Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Our data suggests that colon cancer cells are able to promote self-growth through the secretion of exosomes, especially under hypoxic conditions, which shortens mitosis duration and activates STAT3. 31402975

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Helminth-derived molecules inhibit colitis-associated colon cancer development through NF-κB and STAT3 regulation. 31407335

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE In addition, reactive oxygen species could induce CD80 expression via the JNK and p38 MAPK pathways, that activated STAT3 transcription factor in colon cancer epithelial cells. 31072360

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE TNM stage and the expression levels of JAK-1 and STAT-3 proteins were independent risk factors influencing the prognosis of colon cancer (P<0.05). 30655751

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 GeneticVariation BEFREE When vemurafenib was applied to two colon cancer cell lines with the BRAF<sup>V600E</sup> mutation, STAT3 was continuously activated after 6 hours. 30320916

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE This therapeutic approach in colon cancer could mediate 5-FU chemoresistance via modulating therapeutic targets (ie, STAT3 and Nrf2 pathways) and decreased 5-FU-related adverse effects. 30993753

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 PosttranslationalModification BEFREE In conclusion, our study suggested that MC-LR promoted the progression of colon carcinoma, at least in part, by regulating the expression miR-221, PTEN and STAT3 phosphorylation, which offers a novel perspective to understand the connection between MC-LR and colon cancer. 30312888

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE JAK2/STAT3 inhibitor AG490 synergistically increases effects of AZD6244 on colon cancer in vitro and in vivo. 30706361

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 GeneticVariation BEFREE Targeting colon cancer with the novel STAT3 inhibitor bruceantinol. 30348989

2019

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE These results suggest that STAT3 and ReB constitute a minimal activator complex for positive regulation of MMP-1 in colon cancer. 30040915

2018

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE In conclusion, p-STAT3 may participate in the progression of the early stage of colon cancer through the up-regulation of CD133, which in turn induces survivin expression. 29432737

2018

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE While STAT3 activation is transient in physiological conditions, STAT3 becomes persistently activated in a high percentage of solid and hematopoietic malignancies (e.g., melanoma, multiple myeloma, breast, prostate, ovarian, and colon cancers), thus contributing to malignant transformation and progression. 29914167

2018

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Moreover, a positive feedback loop between miR-181b and STAT3 that regulated the Warburg effect in colon cancer was also demonstrated. 30054984

2018

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Thus, it was concluded that TPS attenuated the progress of CAC via suppressing IL-6/STAT3 pathway and downstream genes' expressions, which indicated that TPS may be a hopeful antitumor agent for the prevention and treatment of colon cancer. 29656647

2018

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Myc-Associated Zinc Finger Protein Regulates the Proinflammatory Response in Colitis and Colon Cancer via STAT3 Signaling. 30181395

2018

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Our data identify the MDSC-IL-10-STAT3-DNMT3b-IRF8 pathway as a link between chronic inflammation and colon cancer initiation. 30540937

2018

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Thus, the expression of HSP110 in colon cancer contributes to STAT3-dependent tumor growth and the frequent inactivating mutation of this chaperone is probably an important event underlying the improved prognosis in colon cancer displaying MSI. 27819670

2017

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Additionally, p68 positively modulated both mRNA and protein expression levels of Stat3 target genes; promoter activity of Stat3 target gene Mcl-1 in multiple colon cancer cell lines. 27941883

2017

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE Niclosamide inhibition of STAT3 synergizes with erlotinib in human colon cancer. 28367059

2017

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE In our study, we showed that microRNA-1299 (miR-1299) was closely related to the TNM stage of colon cancer, and that the expression of miR-1299 was negatively correlated with the expression of STAT3 in colon cancer which means that miR-1299 can be a negative regulator of STAT3 in colon cancer. 28498395

2017

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE We highlight our recent study on the novel role of STAT3 in Salmonella infection-associated colon cancer. 28223148

2017

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE In current study, we have discovered, using a comprehensive investigative regimen, a novel and tissue-specific role of claudin-3, a tight junction integral protein, in inhibiting colon cancer progression by serving as the common rheostat of Stat-3 and Wnt-signaling activation. 28783170

2017

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE Furthermore, high mRNA expression levels of Stat3 or Jab1 in colon cancer, breast cancer and glioblastoma are associated with significantly shorter survival times from the R2 online database. 27524414

2017

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 Biomarker BEFREE IL-32θ inhibits stemness and epithelial-mesenchymal transition of cancer stem cells via the STAT3 pathway in colon cancer. 26824417

2016

Entrez Id: 6774
Gene Symbol: STAT3
STAT3
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon
0.400 AlteredExpression BEFREE STAT3 is activated in chronically inflamed intestines in human inflammatory bowel diseases and in colitis-associated colon cancer. 27237322

2016