Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 Biomarker BEFREE The CVD group had the lowest activities of PON1. 31626760

2020

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 Biomarker BEFREE AREase, LACase, and CMPAase activities and PON1 concentration were lowest in the CVD group. 31757567

2020

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 AlteredExpression BEFREE In conclusion, in a population-based study of subjects with concurrently high HDL-C and CRP levels, low serum PON1 activity associates with incident CVD risk with risk accentuated at low apoE levels. 31480611

2019

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 GeneticVariation BEFREE In conclusion, our study suggests that sex might chiefly influence PON1 activity and its contribution to cardiovascular disease risk. 31138960

2019

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 Biomarker BEFREE The antioxidant enzyme paraoxonase-1 (PON1) may limit oxidative stress in the development of cardiovascular diseases (CVD) and obstructive sleep apnea (OSA). 30244352

2019

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 Biomarker BEFREE Due to the importance of PON1 in the functionality of high-density lipoprotein (HDL) and its association with CVD, further explorations of its epigenetic regulation using advanced methods such as Methyl-Seq may lead to the identification of new epigenetic contributors that in turn may lead to targeted therapies. 31351988

2019

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 GeneticVariation BEFREE A meta-analysis on relationship between paraoxonase 1 polymorphisms and atherosclerotic cardiovascular diseases. 31302193

2019

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 AlteredExpression BEFREE CVD in RA patients correlate with increased PON1 levels and lower PON1 activity. 30588556

2019

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 Biomarker BEFREE In the past few years, the Paraoxonase multigene family (<i>PON1, PON2, PON3</i>) has been shown to play an important role in pathogenesis of cardiovascular disorders including coronary artery disease (CAD). 31816846

2019

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 Biomarker BEFREE The major aim of this review is to highlight the importance of the role of PON enzymes in the aging process, and in the development of the main diseases present in the elderly: cardiovascular disease, diabetes mellitus, neurodegenerative diseases, and cancer. 31052559

2019

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 Biomarker BEFREE Even though there has been an extensive investigation of the enzyme paraoxonase 1 (PON1) as a biomarker of susceptibility for CVD, there are few reports studying PON1 in MDs. 28441923

2019

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 AlteredExpression BEFREE Low levels of PON1 activity have been observed in association with obesity, a major risk factor for cardiovascular disease (CVD). 31390816

2019

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 Biomarker BEFREE These novel findings highlight potent TAG-lowering properties of exogenous (PJ) and endogenous (PON1) antioxidants in tissues associated with CVD. 30560569

2018

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 AlteredExpression BEFREE Given that the amount and the activity of PON1 in human serum are significantly lower in people suffering from cardiovascular diseases, enhancing both parameters might contribute to their treatment and prevention. 29404699

2018

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 Biomarker BEFREE In this work, we studied the association between the lipid profile and the activity of antioxidant enzymes such as paraoxonase-1 (PON1), superoxide dismutase 1 (SOD1), ceruloplasmin, and catalase, as well as total antioxidant capacity (the ferric-reducing ability of plasma (FRAP)), in 626 volunteers without cardiovascular disease. 30487467

2018

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 Biomarker BEFREE Paraoxonase-1 (PON-1) is a high-density lipoprotein (HDL)-associated enzyme with antioxidative properties, which may protect against the development of cardiovascular disease. 30376039

2018

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 AlteredExpression BEFREE To compare the activity of high-density lipoprotein (HDL)-associated paraoxonase 1 (PON1) in patients with psoriasis (PsO) and patients with psoriatic arthritis (PsA), and to evaluate the association of PON1 activity with the extent of disease activity and severity of the cardiovascular disease (CVD) burden in these patients. 29569857

2018

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 AlteredExpression BEFREE Low paraoxonase (PON)1 activities, and high PON1 and low PON3 protein levels are characteristic of cardiovascular disease. 28544610

2017

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 Biomarker BEFREE Pro-oxidant effects produced by metals can be mitigated by paraoxonase 1 (PON1), an antioxidant enzyme known to prevent cardiovascular disease and atherosclerosis. 28477577

2017

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 Biomarker BEFREE In sum, these findings allowed us to propose serum levels of anti-PON1 and anti-HDL antibodies as potential early biomarkers of endothelial damage and premature atherosclerosis in SLE, thus constituting useful therapeutic targets for the prevention of future CVD in these patients. 29044294

2017

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 Biomarker BEFREE Paraoxonase-1 (PON-1) is an HDL-bound esterase enzyme associated with CVD, but its relationship with incident hypertension has not been previously investigated. 28667918

2017

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 Biomarker BEFREE Myeloperoxidase (MPO) as enzyme which oxidizes lipoproteins and paraoxonase1 (PON1) as anti-oxidative enzyme have been involved in pathogenesis of cardiovascular disease. 30581333

2017

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 AlteredExpression BEFREE Finally, a subset of antioxidant enzymes, the paraoxonases (PON), deserves special attention due to abundant clinical evidence accumulated regarding reduced serum PON1 activity in CKD as a contributor to the increased burden of cardiovascular disease. 29333213

2017

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 AlteredExpression BEFREE Since anti-HDL antibodies have been found to be related to an impaired lipid profile and occurrence of CVD in RA, this study was undertaken to examine the associations between PON-1 activity, anti-HDL antibodies, and CVD according to PON1 genetic variants in patients with RA. 26815637

2016

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.400 Biomarker BEFREE Mice with each PON gene knocked out were generated at UCLA and have been key for elucidating their roles in organophosphorus (OP) metabolism, cardiovascular disease, innate immunity, obesity, and cancer. 27238723

2016