Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 AlteredExpression BEFREE Advanced cancers are associated with a chronic inflammation, especially high interleukin-6 (IL-6) and with various levels of adipokines (leptin and adiponectin), while ghrelin counteracts the anorexigenic effect of leptin in cancer-induced anorexia-cachexia syndrome. 31794851

2020

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker BEFREE We previously found that the human TOV21G cells secrete IL-6 that induces autophagy in reporter cells and cachexia in mice. 31436048

2020

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 AlteredExpression BEFREE The metabolic reduction in cachectic cancer patients was potentially related to the elevated serum level of interleukin-6. 30713247

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker BEFREE Lastly, the correlations between plasma interleukin-6 (IL-6) and lipid metabolism parameters in cachexia patients of different genders were analyzed. 31788012

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker BEFREE In cancer, the pro-inflammatory cytokine interleukin-6 (IL-6) is considered a mediator of cachexia and a potential biomarker, but the relationship between IL-6, weight loss, and cancer stage is unknown. 30497874

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 AlteredExpression BEFREE Systemic IL-6 overexpression in precachectic tumor-bearing Apc<sup>Min/+</sup> mice accelerated cachexia development, which coincided with suppressed basal and eccentric contraction-induced muscle protein synthesis. 29641213

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker BEFREE Based on these findings, we conclude that chronic inflammation (especially that mediated by IL-6) might promote cancer cachexia by regulating WAT lipolysis in early-stage cachexia and browning in late-stage cachexia. 29338749

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 AlteredExpression BEFREE The serum level of the lipopolysaccharide-binding protein, often presented as a reflection of the bacterial antigen load, was not only increased in cachectic mice and cancer patients, but also strongly correlated with the serum IL-6 level and predictive of death and cachexia occurrence in these patients. 29719601

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker BEFREE Collectively, these preclinical findings identify trans-signalling via STAT3 as the signalling modality by which IL-6 promotes muscle wasting in lung cancer cachexia, and therefore support the clinical evaluation of the IL-6 trans-signalling/STAT3 axis as a therapeutic target in advanced lung cancer patients presenting with cachexia. 27893707

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker BEFREE This relationship in the female warrants further investigation, as we have shown that the ability of IL-6 to induce cachexia differs between the sexes. 28292759

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 AlteredExpression BEFREE In lung cancer patients, were cachexia is prevalent, there was a significant correlation between elevated IL-6 expression in the tumor and poor prognosis of the patients. 28515477

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker BEFREE Others and we have shown that IL-6 alone is sufficient to induce cachexia both <i>in vitro</i> and <i>in vivo</i>. 28149280

2016

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 AlteredExpression BEFREE Overall, these results demonstrate short-term PDTC treatment to cachectic mice attenuated cancer-induced disruptions to muscle and liver signaling, and these changes were independent to altered tumor burden and circulating IL-6. 27449092

2016

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 GeneticVariation BEFREE The association of SELP-rs6136, IL6-rs1800796 and AKT1-rs1130233 polymorphisms with cachexia as well as the correlation between cachexia and the candidate polymorphisms and overall survival were analyzed. 25238546

2014

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker BEFREE IL-6 triggers oncogenic/angiogenic signals and the cytokine-dependent pro-cachexia cascade. 24886605

2014

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker BEFREE Clinical trials in non-small cell lung cancer (NSCLC) reveal that IL-6 targeted therapy relieves NSCLC-related anemia and cachexia, although other clinical effects require further study. 24260500

2013

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker BEFREE A marked increase (5-fold) in IL-6 as a result of the interaction between the presence of cachexia and the presence of tumour was observed in the subcutaneous tissue of the patients, yet not in the visceral depot. 23200412

2013

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker BEFREE Interestingly, signs of morbidity (cachexia) in mice treated with MV were not directly associated with tumour burden, but were correlated with the secretion of interleukin-6 by MET-1 cells and host cells. 21325484

2011

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 GeneticVariation LHGDN Association of IL-6 gene polymorphisms with cachexia susceptibility and survival time of patients with pancreatic cancer. 18469355

2008

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker BEFREE At the protein level, TNF-alpha was found expressed only in CIX, whereas IL-1 and IL-6 were not cachexia specific. 17878525

2007

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker BEFREE A highly sensitive ELISA confirmed the multiplex result for increased IL-6 in cachectic patients (P = 0.02). 18006755

2007

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker CTD_human Molecular analysis of xenograft models of human cancer cachexia--possibilities for therapeutic intervention. 17878525

2007

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker LHGDN Impact of weight loss on circulating IL-1, IL-6, IL-8, TNF-alpha, VEGF-A, VEGF-C and midkine in gastroesophageal cancer patients. 17931612

2007

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker BEFREE However, since release of IL-6 is frequent in HCC, especially in its more advanced stages, the use of agents like curcumin or DHMEQ might be beneficial to counteract its adverse systemic effects (e.g., cachexia). 17261774

2006

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker BEFREE Moreover, IL-6 is a pathophysiological factor in several hyperproliferative diseases and the paraneoplastic syndromes that often accompany cancer, such as cachexia and osteoporosis; thus, anti-IL-6 therapy would be useful in treating these entities as well. 16083340

2005