Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Patients with ER+, IGF-1R-positive breast cancer without p-IGF-1R/InsR staining (n = 242) had tamoxifen benefit (HR 0.41, p = 0.0038), while the results for p-IGF-1R/InsR-positive patients (n = 125) were not significant (HR 0.95, p = 0.3). 31490549

2020

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Differential Effects of Insulin and IGF1 Receptors on ERK and AKT Subcellular Distribution in Breast Cancer Cells. 31771180

2019

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 AlteredExpression BEFREE The regulation of IGF-1 expression by leptin in breast cancer cells is unclear. 30293548

2019

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 PosttranslationalModification BEFREE In other 60 clinical samples, methylation specific polymerase chain reaction (PCR) and reverse transcription quantitative PCR were applied for the methylation of HOXA4 and IGF1 genes in BC and adjacent non-cancerous tissues. 30203578

2019

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 AlteredExpression BEFREE Expression of Breast Cancer-Related Epitopes Targeting the IGF-1 Receptor in Chimeric Human Parvovirus B19 Virus-Like Particles. 31317318

2019

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE We showed that members of the IGF-1/IGFBP-4/PAPP-A axis and FSTL-3 may serve as surrogate markers in breast cancer. 30388235

2019

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Prior studies have found positive associations between circulating IGF-I and the IGF-I:IGFBP-3 ratio and breast cancer risk. 31337427

2019

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Total metabolic rate, physical activity level, mean MET and steps, fatigue, self-perceived cognitive functioning , and biomarkers (C-reactive protein [CRP], interleukin 6, macrophage migration inhibiting factor [MIF], tumor necrosis factor [TNF]-α, brain-derived neurotrophic factor [BDNF], insulin-like growth factor 1 [IGF1]) were assessed in 60 patients with breast cancer in the aftercare phase before ( t<sub>0</sub>) and 8 months after ( t<sub>1</sub>) the intervention. 28617135

2018

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 AlteredExpression BEFREE IGF-1R expression was inversely correlated with patient survival even within hormone receptor-positive breast cancers, indicating reduced overall patient survival with low IGF-1R was not due simply to low IGF-1R expression within TNBCs. 30458886

2018

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 GeneticVariation BEFREE Genetic variants in the insulin-like growth factor-I (IGF-I)/insulin resistance axis may interact with lifestyle factors, influencing postmenopausal breast cancer risk, but these interrelated pathways are not fully understood. 29074537

2018

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE We therefore investigated a role for IGF-1R and t-Darpp in regulating glycolytic capacity in HER2<sup>+</sup> breast cancers.<b>Experimental Design:</b> We examined the relationship between t-Darpp and IGF-1R expression in breast tumors and their respective relationships with patient survival. 29180608

2018

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 AlteredExpression BEFREE High birthweight first pregnancies may increase breast cancer risk, possibly through the association of birthweight with oestrogen and insulin-like growth factor 1 levels. 30286782

2018

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE In addition, we review the rationale for targeting the IGF-1 system in the different BrCa molecular subtypes and in treatment resistant breast tumors with a focus on both the molecular mechanisms and on the clinical perspectives of such approaches in specific population subgroups. 29253837

2018

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE In summary, miR‑203a‑3p may enhance the development and oncogenesis of BC, and IGF1 was defined as a hub gene of miR‑203a‑3p in BC. 30320391

2018

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Insulin Receptor Substrate Suppression by the Tyrphostin NT157 Inhibits Responses to Insulin-Like Growth Factor-I and Insulin in Breast Cancer Cells. 30229539

2018

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE The eAd suppressed the signal transduction of IGF-1R mediated by exogenous IGF-I or IGF-II in breast cancer cell lines through neutralizing both IGF-I and IGF-II. 29910690

2018

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 AlteredExpression BEFREE Together, these results suggest that obesity enhances local invasion of breast cancer cells through increased expression of IGF-1 by mammary ASCs, and weight loss may reverse this tumor-promoting phenotype. 30317122

2018

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE A novel functional crosstalk between DDR1 and the IGF axis and its relevance for breast cancer. 29486622

2018

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE In conclusion, the present study expanded the understanding of the regulatory mechanism of miR‑503 in breast cancer, and implicates the miR‑503/IGF‑1R axis as a potential therapeutic target for breast cancer. 28656281

2017

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE IGF-1-mediated PKM2/β-catenin/miR-152 regulatory circuit in breast cancer. 29162853

2017

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Together, our study implicates phenformin-mediated IGF1/IGF1R regulation as a potential anti-cancer mechanism and supports the development of phenformin and other biguanides as breast cancer therapeutics. 28947975

2017

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 AlteredExpression BEFREE Dual HER/IGF-insulin targeting, and triple targeting with inclusion of anti-estrogen drugs, shows striking anti-tumor activity across breast cancer types, and drugs with broader receptor specificity may be more effective than single receptor selective drugs, particularly for ER- cells. 28236033

2017

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 GeneticVariation BEFREE In the current study, IGF-1 gene polymorphism of SNP variants rs6220 and rs7136446 had no statistically significant association with breast cancer, both in premenopausal and postmenopausal women. 28315227

2017

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 Biomarker BEFREE Identification of B and T cell epitope based peptide vaccine from IGF-1 receptor in breast cancer. 28628857

2017

Entrez Id: 3479
Gene Symbol: IGF1
IGF1
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.600 GeneticVariation BEFREE Seven SNPs in IGF-I and INS genes were associated with breast cancer risk. 28478612

2017