Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker BEFREE These changes are mirrored in serum and should be considered in the light of the downmodulating role of CD26 in major chemokines related to the pathogenesis of asthma such as CCL11 (eotaxin), CCL5 (RANTES), and CXCL12a (SDF-1α). 29297467

2019

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 AlteredExpression BEFREE No differences in the release or expression of RANTES, IFN-λ1 protein and mRNA, or IFN-α and IFN-β mRNA between asthmatics and healthy controls were observed. 29411555

2018

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 AlteredExpression BEFREE This study was aimed to determine the profiles of serum cytokines (IL-1β, TNF-α, IL-4, IL-5) and chemokines (MCP-1: monocyte chemoattract protein-1 and RANTES: regulated on activation normal T cell expressed and secreted) in individuals with an asthmatic versus a non-asthmatic background with bacterial, viral or mixed acute respiratory infection. 28168862

2017

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker BEFREE These findings suggest that HRV-induced CCL5 can induce ASMC chemotaxis and thus may contribute to the pathogenesis of airway remodeling in patients with asthma. 28257236

2017

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 GeneticVariation BEFREE This meta-analysis suggests that the CCL5 -28C/G polymorphism is a risk factor for asthma. 25898691

2015

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 GeneticVariation BEFREE Association between RANTES gene polymorphisms and asthma: a meta-analysis. 24963658

2014

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 GeneticVariation BEFREE Carriers of both IL-13 A2044G A/A and RANTES G-28C G/G have a more significant risk for developing asthma than those with only a single polymorphism. 24053708

2013

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 GeneticVariation BEFREE The current cluster analysis identified meaningful adult asthma phenotypes linked to the functional CCL5 and ADRB2 genotypes. 23267209

2013

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker BEFREE Treatment with NOD1,2 ligand could induce the subepithelial fibrosis and significantly enhance the serum concentration of total IgE, chemokine CCL5 for eosinophils and T helper type 2 (Th2) cells and asthma Th2 cytokine IL-13 in bronchoalveolar lavage fluid of ovalbumin-sensitized allergic asthmatic mice (all P<0.05). 23524653

2013

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 AlteredExpression BEFREE The presence of increased CCL5 levels in nasal epithelia at the time of bronchiolitis or the development of allergic sensitization by age 3 years are associated with increased likelihood of subsequent asthma. 22444510

2012

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 GeneticVariation BEFREE Previous studies revealed that polymorphisms of RANTES were implicated in susceptibility to asthma, but a large number of studies reported apparently conflicting results. 20430255

2010

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 GeneticVariation BEFREE A number of studies have evaluated the functional polymorphism -28C/G in the RANTES promoter region, which had been found to affect the transcription of the RANTES gene, in relation to asthma susceptibility. 20186291

2010

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker RGD Role of the extracellular signal-regulated kinase 1/2 signaling pathway in regulating the secretion of bronchial smooth muscle cells in a rat model of chronic asthma. 18208670

2008

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker LHGDN It was previously reported that the gain-of-function -28 guanine allele of the promoter single nucleotide polymorphism (SNP; cytosine to guanine substitution of nucleotide -28 (-28C>G)) in the CC chemokine ligand 5 gene (CCL5) was associated with susceptibility to late-onset asthma in patients who developed asthma at age > or =40 yrs. 18385174

2008

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 GeneticVariation LHGDN The polymorphisms within the RANTES promoter may have a disease-modifying effect in Korean children with asthma. 17990036

2008

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 GeneticVariation BEFREE The polymorphisms within the RANTES promoter may have a disease-modifying effect in Korean children with asthma. 17990036

2008

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 GeneticVariation BEFREE Our objective was to investigate the possible influence of the CCL5/RANTES promoter polymorphisms in the different types of bronchial asthma. 18186796

2008

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker BEFREE C-C chemokines such as CCL11, CCL5, and CCL3 are central mediators in the pathogenesis of asthma. 18178867

2008

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 GeneticVariation BEFREE It was previously reported that the gain-of-function -28 guanine allele of the promoter single nucleotide polymorphism (SNP; cytosine to guanine substitution of nucleotide -28 (-28C>G)) in the CC chemokine ligand 5 gene (CCL5) was associated with susceptibility to late-onset asthma in patients who developed asthma at age > or =40 yrs. 18385174

2008

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 AlteredExpression BEFREE There was a weak and negative correlation between T-bet expression and RANTES level in the asthmatics (r=-0 x 29, P=0 x 032). 17302903

2007

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 GeneticVariation BEFREE Our data suggest that -28 C/G and -403 G/A polymorphisms within the RANTES promoter region play an important role in asthma predisposition and in the severity of airway obstruction. 17678722

2007

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker BEFREE RANTES is genetically associated with asthma, sarcoidosis and multiple sclerosis. 16855620

2006

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 GeneticVariation BEFREE Although there are several reports on the association of RANTES promoter polymorphisms (-403G/A and -28C/G) with asthma, the association of these polymorphisms with atopic dermatitis has not yet been confirmed in other populations. 17117952

2006

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 Biomarker LHGDN RANTES production from mononuclear cells in response to the specific allergen in asthma patients. 17075265

2006

Entrez Id: 6352
Gene Symbol: CCL5
CCL5
CUI: C0004096
Disease: Asthma
Asthma
0.600 GeneticVariation BEFREE We studied 61 patients with asthma and/or atopy and 129 to 157 newborn controls for the -403 RANTES, -28 RANTES, and -1055 IL-13 SNPs, as well as 47 patients and 60 newborn controls for the -444 LTC4S SNP. 16024972

2005