Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE Asthma model was induced using ovalbumin (OVA) method and AMSC hyperplasia model was induced using TGF-β1. 31733831

2020

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE Here, we assessed whether TGF-β1 affects the ability of HASM cells to relax in response to β<sub>2</sub>-agonists, a mainstay treatment for airway hyperresponsiveness in asthma. 30742476

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression BEFREE Among elderly asthmatics, subjects with severe asthma had lower FEV1 (% predicted) value, but showed significantly higher serum levels of eotaxin-2 and TGF-β1, than those with non-severe asthma (<i>P</i> < 0.05 for each). 30479079

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE Taken together, the present results have revealed that PCA inhibits asthma airway remodeling by suppressing proliferation and extracellular matrix (ECM) protein deposition in TGF-β1-mediated ASMCs via the inactivation of Smad2/3 signaling pathway. 30472056

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE MicroRNA-744 Inhibits Proliferation of Bronchial Epithelial Cells by Regulating Smad3 Pathway via Targeting Transforming Growth Factor-β1 (TGF-β1) in Severe Asthma. 30903795

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE In the current study, we found that miR-448-5p was dramatically decreased in lung tissues of asthmatic mice and TGF-β1-stimulated bronchial epithelial cells. 30362537

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE Cryptotanshinone Attenuates Airway Remodeling by Inhibiting Crosstalk Between Tumor Necrosis Factor-Like Weak Inducer of Apoptosis and Transforming Growth Factor Beta 1 Signaling Pathways in Asthma. 31780948

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression BEFREE Immunofluorescence showed that ROS and TGF-β1 expression was significantly increased in lung tissue from the OVA-induced asthma model. 30092299

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE It will further review the evidence demonstrating the extent to which IL-17A interacts with various immune factors, specifically TGF-β1, to contribute to ASM remodeling and altered function in T<sub>H</sub>17-driven endotypes of severe asthma. 30810068

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE The exhaled-TGF-β1 levels were significantly lower in those children with asthma exacerbation when compared to the stable asthmatic children (<i>p</i> = 0.0003).<b>Conclusion:</b> Our results suggest that TGF-β1 may play a role in suppressing airway reactivity and its deficiency is associated with asthma exacerbation.AbbreviationsACTAsthma control testAHRAirway hyper-reactivityASMAirway smooth muscleBALBronchoalveolar lavageELISAEnzyme-linked immunoassayEIBExercise-induced bronchospasmEBCExhaled breath condensateFEV1Forced expiratory volume in the first secondFEV1/FVCForced expiratory volume in the first second/forced vital capacityFEF25%-75%Forced expiratory flow, midexpiratory phaseGINAGlobal Initiative for Asthma(Ig)EImmunoglobulin EISAACInternational Study of Asthma and Allergies in ChildhoodIQRInterquartile rangeIL-10Interleukin-10TGF-β1Transforming growth factor-β1Treg cellsT regulatory cells. 31709879

2019

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression BEFREE In conclusion, the results suggested that TGF-β1 enhances ADAM33 expression in airway epithelial cells, and that ADAM33 induces the EMT of airway epithelial cells, thus participating in airway remodeling in asthma. 29399106

2018

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression BEFREE Taken together, these results demonstrate that SIRT7 is involved in regulating TGF-β1-induced ASM cell proliferation and migration by regulating the expression of TβRI, thus indicating an important role of SIRT7 during airway remodeling in asthma. 29843083

2018

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE Altered pattern of monocyte differentiation and monocyte-derived TGF-β1 in severe asthma. 29343695

2018

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE However, the role of TGF-β1 in excessive airway narrowing in asthma, or airway hyperresponsiveness (AHR), remains unclear. 28984468

2018

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE The results showed that RAGE inhibition or RAGE knockdown decreased β-catenin nuclear accumulation and the expression of relevant β-catenin targeted genes (VEGF, MMP9, TGF-β1) in the TDI-induced murine asthma model and TDI-HSA-treated 16HBE cells, respectively. 29656209

2018

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression BEFREE We found significantly decreased Bcl11b but increased IL-17A and TGF-β1 expression in patients with asthma and a strongly negative correlation between Bcl11b and these 2 cytokines in SA patients. 30088373

2018

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 GeneticVariation BEFREE The aim of this meta-analysis was to evaluate the relation of two transforming growth factor-β1 (TGF-β1) polymorphisms with asthma risk in Chinese population. 29958018

2018

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE Our results associating TGFB1 and TLE4 with clinical features of asthma suggest potential application of these parameters in the management of asthma children. 28262390

2018

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE On the other hand, TGF-β1 is increased in the lungs of individuals with asthma and may modulate airway inflammation. 28284979

2017

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE TGF-β1 is an important cytokine in airway remodeling in asthma. 27905842

2017

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE A total of 58 asthmatic patients (33 with severe refractory asthma (SRA)) and 10 healthy controls underwent sputum induction for % cells, activin A, follistatin, eosinophilic cationic protein (ECP), transforming growth factor beta 1 (TGF-β1), IL-13 and IL-8 measurements. 27807906

2017

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE Ovalbumin induced rat asthma model and TGF-β1-induced BEAS-2B cell apoptosis model were established, respectively. 27916734

2017

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 Biomarker BEFREE Through our review, we aim to further elucidate the role of TGF-β1 in asthma pathogenesis and the link between airway remodeling and airway hyperresponsiveness in asthma and to define TGF-β1 as a potential therapeutic target for reducing asthma morbidity and mortality. 27854509

2017

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression BEFREE The aim of the present study was to evaluate the effect of TGF-β1 mRNA expression on IL-15 mRNA expression in asthmatic patients and to assess the role of IL-15 in the clinical course of asthma. 29104662

2017

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0004096
Disease: Asthma
Asthma
0.700 AlteredExpression BEFREE GSDMB regulates expression of 5-LO and TGF-β1 which are known pathways involved in the pathogenesis of asthma. 28826527

2017