Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 GeneticVariation BEFREE Tauopathies such as Alzheimer's disease (AD), Pick's disease (PiD), Frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) etc. represent a group of age-related neurodegenerative disorders in which tau protein loses its normal conformation mostly due to hyperphosphorylation and subsequent formation of the aggregates of defined shapes, known as Neurofibrillary Tangles (NFTs). 31715291

2020

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE The increase in CLU alloforms was most closely associated with increases in both insoluble Aβ42 and tau protein (p = 0.001), supporting its role in AD pathogenesis. 31813628

2020

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE Misfolding and aggregate formation by the tau protein has been closely related with neurotoxicity in a large group of human neurodegenerative disorders, which includes Alzheimer's disease. 31521630

2020

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE Alzheimer's disease (AD) is characterized by fibrillar deposits of amyloid-β (Aβ) peptides and neurofibrillary tangles of Tau proteins. 31697060

2020

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 AlteredExpression BEFREE Alzheimer's disease (AD) is the most common cause of dementia and is characterized by aggregation of amyloid and tau proteins in the brain. 31694431

2020

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE The pathophysiology involved in AD is intra-neuronal accumulation of hyper-phosphorylated tau protein as neurofibrillary tangle and extra cellular beta amyloid plaque deposition, which is due to oxidative stress. 31585875

2020

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 AlteredExpression BEFREE The current review summarizes recent findings on the possible role of SELENOP in AD, with a focus on probable mechanisms: Se delivery to neurons, antioxidant activity, cytoskeleton assembly, interaction with redox-active metals (e.g., copper and iron), and misfolded proteins (amyloid beta and tau protein). 31250406

2020

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE [<sup>18</sup>F]flortaucipir binds to paired helical filament tau and accurately identifies tau in Alzheimer's disease (AD). 31612245

2020

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 AlteredExpression BEFREE It reversed the increase in hippocampal amyloid beta protein, phosphorylated tau protein contents together with augmentation of neprilysin level, it also diminished levels of nuclear factor kappa-B, FAS ligand, tumor necrosis factor-alpha, malondialdehyde, and acetylcholinesterase content.These findings show the protective action of telmisartan against AD-like pathological alterations. 31332715

2020

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE The microtubule-associated protein Tau is strongly implicated in Alzheimer's disease (AD) and aggregates into neurofibrillary tangles in AD. 31698056

2020

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE This novel tau biomarker could be used to improve diagnosis of Alzheimer's disease and to facilitate the development of drug candidates targeting tau pathology. 31834365

2020

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE Alzheimer's disease (AD) is characterized by the presence of extracellular amyloid β plaques and intraneuronal neurofibrillary tangles of hyperphosphorylated microtubule-associated protein tau in the brain. 31376192

2020

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE As a result, Aβ and Tau generate continually, which aggravates both autophagy dysfunction and AD. 31503421

2020

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE A key knowledge gap blocking development of effective therapeutics for Alzheimer's disease (AD) is the lack of understanding of how amyloid beta (Aβ) peptide and pathological forms of the tau protein cooperate in causing disease phenotypes. 31825838

2019

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 AlteredExpression BEFREE Glycogen synthase kinase 3 (GSK3) has been identified as a promising target for the treatment of Alzheimer's disease (AD), where abnormal activation of this enzyme has been associated with hyperphosphorylation of tau proteins. 31792284

2019

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE Self-assembly of the microtubule-associated protein tau into neurotoxic oligomers, fibrils, and paired helical filaments, and cell-to-cell spreading of these pathological tau species are critical processes underlying the pathogenesis of Alzheimer's disease and other tauopathies. 31046227

2019

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE Brain lesions in Alzheimer's disease (AD) include amyloid plaques made of Aβ peptides and neurofibrillary tangles composed of hyperphosphorylated tau protein with synaptic and neuronal loss and neuroinflammation. 30821420

2019

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE Therapeutic strategies focusing on the reduction of oxidative stress, modulation of amyloid-beta (Aβ) toxicity and inhibition of tau protein hyperphosphorylation are warranted to avoid the development and progression of AD. 30763379

2019

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE In this review, we give a brief description of the pathogenesis of AD and provide detailed discussions about the recent development of chemical structures of anti-AD agents (2013 up to present) that have multiple targets, such as amyloid-β peptide, Tau protein, cholinesterases, monoamine oxidase, β-site amyloid-precursor protein-cleaving enzyme 1, free radicals, metal ions (Fe2+, Cu2+, Zn2+) and so on. 30501591

2019

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 PosttranslationalModification BEFREE Here, we found that streptozotocin (STZ)-induced diabetic rats exhibited poorer performance on the social recognition test, Morris water maze, and plus-maze discriminative avoidance task, compared to PBS-treated normoglycemic control rats, likely resulting from increased brain deposition of amyloid-β peptide aggregates (Aβ) and increased phosphorylation of tau protein, two pathological features of AD. 30958383

2019

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE Compared to older Caucasians, older African Americans have higher risks of developing Alzheimer disease (AD) and lower cerebrospinal fluid (CSF) tau biomarker levels. 31271450

2019

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE The intrinsically disordered tau protein plays a pivotal role in the pathogenesis of Alzheimer's disease (AD) and other human tauopathies. 31470053

2019

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE Alzheimer's disease (AD) and other tauopathies are characterized by intracellular accumulation of microtubule-associated tau protein leading to neurodegeneration. 31156179

2019

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE The formation of senile plaques and neurofibrillary tangles of the tau protein are the main pathological mechanism of Alzheimer's disease (AD). 29338678

2019

Entrez Id: 4137
Gene Symbol: MAPT
MAPT
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.700 Biomarker BEFREE Aggregates of hyperphosphorylated tau protein are a hallmark of Alzheimer's disease (AD) and other tauopathies. 31702011

2019