Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7038
Gene Symbol: TG
TG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.500 Biomarker BEFREE The following terms were used for the search: [subclinical hypothyroidism OR thyroid autoimmunity OR thyroperoxidase antibody (TPO-Ab) OR thyroglobulin antibodies (Tg-Ab)] AND (levothyroxine OR euthyrox) AND [pregnancy outcome OR miscarriage OR abortion OR pregnancy loss OR preterm birth OR premature delivery OR early labo(u)r]. 30951172

2019

Entrez Id: 7038
Gene Symbol: TG
TG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.500 Biomarker BEFREE Thyroid autoimmunity (antibodies against thyroid peroxidase [TPO-Abs] and thyroglobulin [TG-Abs]) and thyroid function (thyroid-stimulating hormone [TSH] and free thyroxin [FT4]) were determined. 31529601

2019

Entrez Id: 7173
Gene Symbol: TPO
TPO
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.500 Biomarker BEFREE We aimed to assess the prevalence of thyroid dysfunction and autoimmunity (antithyroid peroxidase auto-antibodies [TPO-Ab]) in patients on first-line HAART, identify risk factors for thyroid dysfunction and determine any association of thyroid dysfunction with HAART. 31044758

2019

Entrez Id: 7173
Gene Symbol: TPO
TPO
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.500 Biomarker BEFREE Thyroid autoimmunity (antibodies against thyroid peroxidase [TPO-Abs] and thyroglobulin [TG-Abs]) and thyroid function (thyroid-stimulating hormone [TSH] and free thyroxin [FT4]) were determined. 31529601

2019

Entrez Id: 7173
Gene Symbol: TPO
TPO
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.500 Biomarker BEFREE The following terms were used for the search: [subclinical hypothyroidism OR thyroid autoimmunity OR thyroperoxidase antibody (TPO-Ab) OR thyroglobulin antibodies (Tg-Ab)] AND (levothyroxine OR euthyrox) AND [pregnancy outcome OR miscarriage OR abortion OR pregnancy loss OR preterm birth OR premature delivery OR early labo(u)r]. 30951172

2019

Entrez Id: 7038
Gene Symbol: TG
TG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.500 AlteredExpression BEFREE Elevated TgAb levels are associated with symptom burden in HT patients, suggesting a role of thyroid autoimmunity in clinical manifestations of HT. 30332318

2019

Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.500 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370

2019

Entrez Id: 7173
Gene Symbol: TPO
TPO
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.500 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370

2019

Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.500 GeneticVariation BEFREE For Caucasian females, PTPN22 SNP rs2476601 was significantly associated with autoimmune disease by allelic association tests (OR = 1.99, [1.30-3.04]). 31759816

2019

Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.500 GeneticVariation BEFREE Results set-up the stage for ultimate trials in the treatment of autoimmunity based on the specific inhibitory targeting of C1858T PTPN22 by lipoplexes. 30439564

2019

Entrez Id: 7173
Gene Symbol: TPO
TPO
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.500 Biomarker BEFREE Autoimmunity to TPO is characterised by autoantibodies and T cell reactivity in Hashimoto's disease and Graves' disease. 30742860

2019

Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.500 GeneticVariation BEFREE We synthesized all meta-analyses reporting a genetic association of the PTPN22 1858T C/T polymorphism with autoimmune diseases. 30871019

2019

Entrez Id: 7038
Gene Symbol: TG
TG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.500 Biomarker BEFREE Emerging evidence revealed that thyroglobulin (TG) contributes to the development of autoimmune disease, and the relationship between TG and autoimmune thyroid disease (AITD) is still controversial. 30139952

2019

Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.500 GeneticVariation BEFREE Our data showed that the PTPN22 R620W polymorphism is a risk factor for TA (CC vs. CT: OR 4.3, p = 0.002, and C vs. T: OR 4.1, p = 0.003); however, the PTPN22 R263Q and - 1123G/C polymorphisms are not associated with this AD. 30470857

2019

Entrez Id: 7173
Gene Symbol: TPO
TPO
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.500 GeneticVariation BEFREE However, the subset of hypothyroidism single-nucleotide polymorphisms involved in autoimmunity and thyroid peroxidase antibodies levels were not associated with AF. 30673084

2019

Entrez Id: 7038
Gene Symbol: TG
TG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.500 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370

2019

Entrez Id: 7038
Gene Symbol: TG
TG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.500 Biomarker BEFREE Serum levels of thyroid-stimulating hormone, free thyroxine and thyroglobulin were not affected by the treatment, and neither was the thyroid autoimmunity status of participants. 30735751

2019

Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.500 GeneticVariation BEFREE A variant in protein tyrosine phosphatase non-receptor type 22 (PTPN22) is associated with reduced risk of developing IBD, but promotes the onset of autoimmune disorders. 31107248

2019

Entrez Id: 7173
Gene Symbol: TPO
TPO
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.500 AlteredExpression BEFREE Instead thyroid peroxidase, one of the major thyroid autoantigens, is also expressed in breast tissue and therefore represents the main antigenic link between thyroid autoimmunity and breast cancer. 31128301

2019

Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.500 GeneticVariation BEFREE Protein-tyrosine phosphatase nonreceptor type 22 (PTPN22) is a lymphoid-specific tyrosine phosphatase (LYP), and mutations in the <i>PTPN22</i> gene are highly correlated with a spectrum of autoimmune diseases. 30979725

2019

Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.500 GeneticVariation BEFREE Attenuated T cell receptor (TCR) signalling contributes to the susceptibility for autoimmunity as shown via mutants of PTPN22 and Zap70 genes. 29105157

2018

Entrez Id: 7173
Gene Symbol: TPO
TPO
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.500 Biomarker BEFREE <sup>131</sup>I-IGD was more common in patients with pre-treatment direct or indirect signs of autoimmunity: positive anti-TPO (p < 0.05), glandular hypoechogenicity, TRAbs within reference range, diffuse uptake on 99mTc-pertechnetate scans (p < 0.05), findings that may increase the risk tenfold. 29353393

2018

Entrez Id: 26191
Gene Symbol: PTPN22
PTPN22
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.500 Biomarker BEFREE These findings highlight PTPN22 as a novel regulator of dectin-1 signals, providing a link between genetically conferred perturbations of innate receptor signaling and the risk of autoimmune disease. 28948613

2018

Entrez Id: 7173
Gene Symbol: TPO
TPO
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.500 Biomarker BEFREE Although numerous papers demonstrated the significant increase in the prevalence of thyroid autoimmunity (positive intrathyroidal lymphocyte infiltration and/or anti-thyroglobulin/thyroid peroxidase antibodies) in patients with thyroid cancers as compared to those with benign nodules, and also the significant increase in the prevalence of papillary thyroid cancer (PTC) in patients with thyroid autoimmunity as compared to those without, there are some crucial biases that should be taken into account for their interpretation. 30081426

2018

Entrez Id: 7038
Gene Symbol: TG
TG
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases
0.500 Biomarker BEFREE Thyroglobulin antibody (TgAb) is a class G immunoglobulin and a conventional marker for thyroid autoimmunity. 30396251

2018