Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 GeneticVariation BEFREE Altogether, this study, for the first time, indicates that natural Cer-RUB nanomicelles offer a feasible approach for efficaciously and safely targeting cancers carrying p53 missense mutations. 31645443

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 GeneticVariation BEFREE In summary, we provide the first set of penetrance estimates for SPC and MPC for TP53 germline mutation carriers, and demonstrate its accuracy for cancer risk assessment. 31719099

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 GeneticVariation BEFREE TP53 mutation carriers were significantly more likely to have early onset cancer (p < 0.001) and bilateral breast cancer (p = 0.03), they and were significantly more likely to respond to carboplatin-based neoadjuvant chemotherapy compared to anthracycline- or taxane-based regimen in terms of pathologic complete response (50% vs. 0%, p = 0.006). 31119730

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 GeneticVariation BEFREE Corrigendum to "Prognostic Effect of Long Noncoding RNA NEAT1 Expression Depends on p53 Mutation Status in Cancer". 31485225

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 GeneticVariation BEFREE It has been recently shown that mutant p53 proteins mediate metabolic changes thereby promoting cancer development and metastases. 31112799

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 AlteredExpression BEFREE Targeting p53 activity has been suggested as an important strategy in cancer therapy. 31526948

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 GeneticVariation BEFREE Many of these mutations resembled TP53 mutations found in cancer: they impaired protein activity, were predicted to be pathogenic, and clustered in exons 5 to 8 and hotspot codons. 31839337

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Finally, the DMAPAPA-CS is applied to deliver the therapeutic p53 gene in A549 bearing mice, showing efficient therapeutic potential for cancer. 31590870

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Altogether, these new insights in p53 pathway regulation are of great interest in cancer and may provide new therapeutic targets. 31665549

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 GeneticVariation BEFREE <i>TP53</i> (tumor protein p53) is a tumor suppressor gene frequently mutated in cancer and implicated in cell-cycle regulation, apoptosis, and angiogenesis. 31564192

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE In this Perspective, we provide insight into understanding p53 as a prion-like protein and propose cancer to be recognized as an amyloid or prion-like disease. 31603660

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE A common facet of these maladies is the transition of a protein from its functional native state into higher order forms, such as oligomers and amyloid fibrils. p53 is an essential tumor suppressor that is prone to such conformational transitions, resulting in its compromised ability to avert cancer. 31841126

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 AlteredExpression BEFREE Hence, the accurate quantification of p53 protein levels has great importance in early diagnosis of cancer. 31610154

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Cancer gene therapy based on p53 tumor suppressor gene supplementation emerges as one of the most challenging and promising strategies. 31711736

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 GeneticVariation BEFREE Resistance to anti-cancer drugs is a major impediment towards efficacious cancer treatment. p53 mutations play an important role in cancer cell resistance to chemotherapeutic drugs. 31841768

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 GeneticVariation BEFREE TP53 and FBXW7 mutations appear to be involved in the development of IBD-associated dysplastic lesions and cancer. 31372648

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 GeneticVariation BEFREE Mutations in TP53 are strongly linked to poor prognosis in a variety of haematological malignancies, including chronic lymphocytic leukaemia (CLL). 30836431

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 GeneticVariation BEFREE Li-Fraumeni syndrome (LFS), caused by the germline mutations in the TP53 gene, leads to significant lifetime risk to cancer in the central nervous system. 31468188

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Taken together, our findings suggest a novel oncogenic function of GRWD1 as a transcriptional regulator of p53 and that GRWD1 might be an attractive therapeutic target and prognostic marker in cancer therapy. 31545368

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 GeneticVariation BEFREE Li-Fraumeni and Li-Fraumeni-like (LFS/LFL) Syndrome are cancer predisposition syndromes caused by germline pathogenic variants in TP53 and are associated with an increased risk of multiple early-onset cancers. 31778928

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 AlteredExpression BEFREE We found that NRF3 promotes tumor growth and malignancy by activating ubiquitin-independent 20S proteasome assembly through inducing the expression of the proteasome maturation protein (POMP) chaperone and thereby degrading the tumor suppressors p53 and Rb. 31742837

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Notably, no individuals with confirmed germline or likely germline TP53 PVs met classic Li-Fraumeni syndrome (LFS) criteria, only 41% met Chompret LFS criteria, and 59% met neither criteria, based upon provider-reported personal and family cancer history. 31490007

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 GeneticVariation BEFREE Radiotherapy-induced malignancies in breast cancer patients with TP53 pathogenic germline variants (Li-Fraumeni syndrome). 31748977

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE This enabled successful estimation of TP53 penetrance for three LFS cancer types: breast (BR), sarcoma (SA), and others (OT), from 186 pediatric sarcoma families collected at MD Anderson Cancer Center. 31719101

2020

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.400 Biomarker BEFREE Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer. 31685430

2020