Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8405
Gene Symbol: SPOP
SPOP
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.330 Biomarker BEFREE Collectively, studies on the Spopd/d mouse support an important role for SPOP in normal uterine function and suggest that this mouse model may prove useful to study the role of SPOP-loss-of-function mutations in the etiopathogenesis of endometrial cancer. 29546395

2018

Entrez Id: 8405
Gene Symbol: SPOP
SPOP
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.330 Biomarker BEFREE Here we analyzed changes in the ubiquitin landscape induced by endometrial cancer-associated SPOP mutations and identified BRD2, BRD3 and BRD4 proteins (BETs) as SPOP-CUL3 substrates that are preferentially degraded by endometrial cancer-associated SPOP mutants. 28805821

2017

Entrez Id: 8405
Gene Symbol: SPOP
SPOP
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.330 GeneticVariation BEFREE However, how SPOP mutations contribute to endometrial cancer remains unknown. 25766326

2015

Entrez Id: 8405
Gene Symbol: SPOP
SPOP
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium
0.330 CausalMutation CGI