|
HLA-DRB1
|
Malignant tumor of cervix
|
0.100 |
GeneticVariation |
BEFREE |
Protective association of HLA-DRB1*13:02, HLA-DRB1*04:06, and HLA-DQB1*06:04 alleles with cervical cancer in a Korean population.
|
30352277 |
2019 |
|
HLA-DRB1
|
Malignant tumor of cervix
|
0.100 |
Biomarker |
BEFREE |
HLA-B*15 showed a negative association with HPV-16-positive CaCx (0.1, 0.01), whereas DRB1*04 exhibited protection to both HPV-16-positive CaCx and persistent HPV-16 infection (0.3, 0.0001 and 0.1, 0.0002, respectively).
|
31800372 |
2019 |
|
HLA-DRB1
|
Malignant tumor of cervix
|
0.100 |
Biomarker |
BEFREE |
Human Leukocyte Antigen (HLA) Class II -DRB1 and -DQB1 Alleles and the Association with Cervical Cancer in HIV/HPV Co-Infected Women in South Africa.
|
31258717 |
2019 |
|
HLA-DRB1
|
Malignant tumor of cervix
|
0.100 |
GeneticVariation |
BEFREE |
Further, protective associations were evidenced for alleles B*35 and DRB1*10 and haplotypes A*11-B*35 and DRB1*10-DQB1*0501 with cervical cancer in South India.
|
27268619 |
2016 |
|
HLA-DRB1
|
Malignant tumor of cervix
|
0.100 |
GeneticVariation |
BEFREE |
Human leukocyte antigen class II DRB1*1302 allele protects against cervical cancer: At which step of multistage carcinogenesis?
|
26235935 |
2015 |
|
HLA-DRB1
|
Malignant tumor of cervix
|
0.100 |
Biomarker |
BEFREE |
Haplotype analysis highlighted the significant association of HLA- DRB1*07:01-DQB1*02:02 and HLA DRB1*10:01-DQB1*05:01 with cervical cancer, while HLA-DRB1*14:04-DQB1*05:03 and DRB1*15:01-DQB1*06:01 conferred decreased risk for cervical cancer.
|
25673541 |
2014 |
|
HLA-DRB1
|
Malignant tumor of cervix
|
0.100 |
GeneticVariation |
BEFREE |
Our results support the hypothesis that the HLA-DRB1 family alleles and specific alleles might influence the susceptibility or resistance to cervical cancer, suggesting that immune regulation may play a key role in this disease, although further investigations are still needed.
|
24551099 |
2014 |
|
HLA-DRB1
|
Malignant tumor of cervix
|
0.100 |
GeneticVariation |
BEFREE |
Variation in LD between the classic HLA loci, rs9272143 and rs67841474 between populations may explain the different associations of HLA-B*07 and DRB1*1501-DQB1*0602 with cervical cancer between studies.
|
24520070 |
2014 |
|
HLA-DRB1
|
Malignant tumor of cervix
|
0.100 |
GeneticVariation |
BEFREE |
The presence of the HLA-DRB1*13-2 and HLA-DRB1*3(17) alleles was associated with an increased risk of developing cervical cancer.
|
25223804 |
2014 |
|
HLA-DRB1
|
Malignant tumor of cervix
|
0.100 |
Biomarker |
BEFREE |
Our results support the role of HLA-DRB1 and MICA in the pathogenesis of cervical cancer.
|
24403192 |
2014 |
|
HLA-DRB1
|
Malignant tumor of cervix
|
0.100 |
GeneticVariation |
BEFREE |
We also confirmed previously reported associations of B*0702 and DRB1*1501-DQB1*0602 with susceptibility to and DRB1*1301-DQA1*0103-DQB1*0603 with protection against cervical cancer.
|
23482656 |
2013 |
|
HLA-DRB1
|
Malignant tumor of cervix
|
0.100 |
Biomarker |
BEFREE |
HLA-DRB1∗01:01 (OR = 0.12; p = 0.01) may confer protection to the development of CC.
|
21911185 |
2011 |
|
HLA-DRB1
|
Malignant tumor of cervix
|
0.100 |
GeneticVariation |
BEFREE |
Consistent associations across other studies in women with CC and infected by HPV16 were observed for HLA-DRB1*15 (OR, 3.9; 95% CI, 1.6-10.2) and the haplotype DRB1*15 DQB1*0602 (OR, 4.1; 95% CI, 1.4-12.7) compared with control women.
|
19820376 |
2009 |
|
HLA-DRB1
|
Malignant tumor of cervix
|
0.100 |
GeneticVariation |
BEFREE |
The DRB1*13 allele/DRB1*13-DQB1*06 haplotype was strongly protective against risk to HPV infection (p(c) < 0.002) as well as cervical cancer (p(c) 0.01).
|
19272325 |
2009 |
|
HLA-DRB1
|
Malignant tumor of cervix
|
0.100 |
GeneticVariation |
BEFREE |
Association of HLA-DRB1, interleukin-6 and cyclin D1 polymorphisms with cervical cancer in the Swedish population--a candidate gene approach.
|
19585495 |
2009 |
|
HLA-DRB1
|
Malignant tumor of cervix
|
0.100 |
GeneticVariation |
BEFREE |
In a similar fashion, the occurrence of DRB1 *13-DQB1 *06 (OR, 0.17; 95% CI, 0.04-0.80) haplotype was significantly lower in the study patients compared with the controls and may confer a decreased risk of CC among Han race population in the Guangdong Province of China.
|
19027490 |
2008 |
|
HLA-DRB1
|
Malignant tumor of cervix
|
0.100 |
Biomarker |
BEFREE |
These results indicate that HLA-DPB1*1301 may confer susceptibility to cervical cancer, and the haplotypes DRB1*150101-DQB1*0602 and DRB1*070101-DQB1*0201 may contribute to the resistance to the development of cervical cancer among Chinese women.
|
17349874 |
2007 |
|
HLA-DRB1
|
Malignant tumor of cervix
|
0.100 |
GeneticVariation |
BEFREE |
The strongest class II effects are coming from the DQB1 and DRB1 loci, but the DPB1 locus also contributes to the susceptibility to cervical cancer.
|
15238505 |
2004 |
|
HLA-DRB1
|
Malignant tumor of cervix
|
0.100 |
GeneticVariation |
BEFREE |
We have examined the association of variation at the DRB1 and DQB1 loci with HPV16 infection and risk of development of cervical cancer by analysis of 440 cases diagnosed with cervical cancer in situ and 476 age-matched controls in a retrospective case-control study.
|
11519043 |
2001 |
|
HLA-DRB1
|
Malignant tumor of cervix
|
0.100 |
Biomarker |
BEFREE |
In previous studies, the HLA class II haplotype HLA DRB1*0401-DQB1*0301 was shown to correlate with susceptibility to HPV infection, CIN and cervical cancer while DRB1*0101-DQB1*0501 indicated protection.
|
11562779 |
2001 |
|
HLA-DRB1
|
Malignant tumor of cervix
|
0.100 |
Biomarker |
BEFREE |
Observations from this study confirm earlier findings of a negative association between DRB1*13 and cervical cancer and suggest that specific DRB1-DQB1 haplotype combinations, rather than individual DQB1*03 alleles, increase the risk for cervical cancer.
|
11588129 |
2001 |
|
HLA-DRB1
|
Malignant tumor of cervix
|
0.100 |
Biomarker |
BEFREE |
DQB1*0301 alone (2P = 0.02) and in combination with DRB1*0401 (2P = 0.02) was found to be associated with cervical cancer.
|
10755413 |
2000 |
|
HLA-DRB1
|
Malignant tumor of cervix
|
0.100 |
GeneticVariation |
BEFREE |
The frequency of HLA-DRB1 and -DQB1 alleles in cervical cancer cases in the Czech Republic.
|
10732716 |
1999 |