Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE CP-31398, a styrylquinazoline, emerges from a screen for therapeutic agents that restore the wild-type DNA-binding conformation of mutant p53 to suppress tumors in vivo, but its effects on cervical cancer (CC) remain unknown. 30132866

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 AlteredExpression BEFREE The expression of p53 was negative in normal cervix, while there were 48 p53-positive cases (61.54%) and 30 p53-negative cases (38.46%) in patients with cervical cancer (p<0.05). 30003750

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE Furthermore, we found that transcription factor TP53 could promote the expression of miR-3647-5p, suggesting that the dysfunction of miR-3647-5p in cervical cancer may be related to TP53. 31436390

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE In this report, we aimed to explore the roles of gene polymorphisms affecting x-ray repair cross complementing 1 (XRCC1), the tumor protein p53 (TP53), and fibroblast growth factor receptor 3 (FGFR3) in the context of susceptibility to cervical cancer. 30616520

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE Taken together, the results of this study showed that TIPE1 serves as an oncogene by restricting p53 activity in the development of cervical cancer, suggesting that TIPE1 will provide a new potential target for cervical cancer therapy and can be used as a biomarker to predict patient prognosis. 30445600

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 AlteredExpression BEFREE In the cervical cancer cell (HeLa) with endogenous high TRIM3 expression, increased expression of miR-454-3p obviously inhibited TRIM3 expression and then manipulating cell growth and apoptosis, down-regulating the expression of P53 and cleaved caspase-3 via P38 MAPK signaling. 31270028

2019

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE HPV16 abrogation of p53 binding to the IRF6 promoter was shown by ChIP in tissues from patients with cervical cancer. 30089163

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 AlteredExpression BEFREE Loss of miR-140/142/340/383 contributes to PD-L1 upregulation. miR-18a enhances PD-L1 levels by targeting PTEN, WNK2 (ERK1/2 pathway inhibitor), and SOX6 (Wnt/β-catenin pathway inhibitor and p53 pathway activator) to activate the PI3K/AKT, MEK/ERK, and Wnt/β-catenin pathways and inhibit the p53 pathway, and miR-18a also directly suppresses the expression of the tumor suppressors BTG3 and RBSP3 (CTDSPL). miR-18a overexpression in CC cells is triggered by OCT4 overexpression. 29855617

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE Therefore, blocking E6-mediated p53 degradation might be an alternative treatment for cervical cancer. 29274324

2018

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 AlteredExpression BEFREE This study evaluated the immunohistochemical (IHC) expression of p16, p53 and Ki-67 in precancerous lesions and in cervical cancer (CC). 28554769

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE Radiotherapy modulates expression of EGFR, ERCC1 and p53 in cervical cancer. 29160417

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE These results suggest that RACK1 promotes cell growth and invasion and inhibits the senescence and apoptosis in cervical cancer cells probably by affecting the p53 pathway. 29048616

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE Further, we explored p53 and human epidermal growth factor receptor 2 as potential prognostic markers in cervical cancer. 28599900

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE Oncogenic protein E6 of human papillomavirus type 16 (HPV-16) is believed to involve in the aberrant methylation in cervical cancer as it upregulates DNA methyltransferase 1 (DNMT1) through tumor suppressor p53. 28077801

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 AlteredExpression BEFREE These results suggest that MSI-2 plays a crucial role in promoting the aggressive phenotypes of CC cells, and restoration of miR-143/miR-107 by Mithramycin A via activation of p53 may represent a novel therapeutic approach for CC. 29073938

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE Furthermore, ADCentropy was identified as a potential imaging biomarker for tumor heterogeneity and might be able to indicate further molecular changes like loss of p53 expression, which is associated with EMT and consequentially indicates a poor prognosis in CC. 28315203

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE The combination of relative low HPV infection and variant TP53 72C allele overtransmission provide a plausible explanation for the low incidence of cervical cancer in our population. 28393355

2017

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE The Arg>Pro polymorphism in codon 72 of p53 gene is known to affect the susceptibility of cervical cancer differently in different population worldwide although information regarding its role in determining survival status and disease outcome in patients is lacking. 28139534

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE The purpose of this study was to analyze the association of 29 candidate single nucleotide polymorphisms (SNPs) in genes in the DNA repair pathway, TP53, and TP53BP1 with the risk of cervical cancer. 26130668

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE Thus, these findings suggested that uc.206 acts as a novel oncogene by targeting the P53 gene and promoting CC cell growth, which might be beneficial for cervical cancer therapy. 26925787

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE These findings suggest that the pri-miR-34b/c rs4938723 and TP53 Arg72Pro polymorphisms may contribute to the genesis of cervical cancer. 26619844

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE Derepression of wild-type p53 by suppressing its negative inhibitor iASPP (Inhibitor of apoptosis-stimulating protein of p53) represents a potential therapeutic option for cervical cancer (CC). 27765948

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 Biomarker BEFREE Interestingly, we found a very high mutation rate of TP53 in a cancer type where p53 is initially inactivated via E6 during the development of cervical cancer. 27272838

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 GeneticVariation BEFREE This study aims to investigate whether the genotype distribution of p53 codon 72 may be a risk factor for cervical cancer among Gabonese women. 25502079

2015

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix
0.400 AlteredExpression BEFREE The combined determination of Ebp1 and p53 expression levels in cervical cancer patients could support the effective prediction of metastatic potential and patient prognosis. 26436510

2015