Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.100 AlteredExpression BEFREE A total of 60 biopsy samples (40 normal and 20 ADCs of CC) were analyzed for the expression of Cyclin D1 in HPV associated ADCs via immunohistochemistry and by immunoblotting. 30903019

2019

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.100 AlteredExpression BEFREE Expression Of Cyclin D1 Protein Isoforms And Its Prognostic Significance In Cervical Cancer. 31695498

2019

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.100 GeneticVariation BEFREE However, in case of cervical cancer risk a non-significant association was reported under the recessive model (GG+GA vs AA: OR = 1.52, 95%CI = 0.60-3.90, <i>P</i>=0.38) with reference to <i>CCND1</i> polymorphism (rs9344). 30361291

2018

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.100 AlteredExpression BEFREE The CC cells were transfected with siRNA or si-NC against ANRIL to find out whether ANRIL can influence the expression of Cyclin D1, CDK4, CDK6, E-cadherin, vimentin and N-cadherin, as well as affect cell proliferation, cell apoptosis, cell migration and cell invasion of CC cells. 30198868

2018

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.100 AlteredExpression BEFREE In general, this article disclosed that NEAT1 could facilitate the radio-resistance of cervical cancer via competitively binding miR-193b-3p to up-regulate the expression of cyclin D1. 29416780

2018

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.100 AlteredExpression BEFREE OVCA1 expression and its correlation with the expression levels of cyclin D1 and p16 in cervical cancer and intraepithelial neoplasia. 28521400

2017

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.100 AlteredExpression BEFREE In this work, we found that the expression of miR-202 is obviously decreased in both CC cell lines and tissues, and negatively related with the expression of cyclin D1 in SiHa, HeLa and Caski cells. 27732565

2016

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.100 Biomarker BEFREE Thus, we identified a new pathway employing miR-2861, EGFR, AKT2, and CCND1 that may mediate HPV16 E6 induced initiation and progression of cervical cancer. 27364926

2016

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.100 Biomarker BEFREE We further investigated the molecular mechanisms of miR-195 and cyclin D1 in CC cell lines HeLa and SiHa. 26631043

2016

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.100 GeneticVariation BEFREE In summary, the present meta-analysis provides evidence that genotypes for the cyclin D1 (CCND1) G870A polymorphism may be not associated with genetic susceptibility of cervical cancer. 24737585

2014

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.100 GeneticVariation BEFREE Our meta-analysis indicated that CCND1 G870A might be not the crucial risk factor for the development of cervical cancer. 25204741

2014

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.100 GeneticVariation BEFREE CCND1 rs9344 polymorphisms are associated with the genetic susceptibility to cervical cancer in Chinese population. 21594903

2012

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.100 AlteredExpression BEFREE Explore the role of plasminogen activator inhibitor-1 (PAI-1) in cervical cancer and its relationship to hypoxia and the expression of p53, Ku70/80, and cyclin D1. 23111469

2012

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.100 GeneticVariation BEFREE The G870A polymorphism in CCND1 may not contribute to the etiology of cervical cancer in Chinese populations. 20473525

2011

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.100 GeneticVariation BEFREE We examined the distribution of the CCND1 A870G (rs9344) polymorphic variant in patients with cervical cancer (n = 129) and healthy individuals (n = 288) in a sample of a Polish cohort. 20680537

2011

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.100 GeneticVariation BEFREE A significant association of CxCa with various polymorphisms was observed: rs1800797 in the IL-6 gene (odds ratio [OR] = 0.88, 95% confidence intervals [CI]: 0.79-0.99); rs1041981 in the LTA gene (OR = 0.87, 95% CI: 0.78-0.98), and rs9344 in the CCND1 gene (OR = 1.14, 95% CI: 1.02-1.27), for those individuals carrying the rare allele. 19585495

2009

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.100 GeneticVariation BEFREE Our data suggest that CCND1 G870A polymorphism could act as a risk factor for the development of cervical cancer. 19489683

2009

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.100 AlteredExpression BEFREE It is suggested that Pin1 may contribute to cervical tumorigenesis by regulating cyclin D1 expression and Pin1 may serve as a promising molecular target for diagnostics and therapeutics in cervical cancer. 16865248

2006

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.100 GeneticVariation BEFREE The proportion of cervical cancer cases attributable to the GG CCND1 genotype was 17.26%. 15949570

2005

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.100 GeneticVariation BEFREE Thus, we undertook this study to investigate the association between CCND1 polymorphisms and susceptibility to cervical cancer in Korean women. 15896460

2005

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.100 Biomarker BEFREE Many of the heterogeneous regions contained genes known to influence the prognosis of cervical cancer, such as 7p (EGFR), 8q (c-MYC), 11qcen-q13 (CCND1) and 17q (ERBB2). 15221962

2004

Entrez Id: 595
Gene Symbol: CCND1
CCND1
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.100 AlteredExpression BEFREE Underexpression of cyclin D1 was regulated at the level of transcription in cervical cancer. 11371120

2001