Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 Biomarker BEFREE This study suggests that Lp(a)-lowering by 50 mg/dL (105 nmol/L) short-term (ie, 5 years) may reduce CVD by 20% in a secondary prevention setting.High Lp(a) (Lipoprotein[a]) is associated with high risk of incident cardiovascular disease (CVD) in observational studies of individuals without CVD at baseline<sup>1, 2</sup>, that is, in a primary prevention setting. 31578080

2020

Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 Biomarker BEFREE Age (OR: 1.07; 95% CI: 1.03, 1.10), male sex (OR: 1.95; 95% CI: 1.68, 2.23), hypertension (OR: 2.11; 95% CI: 1.64, 2.58), diabetes (OR: 1.95; 95% CI: 1.33, 2.57), body mass index (OR: 1.04; 95% CI: 1.03, 1.05), smoking (OR: 1.71; 95% CI: 1.30, 2.12), elevated lipoprotein(a) (OR: 1.90; 95% CI: 1.10, 2.71), low high-density lipoprotein cholesterol (OR: 1.39; 95% CI: 1.24, 1.53), and a family history of CVD (OR: 1.83, 95% CI: 1.58, 2.07) were found to be significant CVD risk factors in FH. 30527766

2020

Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 GeneticVariation BEFREE Patients with metabolic syndrome (MetS) are at high risk of developing cardiovascular disease (CVD) and lipoprotein(a) (Lp(a)) is an independent risk factor for CVD. 31625055

2020

Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 GeneticVariation BEFREE The association between lipoprotein(a) [Lp(a)] levels and the risk of cardiovascular disease is of great interest but still controversial. 31740238

2020

Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 Biomarker BEFREE Lipoprotein (a) and 10-year Cardiovascular Disease Incidence in Apparently Healthy Individuals: A Sex-based Sensitivity Analysis from ATTICA Cohort Study. 31185726

2019

Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 Biomarker BEFREE Several lipoprotein(a)-lowering therapies are currently being developed with the long-term goal of reducing cardiovascular disease and mortality; however, the relationship between lipoprotein(a) and mortality is unclear. 30608559

2019

Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 Biomarker BEFREE Lipoprotein(a) as a key target in combined therapeutic approaches for cardiovascular disease. 31530423

2019

Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 GeneticVariation BEFREE Elevated low-density lipoprotein cholesterol and/or lipoprotein(a) are established risk factors for cardiovascular disease (CVD). 30799420

2019

Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 GeneticVariation BEFREE Those with evidence of CAD were significantly more likely to be male, inactive, diabetic and with a family history of CVD than participants without CAD.About 20% of patients had lipoprotein(a) (Lp(a)) concentrations above 106.9 nmol/L (fifth quintile). 31481563

2019

Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 GeneticVariation BEFREE It is well-known that Lp(a) levels have an impact on increased risk of CVD which is affected by LPA gene. 31113255

2019

Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 Biomarker BEFREE The causal relationship of lipoprotein(a) with cardiovascular disease has been established. 31577620

2019

Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 Biomarker BEFREE Malondialdehyde, lipoprotein-a, lipoprotein ratios, comprehensive lipid tetrad index and atherogenic index as surrogate markers for cardiovascular disease in patients with psoriasis: a case-control study. 30830310

2019

Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 GeneticVariation BEFREE Lipoprotein (a) [Lp(a)] is an established causal risk factor for cardiovascular disease (CVD), independently of low-density lipoproteins (LDL) and other risk factors. 31493849

2019

Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 Biomarker BEFREE Oxidized phospholipids as a unifying theory for lipoprotein(a) and cardiovascular disease. 30675027

2019

Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 GeneticVariation BEFREE Lipoprotein(a) [Lp(a)] has been considered as a causal risk factor for cardiovascular disease (CVD) in the general population and levels vary in different ethnicities. 31683090

2019

Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 GeneticVariation BEFREE Elevated Lipoprotein(a) (Lp[a]) is a well-known risk factor for cardiovascular disease. 31023762

2019

Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370

2019

Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 AlteredExpression BEFREE The greatest frequency of cardiovascular disease (CVD; 69%) was observed in DM[-]EOCHD[+] patients, whose lipoprotein(a) and insulinemia were also highest (81 nmol/L and 140 pmol/L, respectively). 30105804

2019

Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 Biomarker BEFREE Recently, lipoprotein(a) has emerged as an important cardiovascular risk factor and lipoprotein apheresis has been used to decrease lipoprotein(a) concentrations in patients with marked elevations and cardiovascular disease. 31041550

2019

Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 GeneticVariation BEFREE Elevated serum lipoprotein(a) [Lp(a)] levels are associated with increased cardiovascular disease risk. 31220285

2019

Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 Biomarker BEFREE In pediatric familial hypercholesterolemia, lipoprotein(a) is more predictive than LDL-C for early onset of cardiovascular disease in family members. 30150142

2019

Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 Biomarker BEFREE Clinical trials are under way to lower the lipoprotein (a) (Lp(a)) and its associated oxidized phospholipids, which will provide clinical evidence that targeting inflammation caused by oxidized lipids is a viable approach for CVD. 30946962

2019

Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 Biomarker BEFREE In patients who cannot be treated adequately by drugs it is possible to reduce increased LDL-C and/or lipoprotein(a) (Lp(a)) values by the use of lipoprotein apheresis (LA) with the potential to decrease severe CVD events in the range of 70%->80%. 31818446

2019

Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 Biomarker BEFREE Background Elevated lipoprotein(a) (Lp(a)), a low-density lipoprotein-like particle bound to the polymorphic apolipoprotein(a) (apo(a)), may be causal for cardiovascular disease. 30897995

2019

Entrez Id: 4018
Gene Symbol: LPA
LPA
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.500 GeneticVariation BEFREE Homocysteine and education but not lipoprotein (a) predict estimated 10-year risk of cardiovascular disease in blood donors: a community based cross-sectional study. 31349819

2019