Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 Biomarker BEFREE CCR6+ ILC3s may play some roles in the development of RA through the production of IL-17 and IL-22. 31470891

2019

Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 Biomarker BEFREE <b>Objectives:</b> To analyze occurrence and plasticity of two recently described distinct subtypes of Th1 cells named classic (CD161-/CCR6-) and non-classic (CD161+/CCR6+) Th1 cells in early rheumatoid arthritis (RA) patients and healthy controls (HCs). 31512538

2019

Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation GWASCAT Genetic influences on susceptibility to rheumatoid arthritis in African-Americans. 30423114

2019

Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation BEFREE Single nucleotide polymorphisms in CCR6 (C-C chemokine receptor type 6) gene have been found to be the possible cause of many diseases like rheumatoid arthritis, psoriasis, lupus nephritis and systemic sclerosis and other autoimmune diseases. 31364806

2019

Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 Biomarker BEFREE CCR6 or its chemokine ligand CCL20 might represent a possible new target for the treatment of RA. 30133119

2018

Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 AlteredExpression BEFREE The high expression of RORγt might facilitate the migration of Th17 cells to inflamed joints via the enhanced expression of CCR6 and contribute to the pathology of RA. 29251019

2018

Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 AlteredExpression BEFREE CCL17, CCL20, and CCL28, which are chemokine ligands of CCR4, CCR6, and CCR10, respectively, were abundantly expressed in RA synovial tissue compared to OA. 30619268

2018

Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation BEFREE Moreover proteins encoded by established genetic risk factors for RA including CCR6, CD226, CSF2, EOMES, ETS1, GATA3, IL2, IL6R, IL23R, IKZF3, IRAK1, IRF4, IRF8, PRKCQ, PRDM1, RBPJ, RUNX1 and TAGAP are directly involved in Th17 cell differentiation and/or function. 29254845

2018

Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 Biomarker BEFREE Evidence of epistatic interaction between DPP4 and CCR6 in patients with rheumatoid arthritis. 27587881

2016

Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 Biomarker BEFREE The well-known CD2, REL, TNFAIP3, IRF5, PTPRC, and CCR6 have been confirmed as RA disease associated loci together with recently discovered BACH2, RASGRP1, and IKZF3 loci, taking all RA patients as a unique phenotype. 26939566

2016

Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 Biomarker BEFREE Moreover, current approaches to target CCR6+ Th cells and future directions of research to find specific CCR6+ Th cell targets in the treatment of patients with RA and other CCR6+ Th cell mediated autoimmune diseases are highlighted. 25828206

2015

Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation GWASCAT High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. 24532676

2015

Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 Biomarker BEFREE CCR6 has been associated with RA in genome-wide association studies and has been shown to be an interesting candidate for a therapeutic approach, considering its and CCL20's expression patterns within the tissue as well as the immune system. 24394994

2014

Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation GWASDB Genetics of rheumatoid arthritis contributes to biology and drug discovery. 24390342

2014

Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation GWASCAT Genetics of rheumatoid arthritis contributes to biology and drug discovery. 24390342

2014

Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation GWASDB Novel risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans. 24782177

2014

Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation GWASCAT Novel risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans. 24782177

2014

Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation BEFREE Direct sequencing of DNA was performed to ascertain whether the functional dinucleotide polymorphism of CCR6 previously identified in RA (CCR6DNP) was also present in SSc. 23983073

2013

Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation GWASCAT High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596

2012

Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation GWASDB High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596

2012

Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation GWASDB Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. 22446963

2012

Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 Biomarker CTD_human High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596

2012

Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 Biomarker BEFREE We previously reported an analysis of single-nucleotide polymorphisms (SNPs) in 3 validated European rheumatoid arthritis (RA) susceptibility loci, TAGAP, TNFAIP3, and CCR6, in African American patients with RA. 22127930

2012

Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 AlteredExpression BEFREE RT-PCR of synovial extracts confirmed the predominance of CCL20/CCR6 mRNA expression in RA synovium. 21724701

2011

Entrez Id: 1235
Gene Symbol: CCR6
CCR6
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.500 GeneticVariation GWASDB A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. 20453841

2010