Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 498
Gene Symbol: ATP5F1A
ATP5F1A
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.540 Biomarker BEFREE ORM-13070 is a useful positron emission tomography ligand, ORM-10921 has demonstrated antipsychotic, antidepressant, and pro-cognitive actions in animals, while ORM-12741 is in clinical development for the treatment of cognitive dysfunction and neuropsychiatric symptoms in Alzheimer's disease. 28855875

2017

Entrez Id: 498
Gene Symbol: ATP5F1A
ATP5F1A
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.540 Biomarker BEFREE This trial evaluated the safety and efficacy of ORM-12741 in patients with Alzheimer's disease (AD). 29067315

2017

Entrez Id: 498
Gene Symbol: ATP5F1A
ATP5F1A
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.540 Therapeutic RGD Protein Drug Targets of Lavandula angustifolia on treatment of Rat Alzheimer's Disease. 25561935

2015

Entrez Id: 498
Gene Symbol: ATP5F1A
ATP5F1A
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.540 AlteredExpression BEFREE These results indicate that Aβ-mediated reduction of ATP synthase activity in AD pathology results from direct binding between Aβ and ATP synthase and inhibition of O-GlcNAcylation of Thr432 residue on ATP5A. 26358770

2015

Entrez Id: 498
Gene Symbol: ATP5F1A
ATP5F1A
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.540 Biomarker CTD_human Proteomic identification of HNE-bound proteins in early Alzheimer disease: Insights into the role of lipid peroxidation in the progression of AD. 19374891

2009

Entrez Id: 498
Gene Symbol: ATP5F1A
ATP5F1A
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease
0.540 Biomarker LHGDN Association of ATP synthase alpha-chain with neurofibrillary degeneration in Alzheimer's disease. 12614671

2003