol: CR1
CR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE These data indicate that genetic variation within the CR1 gene is associated not only with Alzheimer's disease, but also with general cognitive function during late life. 29212848

2018

Entrez Id: 1378
Gene Symbol: CR1
CR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE However, to date, few studies were performed to discover the possible effect of CR1 genetic variants on AD pathology in the brain. 26742530

2017

Entrez Id: 1378
Gene Symbol: CR1
CR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE CR1 polymorphisms elevate AD risk, and >80% of human CR1 is vested in erythrocytes to subserve immune adherence. 28475854

2017

Entrez Id: 1378
Gene Symbol: CR1
CR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 AlteredExpression BEFREE As a receptor for the complement components C3b and C4b, CR1 regulates the activation of the complement cascade and promotes the phagocytosis of immune complexes and cellular debris, as well as the amyloid-beta (Aβ) peptide in Alzheimer's disease (AD). 28745649

2017

Entrez Id: 1378
Gene Symbol: CR1
CR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 Biomarker BEFREE Single nucleotide polymorphisms (SNPs) in and near ABCA7, BIN1, CASS4, CD2AP, CD33, CELF1, CLU, complement receptor 1 (CR1), EPHA1, EXOC3L2, FERMT2, HLA cluster (DRB5-DQA), INPP5D, MEF2C, MS4A cluster (MS4A3-MS4A6E), NME8, PICALM, PTK2B, SLC24A4, SORL1, and ZCWPW1 have been associated with Alzheimer's disease (AD) in large meta-analyses. 27005436

2016

Entrez Id: 1378
Gene Symbol: CR1
CR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation GWASCAT A novel Alzheimer disease locus located near the gene encoding tau protein. 25778476

2016

Entrez Id: 1378
Gene Symbol: CR1
CR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE Recent large genome wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) in the C3b/C4b receptor (CR1 or CD35) that are associated with late onset AD. 26914463

2016

Entrez Id: 1378
Gene Symbol: CR1
CR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE Our analysis further supports previous findings that the CR1 rs6656401 polymorphism contributes to AD susceptibility. 24878768

2015

Entrez Id: 1378
Gene Symbol: CR1
CR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 Biomarker BEFREE These observations indicate that AD susceptibility is associated with the long CR1 isoform (CR1*2), albeit at a lower density, suggesting that AD results from insufficient clearance of plaque deposits rather than increased inflammation. 25666996

2015

Entrez Id: 1378
Gene Symbol: CR1
CR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation GWASCAT Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. 24162737

2013

Entrez Id: 1378
Gene Symbol: CR1
CR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation GWASDB Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. 24162737

2013

Entrez Id: 1378
Gene Symbol: CR1
CR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE We investigated the influence of the rs6656401 single nucleotide polymorphisms (SNP) of the CR1 gene, the rs3851179 SNP of the PICALM gene, and the rs11136000 SNP of the CLU gene on risk of AD in a Polish population. 23650005

2013

Entrez Id: 1378
Gene Symbol: CR1
CR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 GeneticVariation BEFREE These findings question a role for the Ser1610Thr variant in AD risk and related endophenotypes, and reaffirm our previous observation that the CR1 CNV could be the true functional risk factor explaining the association between CR1 and AD. 23582656

2013

Entrez Id: 1378
Gene Symbol: CR1
CR1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.500 Biomarker BEFREE How precisely the different functional role of CR1-S in the immune complement cascade contributes to AD pathogenesis will need additional functional studies. 21403675

2012