Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE MYC promotes tryptophan uptake and metabolism by the kynurenine pathway in colon cancer. 31416966

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Bioinformatic analyses were utilized to define the expression of MYC-regulated genes in human colon cancer and metabolomics analyses were used to identify pathways regulated by LEF1 in MYC expressing cells. 31623618

2019

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE The expressions of C-MYC and BCL-2 in colon cancer tissues exhibited high levels of expression, while miR-184 displayed relatively low levels in comparison to the adjacent normal tissues. 28782841

2018

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Among the analyzed genes, 10.5% (42) had no reported link with colon cancer, including the SFRP1, IGF1 and ADH1B (down), and MYC and IL8 (up), whose encoded proteins were most interacting with other proteins from the same or even distinct networks. 28962550

2017

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Besides, an heterogeneous pattern of ARNTL, WEE and c-MYC expression hallmarked the chosen colon cancer cell lines and likely influenced their phenotypic changes. 26768731

2016

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE MYC-nick promotes the migration of colon cancer cells assayed in 3D cultures or grown as xenografts in a zebrafish metastasis model. 27566402

2016

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE c-MYC overexpression is frequently observed in various cancers including colon cancer and regulates many biological activities such as aberrant cell proliferation, apoptosis, genomic instability, immortalization and drug resistance. 25689483

2015

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE C-Myc-activated long noncoding RNA CCAT1 promotes colon cancer cell proliferation and invasion. 25185650

2014

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Masking epistasis between MYC and TGF-β pathways in antiangiogenesis-mediated colon cancer suppression. 24627270

2014

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 GeneticVariation BEFREE We investigated here two 8q24 breast and colon cancer risk alleles in the close vicinity of the MYC gene for their role in the occurrence of distant metastases. 22666420

2012

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human Rapid induction of colon carcinogenesis in CYP1A-humanized mice by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate. 21081470

2011

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 GeneticVariation BEFREE 8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC. 20453196

2010

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 GeneticVariation BEFREE In this study, we confirm the association for several single nucleotide polymorphisms at 8q24 in colon cancer but have not detected any structural role relating to c-MYC amplification or chromosomal fragility. 19690179

2009

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE We investigated the effects of RNA interference-mediated silencing of the c-myc gene on celluar proliferation and apoptosis in human colon cancer HT-29 cells in vitro and in vivo. 19183865

2009

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat. 18283038

2008

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Previous molecular and genetic data implicate the c-myc gene as a critical downstream effector of the Wnt/TCF pathway in colon cancer. 17726380

2007

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Ketogenic HMGCS2 Is a c-Myc target gene expressed in differentiated cells of human colonic epithelium and down-regulated in colon cancer. 16940161

2006

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. 15059925

2004

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Increased expression of a Myc target gene Mina53 in human colon cancer. 14695334

2004

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker CTD_human Altered expression of c-myc, p16 and p27 in rat colon tumors and its reversal by short-term treatment with chemopreventive agents. 12189186

2002

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 GeneticVariation BEFREE We performed dual (two-color) fluorescence in situ hybridization (FISH) by using direct fluorescent labeling probes for C-MYC and chromosome 8 in six gastrointestinal (three stomach and three colon) cancers. 9809036

1998

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Although the c-myc gene is overexpressed in approximately 70% of human colonic cancers, previous studies have not detected frequent gene amplification or rearrangement of c-myc in these tumors, although such amplification has been reported in chemically induced rodent colon cancer and quantitative analysis of gene copy number has shown the gene to be amplified at a low level in mucinous and poorly differentiated human colon carcinomas. 9135021

1997

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE We tested the potential impact of tyrosine phosphorylation on the expression of the c-myc gene in two colon cancer cell lines, HCT8 and SW837. 7642726

1995

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Increased expression of the c-myc gene without gene amplification in human lung cancer and colon cancer cell lines. 3089986

1986

Entrez Id: 4609
Gene Symbol: MYC
MYC
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE More recently, an amplified c-myc gene has been positioned on a chromosomal homogeneous staining region (HSR) in a human colon cancer cell line, COLO 320, with neuroendocrine properties. 6646201

1984