Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.480 GeneticVariation GWASCAT Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer. 30529582

2019
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.480 GeneticVariation GWASCAT Discovery of common and rare genetic risk variants for colorectal cancer. 30510241

2019
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.480 AlteredExpression BEFREE β-Catenin/Tcf7l2-dependent transcriptional regulation of GLUT1 gene expression by Zic family proteins in colon cancer. 31392276

2019
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.480 GeneticVariation GWASCAT GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12. 29471430

2018
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.480 GeneticVariation GWASCAT Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk. 26965516

2016
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.480 GeneticVariation GWASCAT Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk. 24836286

2014
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.480 GeneticVariation BEFREE The present meta-analysis indicated that there were significantly associations between the TCF7L2 rs7903146 polymorphism and risk of breast, prostate and colon cancers, rather than colorectal cancer, lung cancer, and ovarian cancer. 23951231

2013
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.480 Biomarker BEFREE We identified two regions that specifically bind the β-catenin/TCF-4 complex in vitro and in vivo, identifying HMGA1 as an immediate target of the β-catenin/TCF-4 signalling pathway in colon cancer. 22961697

2013
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.480 Biomarker CTD_human T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis. 21383188

2011
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.480 GeneticVariation BEFREE Subjects who were initially cancer-free and carrying certain genetic variants of TCF7L2, most notably the T allele of rs7903146, have an increased risk of colon cancer. 18268068

2008
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.480 GeneticVariation BEFREE These data suggest that colon cancer risk associated with the rs7903146 TCF7L2 polymorphism is modified by use of aspirin/NSAIDs. 18398040

2008
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.480 Biomarker BEFREE Nuclear beta-catenin forms a transcription complex with TCF-4, which is implicated in colon cancer development and progression. 17909039

2007
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.480 Biomarker BEFREE These results delineate a novel role for MSI+TCF4 in leukemia and colon cancer progression. 15905022

2006
Entrez Id: 6934
Gene Symbol: TCF7L2
TCF7L2
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.480 Biomarker BEFREE Recently, the role of TCF-4 has been described in colon cancer and other cancers. 15667799

2005